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Abstract
Grant Number: 1P20RR020750-01 Project Title: COGNITIVE PHENOTYPING:NEUROPSYCHIATRIC THERAPEUTICS(RMI)
PI Information: Name Title BILDER, ROBERT M. rbilder@mednet.ucla.edu PROFESSOR Abstract: DESCRIPTION (provided by applicant): The exploratory Center for Cognitive Phenomics (CCP) aims to accelerate identification and efficient measurement of cognitive phenotypes across syndromes and across species to advance interdisciplinary research on neuropsychiatric therapeutics. Cognitive abnormalities have been identified in all major neuropsychiatric disorders, offer quantitative phenotypes for genomic studies and clinical trials, and provide strong bridging relations to neural systems models. The CCP will iteratively refine cognitive phenotypes in interdisciplinary research using neurobehavioral, neuroimaging, and neuropsychopharmacological approaches to provide translational validation of physiological endophenotypes. The CCP will coordinate activities of a large group of experts at UCLA and elsewhere to: (1) generate cross-disorder and cross-species catalogs of phenotypes; (2) develop a phenotype selection algorithm to identify the most promising candidates for research; (3) design a phenomics database for empirical data representation, data mining, and hypothesis testing; and (4) support proof of- concept pilot projects. To advance these aims the CCP will initiate core services for: High Throughput Cognitive Phenotyping; Neuroimaging; and Translational Neuropsychopharmacology. The CCP will initially leverage UCLA campus-wide resources to provide bridging infrastructure and expertise in: Genomics, Pharmacogenomics and Statistical Genetics; Biostatistics and Psychometrics; Bioinformatics; Clinical Trial Design and Regulatory Affairs; and Bioethics. The CCP aims to overcome bottlenecks in the discovery of treatments for neuropsychiatric syndromes that are caused by the use of traditional behavioral "symptom" phenotypes, which are heterogeneous and overlapping, and difficult to translate to basic research. The long-term goal is establishment of a mature CCP that will provide the international research community with efficient, well validated phenotype assays; a cognitive phenomics data repository linked to genomics, proteomics, and other biological knowledge-bases; and novel strategies for interdisciplinary research on neuropsychiatric therapeutics.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
biomedical registry /referral center, cognition disorder, computational neuroscience, disease /disorder classification, health science research support, informatics, interdisciplinary collaboration, phenotype, psychotherapy
clinical research
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES Office of Research Administration LOS ANGELES, CA 90095 Fiscal Year: 2004 Department: NONE Project Start: 28-SEP-2004 Project End: 31-JUL-2007 ICD: NATIONAL CENTER FOR RESEARCH RESOURCES IRG: ZRR1