Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health www.cancer.gov
CCR - For Our Staff| Home |

Our Science – Barchi Website

Joseph J. Barchi Jr., Ph.D.

Selected Publications
1)  Kaczmarek P, Keay SK, Tocci GM, Koch KR, Zhang CO, Barchi JJ, Grkovic D, Guo L, Michejda CJ.
Structure-Activity Relationship Studies for the Peptide Portion of the Bladder Epithelial Cell Antiproliferative Factor from Interstitial Cystitis Patients.
J. Med. Chem. 2008. [Journal]
2)  Marquez VE, Sun G, Siddiqui MA, Lee YC, Barchi JJ, Filippov IV, Landsman NA, Kelley JA.
What are the consequences of freezing the anomeric effect in nucleosides?.
Nucleic Acids Symp Ser (Oxf). 543-4, 2008. [Journal]
3)  Barchi JJ, Karki RG, Nicklaus MC, Siddiqui MA, George C, Mikhailopulo IA, Marquez VE.
Comprehensive structural studies of 2',3'-difluorinated nucleosides: comparison of theory, solution, and solid state.
J. Am. Chem. Soc. 130: 9048-57, 2008. [Journal]
4)  Garg H, Francella N, Tony KA, Augustine LA, Barchi JJ, Fantini J, Puri A, Mootoo DR, Blumenthal R.
Glycoside analogs of beta-galactosylceramide, a novel class of small molecule antiviral agents that inhibit HIV-1 entry.
Antiviral Res. 2008. [Journal]
5)  Valdez CA, Saavedra JE, Showalter BM, Davies KM, Wilde TC, Citro ML, Barchi JJ, Deschamps JR, Parrish D, El-Gayar S, Schleicher U, Bogdan C, Keefer LK.
Hydrolytic Reactivity Trends among Potential Prodrugs of the O(2)-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial Activity.
J. Med. Chem. 2008. [Journal]
6)  Sundgren A, Barchi JJ.
Varied presentation of the Thomsen-Friedenreich disaccharide tumor-associated carbohydrate antigen on gold nanoparticles.
Carbohydr. Res. 343: 1594-604, 2008. [Journal]
7)  Maderia M, Shenoy S, Van QN, Marquez VE, Barchi JJ.
Biophysical studies of DNA modified with conformationally constrained nucleotides: comparison of 2'-exo (north) and 3'-exo (south) 'locked' templates.
Nucleic Acids Res. 35: 1978-91, 2007. [Journal]
8)  Svarovsky S, Barchi Jr JJ.
De Novo Synthesis of Biofunctional Carbohydrate-Encapsulated Quantum Dots.
ACS Symposium Series: Frontiers in Modern Carbohydrate Chemisrtry. 5.2, 2007. Full Text Article. [Journal]
9)  Furrer J, Luy B, Basrur V, Roberts DD, Barchi JJ.
Conformational analysis of an alpha3beta1 integrin-binding peptide from thrombospondin-1: implications for antiangiogenic drug design.
J. Med. Chem. 49: 6324-33, 2006. [Journal]
10)  Furrer J, Luy B, Basrur V, Roberts DD, Barchi Jr JJ.
Conformational analysis of an alpha3beta1 integrin-binding peptide from thrombospondin-1: implications for antiangiogenic drug design.
J Med Chem. 49: 6324-33, 2006. Full Text Article. [Journal]
11)  Deng J, Kelley JA, Barchi JJ, Sanchez T, Dayam R, Pommier Y, Neamati N.
Mining the NCI antiviral compounds for HIV-1 integrase inhibitors.
Bioorg Med Chem. 14: 3785-92, 2006. [Journal]
12)  Cysyk RL, Parker RJ, Barchi JJ, Steeg PS, Hartman NR, Strong JM.
Reaction of Geldanamycin and C17-Substituted Analogues with Glutathione: Product Identifications and Pharmacological Implications.
