| | Staff Scientists and Clinicians
| Brian M. Martin, Ph.D. |
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Dr.
Martin is chief of the Unit
on Molecular Structure, Laboratory of Neurotoxicology.
He attended the University of Waterloo, Canada where he
obtained a BSc in applied chemistry and a PhD in Chemistry.
He did post doctoral training at the Carlsberg Laboratory,
Copenhagen Denmark and the Max Planck Institute in Dortmund,
Germany. He has a strong background in protein chemistry,
has been on the editorial board of two journals and has
served on the NIMH technology Assessment Committee. He
came to the Institute from NINDS in 1986 as a member of
the Clinical Neuroscience Branch. |
| Research Interests |
| During the past decade the human genome has been mostly decoded. However, given the discovery of many genes and their annotation in databases, we still don't know their distribution or the function of the proteins that they encode. Furthermore, we don't understand the translational consequences of these genes nor the post-translational events that result in proteins found in different tissues, organs or biological fluids. The study of the protein component of an organism, proteomics, includes the study of protein expression changes during development or in differentiation processes in either the normal or disease state as well as protein-protein interaction. Dr. Martin studies the structure function relations of proteins/ peptides as well as the subsequent cloning and expression of cDNAs for proteins/ peptides of interest. The Unit focuses on the identification and characterization of bioactive components of biological fluids and tissues. Other projects of interest are drawn from proteins that are of medical interest due to their ability to interact with binding partners, their allergic properties or their resulting modification/ alteration by compounds normally prescribed in a medical setting or their propensity to cause or alter disease states. The group makes use of mass spectral techniques such as SELDI, MALDI and MS/MS to study, define and interpret the changes in protein expression and structure in biological systems. |
| Representative Selected Recent Publications: |
- Orvisky E, Drake SK, Martin BM, Abdel-Hamid M, Ressom HW, Varghese RS, An Y, Saha D, Hortin GL, Loffredo CA, Goldman R:
Enrichment of low molecular weight fraction of serum for MS analysis of peptides associated with hepatocellular carcinoma.
Proteomics, 6(9): 2895-2902, 2006. (View PDF)
- Fujigaki H, Saito K, Lin F, Fujigaki S, Takahashi K, Martin BM, Chen CY, Masuda J, Kowalak J, Takikawa O, Seishima M, Markey SP:
Nitration and inactivation of IDO by peroxynitrite.
Journal of Immunology, 176(1): 372-379, 2006. (View PDF)
- Rossi L, Martin BM, Hortin GL, White RL, Foster M, Moharram R, Stroncek D, Wang E, Marincola FM, Panelli MC:
Inflammatory protein profile during systemic high dose interleukin-2 administration.
Proteomics, 6(2): 709-720, 2006. (View PDF)
- Martin BM, Karczewska E, Pliszka B:
Effect of nucleotide on interaction of the 567-578 segment of myosin heavy chain with actin.
Biochim Biophys Acta., 1764(2): 217-222, 2006. (View PDF)
- LaMarca ME, Goldstein M, Tayebi N, Arcos-Burgos M, Martin BM, Sidransky E:
A novel alteration in metaxin 1, F202L, is associated with N370S in Gaucher disease.
Journal of Human Genetics, 49(4): 220-222. Epub 2004 Mar 13. (View PDF)
- Caputo E, Moharram R, Martin BM:
Methods for on-chip protein analysis. Analytical Biochemistry, 321(1): 116-124, 2003. (View PDF)
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