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Your search term(s) "acromegaly" returned 9 results.

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Acromegaly. Bethesda, MD: National Endocrine and Metabolic Diseases Information Service. 2008. 10 p.

This fact sheet, from the National Endocrine and Metabolic Diseases Information Service (NEMDIS), describes acromegaly, a hormonal disorder that results from too much growth hormone (GH) in the body. Usually, the excess GH comes from benign, or noncancerous, tumors on the pituitary gland. The fact sheet is written in a question-and-answer format and covers the causes of acromegaly, the symptoms of this disorder, pituitary and nonpituitary tumors, the incidence of acromegaly, diagnostic tests used to confirm the condition, and treatment options, including surgical removal of the tumor, medical therapy, and radiation therapy of the pituitary. Common features of acromegaly include abnormal growth of the hands and feet; bone growth in the face that leads to a protruding lower jaw and brow and an enlarged nasal bone; joint aches; thick, coarse, oily skin; and enlarged lips, nose, and tongue. Acromegaly can cause sleep apnea, fatigue and weakness, headaches, impaired vision, menstrual abnormalities in women, and erectile dysfunction in men. Acromegaly is diagnosed through a blood test. Magnetic resonance imaging (MRI) of the pituitary is then used to locate and detect the size of the tumor causing GH overproduction. The fact sheet concludes with a list of three resource organizations through which readers can get more information and a brief description of the activities of the NEMDIS. 1 figure. 9 references.

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Acromegalia (Acromegaly). Chevy Chase, MD: Hormone Foundation. 2007. 1 p.

This brief Spanish-language fact sheet explains acromegaly, a rare condition caused by too much growth hormone (GH) in the blood. GH is released by the pituitary gland, and the blood carries it to other parts of the body, such as bone and muscle. The fact sheet answers common questions about acromegaly, including its causes, the signs and symptoms of the condition, diagnostic tests that confirm the diagnosis of acromegaly, and treatment options. Acromegaly is caused by a noncancerous tumor in the pituitary gland that produces too much GH and raises the level of GH in the blood. Too much GH raises the level of a hormone called insulin-like growth factor 1 (IGF-1). Diagnostic tests include blood tests, oral glucose tolerance tests, and imaging studies such as magnetic resonance imaging (MRI). Treatment can include surgery, pituitary irradiation, medication, or a combination of these options. Readers are referred to the Hormone Foundation’s website at www.hormone.org for more information. The fact sheet is also available in English. 1 figure. 4 references.

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Acromegaly. Chevy Chase, MD: Hormone Foundation. 2007. 1 p.

This brief fact sheet explains acromegaly, a rare condition caused by too much growth hormone (GH) in the blood. GH is released by the pituitary gland, and the blood carries it to other parts of the body, such as bone and muscle. The fact sheet answers common questions about acromegaly, including its causes, the signs and symptoms of the condition, diagnostic tests that confirm the diagnosis of acromegaly, and treatment options. Acromegaly is caused by a noncancerous tumor in the pituitary gland that produces too much GH and raises the level of GH in the blood. Too much GH raises the level of a hormone called insulin-like growth factor 1 (IGF-1). Diagnostic tests include blood tests, oral glucose tolerance tests, and imaging studies such as magnetic resonance imaging (MRI). Treatment can include surgery, pituitary irradiation, medication, or a combination of these options. Readers are referred to the Hormone Foundation’s website at www.hormone.org for more information. The fact sheet is also available in Spanish. 1 figure. 4 references.

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Endocrine Hypertension. IN: Gardner, D.; Shoback, D., eds. Greenspan’s Basic and Clinical Endocrinology. 8th ed. Columbus, OH: McGraw Hill. 2007. pp 396-420.

This chapter about endocrine hypertension is from a textbook about endocrinology that describes the scientific principles and clinical management of patients with endocrine-related diseases and disorders. The authors note that although the kidney is not an endocrine organ per se, its role as both the origin of and target tissue for the hormones that comprise the renin-angiotensin-aldosterone system make hypertensive disorders of kidney origin an appropriate subject for a chapter on endocrine hypertension. Hypertension can be a prominent feature of other endocrine disorders, including acromegaly, thyrotoxicosis, hypothyroidism, and hyperparathyroidism, but these are discussed elsewhere in the text. In this chapter, the authors discuss the synthesis, metabolism, and action of mineralocorticoid hormones; the pathogenesis of mineralocorticoid hypertension; aldosterone and the heart; primary aldosteronism; syndromes due to excess deoxycorticosterone production; Cushing’s syndrome; pseudohyperaldosteronism; hypertension of renal origin; the renin-angiotensin system and hypertension; and other hormone systems and hypertension, including insulin, the natriuretic peptides, nitric oxide, endothelin, the kallikrein-kinin system, and the sympathetic nervous system. The chapter includes numerous black-and-white photographs and illustrations; a list of abbreviations is provided. 11 figures. 1 table. 15 references.