Chem Res Toxicol. 19: 376-381, 2006. [Journal]
13)  Oishi S, Shi ZD, Karki RG, Worthy KM, Bindu L, Chertov O, Esposito D, Frank P, Gillette WK, Maderia M, Barchi Jr JJ, Nicklaus MC, Hartley J, Fisher RJ, Burke Jr TR. Shimohigashi Y, eds.
Application of beta-branched allylglycine equivalents to macrocyclic Grb2 SH2 domain-binding inhibitors. In: Peptide Science 2004. Volume .
Osaka: The Japanese Peptide Society; 2005. p. 123-126 [Book Chapter]
14)  Liu F, Oishi S, Karki R, Shi Z, Worthy KM, Bindu LK, Maderia M, Nicklaus M, Barchi Jr JJ, Fisher RJ, Burke Jr TR. Blondelle SE, eds.
High affinity Grb2 SH2 domain-binding macrocycles derived from ring-closing methathesis of alkenylglycine residues with beta-vinyl phosphotyrosyl mimetics. In: Understanding Biology Using Peptides. Volume .
La Costa, CA: American Peptide Society; 2005. p. 559-560 [Book Chapter]
15)  Wu Z, Maderia M, Barchi JJ, Marquez VE, Bax A.
Changes in DNA bending induced by restricting nucleotide ring pucker studied by weak alignment NMR spectroscopy.
Proc Natl Acad Sci U S A. 102: 24-8, 2005. [Journal]
16)  Showalter BM, Reynolds MM, Valdez CA, Saavedra JE, Davies KM, Klose JR, Chmurny GN, Citro ML, Barchi JJ, Merz SI, Meyerhoff ME, Keefer LK.
Diazeniumdiolate ions as leaving groups in anomeric displacement reactions: A protection-deprotection strategy for ionic diazeniumdiolates.
J Am Chem Soc. 127: 14188-89, 2005. [Journal]
17)  Maderia M, Wu J, Bax A, Shenoy S, O'Keefe B, Marquez VE, Barchi JJ.
Engineering DNA topology with locked nucleosides: a structural study.
Nucleosides Nucleotides Nucleic Acids. 24: 687-90, 2005. [Journal]
18)  Oishi S, Karki RG, Shi ZD, Worthy KM, Bindu L, Chertov O, Esposito D, Frank P, Gillette WK, Maderia M, Hartley J, Nicklaus MC, Barchi JJ, Fisher RJ, Burke TR.
Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic.
Bioorg Med Chem. 13: 2431-8, 2005. [Journal]
19)  Svarovsky SA, Szekely Z, Barchi Jr JJ.
Synthesis of gold nanoparticles bearing the Thomsen-Friedenreich disaccharide: a new multivalent presentation of an important tumor antigen.
Tetrahedron: Asymmetry. 16: 587-598, 2005. [Journal]
20)  Marquez VE, Barchi JJ, Kelley JA, Rao KV, Agbaria R, Ben-Kasus T, Cheng JC, Yoo CB, Jones PA.
Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology.
Nucleosides Nucleotides Nucleic Acids. 24: 305-18, 2005. [Journal]
21)  Keay SK, Szekely Z, Conrads TP, Veenstra TD, Barchi JJ, Zhang CO, Koch KR, Michejda CJ.
An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide.
Proc Natl Acad Sci U S A. 101: 11803-8, 2004. [Journal]
22)  Keay S, Szekely Z, Conrads TP, Veenstra TD, Barchi JJ, Zhang CO, Koch K, Michejda CJ.
Complete characterization of an antiproliferative factor from bladder epithelial cells of interstitial cystitis patients.
J Urology. 171: 94, 2004. [Journal]
23)  Marquez VE, Ben-Kasus T, Barchi JJ, Green KM, Nicklaus MC, Agbaria R.
Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker.
J Am Chem Soc. 126: 543-9, 2004. [Journal]
24)  Svarovsky SA, Taraban MB, Barchi Jr JJ.
Facile photochemical synthesis of mixed siloxyacetal glycosides as potential pH-sensitized prodrugs for selective treatment of solid tumors.
