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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Principal Investigators Ellen Leibenluft, M.D.   Dr. Leibenluft received her B.A. from Yale University and her M.D. from Stanford University. After completing residency training at Georgetown University Hospital, she served on the faculty there as director of the psychiatric inpatient unit and day hospital. She came to the NIMH in 1989, and since that time has been conducting research on bipolar disorder. In addition to that work, Dr. Leibenluft has written and spoken widely on gender differences in the prevalence and symptomatology of mood disorders. Her awards include the Distinguished Psychiatrist Award of the American Psychiatric Association and a Visiting Professorship at the Department of Psychiatry, Cornell University School of Medicine. Research Interests Dr. Leibenluft is Chief of the Section on Bipolar Spectrum Disorders in the Emotion and Development Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health. Her main area of research interest is bipolar disorder in children and adolescents, with a particular emphasis on differences between children and adults in the presentation of the illness; neural mechanisms underlying the symptoms of the illness; and the development of new treatment strategies for early-onset bipolar disorder. She has also studied rapid cycling bipolar disorder (a severe form of the illness) in adults and the role of the sleep-wake cycle in bipolar disorder. Representative Selected Recent Publications: Ellen Leibenluft, M.D., Brendan A. Rich, Ph.D., Deborah T. Vinton, B.A., Eric E. Nelson, Ph.D., Stephen J. Fromm, Ph.D., Lisa H. Berghorst, B.S., Paramjit Joshi, M.D., Adelaide Robb, M.D., Russell J. Schachar, M.D., Daniel P. Dickstein, M.D., Erin B. McClure, Ph.D., Daniel S. Pine, M.D.: Neural Circuitry Engaged During Unsuccessful Motor Inhibition in Pediatric Bipolar Disorder. American Journal of Psychiatry, 164:52–60, 2007. (View PDF) Brendan A. Rich, Ph.D., Mariana Schmajuk, B.S., Koraly E. Perez-Edgar, Ph.D., Nathan A. Fox, Ph.D., Daniel S. Pine, M.D., Ellen Leibenluft, M.D.: Different Psychophysiological and Behavioral Responses Elicited by Frustration in Pediatric Bipolar Disorder and Severe Mood Dysregulation American Journal of Psychiatry, 164:309�317), 2007. (View PDF) Brendan A. Rich, Deborah T. Vinton, Roxann Roberson-Nay, Rebecca E. Hommer, Lisa H. Berghorst, Erin B. McClure, Stephen J. Fromm, Daniel S. Pine, and Ellen Leibenluft: Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder PNAS, vol. 103, no. 23, 8900�8905 2006. (View PDF) Melissa A. Brotman, Mariana Schmajuk, Brendan A. Rich, Daniel P. Dickstein, Amanda E. Guyer, E. Jane Costello, Helen L. Egger, Adrian Angold, Daniel S. Pine, and Ellen Leibenluft: Prevalence, Clinical Correlates, and Longitudinal Course of Severe Mood Dysregulation in Children Biol. Psychiatry, 60:991�997, 2006. (View PDF) McClure EB, Treland JE, Snow J, Schmajuk M, Dickstein DP, Towbin KE, Charney DS, Pine DS, Leibenluft E: Deficits in social cognition and response flexibility in pediatric bipolar disorder. American Journal of Psychiatry, 162: 1644-1651, 2005. (View PDF) Leibenluft E, Charney DS, Towbin KE, Bhangoo RK, Pine DS: Defining clinical phenotypes of juvenile mania. American Journal of Psychiatry, 160: 430-437, 2003. (View PDF) Address:   Phone: 301-496-9435 Email Dr. Leibenluft FAX   Lab Web Site: http://intramural.nimh.nih.gov/mood/     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.