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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Principal Investigators Joel E. Kleinman, M.D., Ph.D.   Joel E. Kleinman, M.D., Ph.D. is the Section Chief of the Section on Neuropathology and the Deputy Chief of the Clinical Brain Disorders Branch. Dr. Kleinman received his B.S., M.D. and Ph.D. from the University of Chicago. He completed an internship at San Francisco General Hospital (University of California Medical School in San Francisco) and residencies in psychiatry and neurology at Massachusetts Mental Health Center (Harvard Medical School) and George Washington University Medical School, respectively. He has been at the NIMH since 1976. Research Interests The research program of the Section on Neuropathology is primarily interested in the neuropathology of schizophrenia and seeks to determine the molecular, cellular and genetic mechanisms that underlie this syndrome. The section investigates these mechanisms by focusing on neural circuits that are believed to underlie schizophrenia, including the prefrontal cortex, medial temporal lobe, brainstem and striatum with special influence on molecules involved in synapse formation, plasticity and neurodevelopment. The section also investigates susceptibility genes for schizophrenia and their relationships to these neural circuits. Representative Selected Recent Publications: Weickert CS, Miranda-Angulo AL, Wong J, Perlman WR, Ward SE, Vakkalanka R, Straub RE, Weinberger D R and Kleinman JE: Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia. Human Molecular Genetics. 17:2293-2309, 2008. Law AJ, Kleinman JE, Weinberger DR and Weickert CS: Disease associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice variant expression in the brain in schizophrenia. Human Molecular Genetics, 16:129-141, 2007. Lipska BK, Peters T, Hyde TM, Halim N, Horowitz C, Mitkus S, Weickert CS, Matsumoto M, Sawa A, Straub R, Vakkalanka R, Herman MM, Weinberger DR and Kleinman JE: Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Human Molecular Genetics, 15:1245-1258, 2006. Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, Herman MM, Weinberger DR and Kleinman JE: Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Archives of General Psychiatry, 61:544-555, 2004. Akil M, Kolachana BS, Rothmond DA, Hyde TM, Weinberger DR and Kleinman JE : COMT genotype and dopamine regulation in the human brain. J. of Neuroscience, 23:2008-2013, 2003. Address:   Phone: 301-402-7908 Email Dr. Kleinman Fax:   Lab Web Site: http://cbdb.nimh.nih.gov/     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.