Org Biomol Chem. 2: 3155-61, 2004. [Journal]
25)  Maier MA, Choi Y, Gaus H, Barchi JJ, Marquez VE, Manoharan M.
Synthesis and characterization of oligonucleotides containing conformationally constrained bicyclo[3.1.0]hexane pseudosugar analogs.
Nucleic Acids Res. 32: 3642-50, 2004. [Journal]
26)  Choi Y, George C, Comin MJ, Barchi JJ, Kim HS, Jacobson KA, Balzarini J, Mitsuya H, Boyer PL, Hughes SH, Marquez VE.
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.
J Med Chem. 46: 3292-9, 2003. [Journal]
27)  Svarovsky SA, Barchi JJ.
Highly efficient preparation of tumor antigen-containing glycopeptide building blocks from novel pentenyl glycosides.
Carbohydr Res. 338: 1925-35, 2003. [Journal]
28)  Nacro K, Lee J, Lewin NE, Blumberg PM, Marquez VE.
Conformationally Constrained Analogues of Diacylglycerol (DAG). 19. Asymmetric Syntheses of (3R)- and 3(S)-3-Hydroxy-4,4-disubstituted Heptonon-1,4-lactones as Protein Kinase C (PK-C) Ligands with Increased Hydrophilicity.
Tetrahedron. 58: 5335-5345, 2002. [Journal]
29)  Neamati N, Barchi JJ.
New paradigms in drug design and discovery.
Curr Top Med Chem. 2: 211-27, 2002. [Journal]
30)  Luy B, Barchi JJ, Marino JP.
S(3)E-E.COSY methods for the measurement of (19)F associated scalar and dipolar coupling constants.
J Magn Reson. 152: 179-84, 2001. [Journal]
31)  Ford H, Dai F, Mu L, Siddiqui MA, Nicklaus MC, Anderson L, Marquez VE, Barchi JJ.
Adenosine deaminase prefers a distinct sugar ring conformation for binding and catalysis: kinetic and structural studies.
Biochemistry. 39: 2581-92, 2000. [Journal]
32)  Barchi JJ.
Emerging roles of carbohydrates and glycomimetics in anticancer drug design.
Curr Pharm Des. 6: 485-501, 2000. [Journal]
33)  Chen IJ, Neamati N, Nicklaus MC, Orr A, Anderson L, Barchi JJ, Kelley JA, Pommier Y, MacKerell AD.
Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets.
Bioorg Med Chem. 8: 2385-98, 2000. [Journal]
34)  Mu L, Sarafianos SG, Nicklaus MC, Russ P, Siddiqui MA, Ford H, Mitsuya H, Le R, Kodama E, Meier C, Knispel T, Anderson L, Barchi JJ, Marquez VE.
Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase.
Biochemistry. 39: 11205-15, 2000. [Journal]
35)  Barchi JJ, Huang XL, Appella DH, Christianson LA, Gellman SH.
Solution Conformations of Helix-Forming Beta-Amino Acid Homooligomers.
J Am Chem Soc. 122: 2711-2718, 2000. [Journal]
36)  Siddiqui MA, Driscoll JS, Abushanab E, Kelley JA, Barchi JJ, Marquez VE.
The.
Nucleosides Nucleotides Nucleic Acids. 19: 1-12, 2000. [Journal]
37)  Appella DH, Barchi JJ, Gellman SH.
Formation of Short, Stable Helices in Aqueous Solution by Beta-Amino Acid Hexamers.
J Am Chem Soc. 121: 2309-2310, 1999. [Journal]
38)  Sharma P, Steinbach PJ, Sharma M, Amin ND, Barchi JJ, Pant HC.
Identification of substrate binding site of cyclin-dependent kinase 5.
J Biol Chem. 274: 9600-6, 1999. [Journal]
39)  Chu RA, Takei J, Barchi JJ, Bai Y.
Relationship between the native-state hydrogen exchange and the folding pathways of barnase.
Biochemistry. 38: 14119-24, 1999. [Journal]
40)  Marquez VE, Ezzitouni A, Russ P, Siddiqui MA, Ford H, Feldman RJ, Mitsuya H, George C, Barchi JJ.
