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Copyright © 2008 Ly et al, publisher and licensee Dove Medical Press Ltd. Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time Correspondence: Shmuel Shoham Washington Hospital Center, Section of Infectious Diseases, 110 Irving Street NW, 2A56, Washington DC, 20010, USA Tel +1 202 877 7164 Email shmuel.shoham/at/medstar.net | ||||
Abstract Fluorescence in situ hybridization using peptide nucleic acid probes (PNA-FISH) differentiates Staphylococcus aureus from other Gram-positive-cocci in clusters (GPCC). 101/202 patients with GPCC+ blood cultures were randomly assigned to clinician-notification of PNA FISH results. Notification was associated with reduced mortality (8% vs.17%, p = 0.05), further antibiotic use (median −2.5 days, p = 0.01), and trended toward reduced hospital stay and charges. | ||||