HIV-1 Reverse Transcriptase Can Discriminate Between Two Conformationally Locked Carbocyclic AZT Triphosphate Analogues.
J Am Chem Soc. 120: 2780-879, 1998. [Journal]
41)  Marquez VE, Ezzitouni A, Russ P, Siddiqui MA, Ford H, Feldman RJ, Mitsuya H, George C, Barchi JJ.
Lessons from the Pseudorotational Cycle: Conformationally Rigid AZT Carbocyclic Nucleosides and their Interaction with Reverse Transcriptase.
Nucleosides & Nucleotides. 17: 1881-1884, 1998. [Journal]
42)  Sharma P, Barchi JJ, Huang X, Amin ND, Jaffe H, Pant HC.
Site-specific phosphorylation of Lys-Ser-Pro repeat peptides from neurofilament H by cyclin-dependent kinase 5: structural basis for substrate recognition.
Biochemistry. 37: 4759-66, 1998. [Journal]
43)  Ikeda H, Fernandez R, Wilk A, Barchi JJ, Huang X, Marquez VE.
The effect of two antipodal fluorine-induced sugar puckers on the conformation and stability of the Dickerson-Drew dodecamer duplex [d(CGCGAATTCGCG)]2.
Nucleic Acids Res. 26: 2237-44, 1998. [Journal]
44)  Barchi JJ, Jeong LS, Siddiqui MA, Marquez VE.
Conformational analysis of the complete series of 2' and 3' monofluorinated dideoxyuridines.
J Biochem Biophys Methods. 34: 11-29, 1997. [Journal]
45)  Huang X, Barchi JJ, Lung FD, Roller PP, Nara PL, Muschik J, Garrity RR.
Glycosylation affects both the three-dimensional structure and antibody binding properties of the HIV-1IIIB GP120 peptide RP135.
Biochemistry. 36: 10846-56, 1997. [Journal]
46)  Sharma P, Barchi JJ, Huang X, Amin ND, Albers RW, Perlstein R, Pant HC.
Phosphorylation of Neurofilament Proteins by Neuronal Cyclin Dependent Kinase-5: Structural Basis.
FASEB Journal. 11: 1913-, 1997. [Journal]
47)  Appella DH, Christianson LA, Klein DA, Powell DR, Huang X, Barchi JJ, Gellman SH.
Residue-based control of helix shape in beta-peptide oligomers.
Nature. 387: 381-4, 1997. [Journal]
48)  Buolamwini JK, Barchi JJ.
Solution NMR Conformational Analysis of the Potent Equilibrative Sensitive (ES) Nucleoside Transporter Inhibitor, S-(4-Nitrobenzyl)mercaptopurine Riboside (NBMPR).
Nucleosides & Nucleotides. 16: 2101-2110, 1997. [Journal]
49)  Sharma P, Barchi JJ, Huang X, Amin ND, Jaffe H, Pant HC.
Structural Basis of Neurofilament Phosphorylation by Cyclin Dependent Kinase-5.
Biophysical Journal. 72: TH262-TH262, 1997. [Journal]
50)  Barchi JJ, Nomizu M, Otaka A, Roller PP, Burke TR.
Conformational analysis of cyclic hexapeptides designed as constrained ligands for the SH2 domain of the p85 subunit of phosphatidylinositol-3-OH kinase.
Biopolymers. 38: 191-208, 1996. [Journal]
51)  Huang X, Smith MC, Berzofsky JA, Barchi JJ.
Structural comparison of a 15 residue peptide from the V3 loop of HIV-1IIIb and an O-glycosylated analogue.
FEBS Lett. 393: 280-6, 1996. [Journal]
52)  Barchi JJ, Cooney DA, Ahluwalia GS, Gharehbaghi K, Covey JM, Hochman I, Paull KD, Jayaram HN.
Studies on the mechanism of action of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) in mammalian lymphoblasts.
J Exp Ther Oncol. 1: 191-203, 1996. [Journal]
53)  Ezzitouni A, Barchi JJ, Marquez VE.
A Simple Approach to 1',1'A-Methano Carbocyclic Thymidine.
J Chem Soc Chem Comm. 13: 1345-1346, 1995. [Journal]
54)  Burke TR, Barchi JJ, George C, Wolf G, Shoelson SE, Yan X.
Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors.
J Med Chem. 38: 1386-96, 1995. [Journal]
55)  Barchi JJ, Russ P, Johnson B, Otaka A, Nomizu M, Yamada Y.
Glycosylation of the Active Sequence SER-ILE-LYS-VAL-ALA-VAL from the Alpha-1 Chain of Laminin Reduces Tumor-Cell Attachment.
Bioorg & Med Chem Lett. 5: 711-714, 1995. [Journal]
56)  Barchi JJ, Cooney DA, Hao Z, Weinberg ZH, Taft C, Marquez VE, Ford H.
Improved synthesis of zebularine [1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one] nucleotides as inhibitors of human deoxycytidylate deaminase.
J Enzyme Inhib. 9: 147-62, 1995. [Journal]
57)  Kazanietz MG, Barchi JJ, Omichinski JG, Blumberg PM.
Low affinity binding of phorbol esters to protein kinase C and its recombinant cysteine-rich region in the absence of phospholipids.
J Biol Chem. 270: 14679-84, 1995. [Journal]
58)  Lee J, Barchi JJ, Marquez VE.
Synthesis of a Rigid Diacylglycerol Analog Having a Bis-gamma-butyrolactone Skeleton Separated by a Cyclopentane Ring.
Chem Lett. 4: 299-300, 1995. [Journal]
59)  Siddiqui MA, Marquez VE, Driscoll JS, Barchi JJ.
A Diastereoselective Synthesis of (S,S)-alpha-Fluoro-2,2-dimethyl-1,3,-dioxolane-4-propanoic Acid Methyl Ester, a Key Intermediate for the Preparation of Anti-HIV Effective Fluorodideoxynucleosides.
Tet Lett. 35: 3263-3266, 1994. [Journal]
60)  Rodriguez JB, Marquez VE, Nicklaus MC, Mitsuya H, Barchi JJ.
Conformationally locked nucleoside analogues. Synthesis of dideoxycarbocyclic nucleoside analogues structurally related to neplanocin C.
J Med Chem. 37: 3389-99, 1994. [Journal]
61)  Gharehbaghi K, Paull KD, Kelley JA, Barchi JJ, Marquez VE, Cooney DA, Monks A, Scudiero D, Krohn K, Jayaram HN.
Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase.
Int J Cancer. 56: 892-9, 1994. [Journal]
62)  Barchi JJ, Grasberger B, Gronenborn AM, Clore GM.
Investigation of the backbone dynamics of the IgG-binding domain of streptococcal protein G by heteronuclear two-dimensional 1H-15N nuclear magnetic resonance spectroscopy.
Protein Sci. 3: 15-21, 1994. [Journal]
63)  Roller PP, Otaka A, Nomizu M, Smyth MS, Barchi JJ, Burke TR, Case RD, Wolf G, Shoelson SE.
Norleucine as a Replacement for Methionine in Phosphatase-Resistant Linear and Cyclic-Peptides which Bind to P85 SH2 Domains.
Bioorg & Med Chem Lett. 4: 1879-1882, 1994. [Journal]
64)  Bodenteich M, Marquez VE, Barchi JJ, Hallows WH, Goldstein BM, Driscoll JS.
Synthesis of Carbocyclic Analogs of 1-beta-D-Psicofuranosyl Nucleosides - Psico-cyclopentenyladenosine (Psicoplanocin-A) and Psico-cyclopentenylcytosine.
J Org Chem. 58: 6009-6015, 1993. [Journal]
65)  Rodriguez JB, Marquez VE, Nicklaus MC, Mitsuya H, Barchi JJ.
Synthesis of Cyclopropane-fused Dideoxycarbocyclic Nucleosides Structurally Related to Neplanocin-C.
Tet Lett. 34: 6233-6236, 1993. [Journal]
66)  Siddiqui MA, Driscoll JS, Marquez VE, Roth JS, Shirasaka T, Mitsuya H, Barchi JJ, Kelley JA.
Chemistry and anti-HIV properties of 2'-fluoro-2',3'-dideoxyarabinofuranosylpyrimidines.
J Med Chem. 35: 2195-201, 1992. [Journal]
67)  Teng K, Marquez VE, Milne GWA, Barchi JJ, Kazanietz MG, Lewin NE, Blumberg PM, Abushanab E.
Conformationally Constrained Analogues of Diacylglycerol - Interaction of Gamma-lactones with the Phorbol Ester Receptor of Protein-Kinase-C.
J Am Chem Soc. 114: 1059-1070, 1992. [Journal]
68)  Barchi JJ, Haces A, Marquez VE, McCormack JJ.
Inhibition of Cytidine Deaminase by Derivatives of 1-(beta-D-Ribofuranosyl)-dihydropropyrimidin-2-one (Zebularine).
Nucleosides & Nucleotides. 11: 1781-1793, 1992. [Journal]
69)  Russ PL, Hegedus L, Kelley JA, Barchi JJ, Marquez VE.
The Controlled Stereospecific Reduction of Cyclopentenyl Cytosine (CPE-C) to Carbodine and Isocarbodine.
Nucleosides & Nucleotides. 11: 351-363, 1992. [Journal]
70)  Barchi JJ, Musser S, Marquez VE.
The Decomposition of 1-(beta-D-Ribofuranosyl)-1,2-Dihydropyrimidin-2-one (Zebularine) in Alkali - Mechanism and Products.
J Org Chem. 57: 536-541, 1992. [Journal]
71)  Wysocki RJ, Siddiqui MA, Barchi JJ, Driscoll JS, Marquez VE.
A More Expedient Approach to the Synthesis of Anti-HIV-Active 2,3-Dideoxy-2-fluoro-beta-D-threo-pentafuranosyl Nucleosides.
Synthesis-Stuttgart. 11: 1005-1008, 1991. [Journal]
72)  Driscoll JS, Marquez VE, Plowman J, Liu PS, Kelley JA, Barchi JJ.
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
J Med Chem. 34: 3280-4, 1991. [Journal]
73)  Driscoll JS, Marquez VE, Plowman J, Liu PS, Kelley JA, Barchi JJ.
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
J Med Chem. 34: 3280-4, 1991. [Journal]
74)  Barchi JJ, Marquez VE, Driscoll JS, Ford H, Mitsuya H, Shirasaka T, Aoki S, Kelley JA.
Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugs.
J Med Chem. 34: 1647-55, 1991. [Journal]
75)  Barchi JJ, Marquez VE, Driscoll JS, Ford H, Mitsuya H, Shirasaka T, Aoki S, Kelley JA.
Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugs.
J Med Chem. 34: 1647-55, 1991. [Journal]
76)  Barchi J, Rittenhouse-Olson K, Svarovsky S, inventor; DHHS, assignee.
Carbohydrate Antigen-nanoparticle Conjugates And Uses Thereof As Antimetastatic Agents In Treating Cancer.
Patent Pending, Filed in 2005. Application No. 10/578,385. Pending [Patent]
77)  Barchi J, Svarovsky S, inventor; DHHS, assignee.
Discovery Of A Novel Method For The Preparation Of Carbohydrate-encapsulated Quantum Dots For Cell-specific Biological Imaging.
Patent Pending, Filed in 2003. Application No. 10/578,405. Pending [Patent]
78)  Barchi J, Svarovsky S, inventor; DHHS, assignee.
Preparation Of Polyethylene Glycol (peg)-containing Carbohydrate-encapsulated Hybrid Quantum Dots For Biological Imaging.
Patent Pending, Filed in 2004. Application No. 10/594,075. Pending [Patent]

This page was last updated on 9/24/2008.