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Hypothalamic-Pituitary Disorders. IN: Camacho, P.M.; Gharib, H.; Sizemore, G.W., eds. Evidence-Based Endocrinology. 2nd ed. Philadelphia, PA: Lippincott Williams and Wilkins. 2007. pp 1-29.

This chapter on hypothalamic-pituitary disorders is from a concise, reference-based handbook that is intended to help busy clinicians with endocrine-related diagnostic and therapeutic decisions required in their practices. Using a modification of the McMaster criteria, the contributors to the text have critically assessed and graded studies, assisting readers in quickly evaluating the articles that have led to practice recommendations. Topics covered in this chapter include evaluation of the hypothalamic-pituitary axis, imaging of the hypothalamic-pituitary system, pituitary tumors, hypopituitarism, disorders of the prolactin system, acromegaly, Cushing disease, diabetes insipidus, and the syndrome of inappropriate antidiuretic hormone secretion. For each disease state included, the authors discuss etiology, epidemiology, pathophysiology, diagnosis, and treatment considerations. The chapter includes an outline and an extensive, annotated list of references. 3 tables. 78 references.

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Pathogenesis. IN: Scobie, I.N. Atlas of Diabetes Mellitus. 3rd ed. New York, NY: Informa Healthcare USA. 2007. pp 9-32.

This chapter about pathogenesis is from an atlas of diabetes mellitus that offers text and pictures to familiarize clinicians with the most current information about diabetes, its diagnosis, and its treatment. The volume portrays the wide and varied expressions of diabetes and its complications as an aid to their more ready recognition in clinical practice. This chapter discusses type 1 diabetes; type 2 diabetes; other types of diabetes, including maturity-onset diabetes of the young (MODY); the obesity epidemic; and prevention of the different types of diabetes. The chapter offers full-color photographs of specific presentations of diabetes in conjunction with other diseases and genetic disorders, including Cushing’s syndrome, Prader-Willi syndrome, obesity, acromegaly, Addison’s disease, hemochromatosis, Klinefelter’s syndrome, Turner’s syndrome, myotonic dystrophy, and Rabson-Mendenhall syndrome. Additional illustrations present the biochemical consequences of insulin deficiency, mechanisms of glucose production and stimulation, histology of the pancreas and beta cells, and pathology of the pancreas. 44 figures. 20 references.

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American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Acromegaly. Endocrine Practice. 10(3): 214-225. May-June 2004.

This article presents the position statement of the American Association of Clinical Endocrinologists (AACE) on the diagnosis and management of acromegaly, a condition characterized by hypersecretion of growth hormone (GH). The authors caution that acromegaly is a chronic disease with a slowly progressive nature that can often remain undetected for up to 10 years. This delay in diagnosis can exacerbate the complications due to GH hypersecretion. This article first reviews the symptoms of acromegaly, which can include headache, fatigue, visual field loss, hypertension, excessive perspiration, and sleep apnea syndrome. The guidelines then review diagnostic strategies; the role of surgical therapy; candidates for surgical treatment; prognostic factors; the role of medical therapy with somatostatin analogues, GH receptor antagonists, and dopamine agonists; the role of radiation treatment, and monitoring and treating comorbidities, including skeletal and dental problems, hypopituitarism, respiratory disorders, cardiovascular disease, and cancer. The guidelines stress that surgical treatment remains the first management option for virtually all patients with acromegaly. However, because complete resection is not always possible, adjunctive therapy is frequently necessary. 1 figure. 3 tables. 73 references.

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Endocrinology. New York, NY: Elsevier Science, Inc. 2003. 737 p.

This book on endocrinology is from a series that provides the latest on evaluation, diagnosis, management, outcomes and prevention. The book offers concise, action-oriented recommendations for primary care medicine. It includes MediFiles (sections) on acromegaly, Addison's disease (hypoaldosteronism), Cushing's syndrome, diabetes insipidus, type 1 diabetes mellitus, type 2 diabetes mellitus, diabetic ketoacidosis, Gilbert's disease, gynecomastia, hirsutism, hypercalcemia, hyperkalemia, hyperthyroidism, hypocalcemia, hypokalemia, hyponatremia, hypopituitarism, hypothyroidism, Klinefelter's syndrome, osteomalacia and rickets, osteoporosis, pheochromocytoma, polycystic ovarian syndrome, precocious puberty, thyroid carcinoma, thyroid nodule, thyroiditis, and Turner's syndrome. Each MediFile covers summary information and background on the condition, and comprehensive information on diagnosis, treatment, outcomes, and prevention. Each section concludes with a list of resources.

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Secondary Forms and Genetic Syndromes of Diabetes Mellitus. In: Leahy, J.L.; Clark, N.G.; Cefalu, W.T. Medical Management of Diabetes Mellitus. Monticello, NY: Marcel Dekker, Inc. 2000. p. 217-233.

Hyperglycemia (high levels of blood glucose) or impaired glucose tolerance is a feature of a large number of illnesses and genetic syndromes that are collectively termed secondary forms of diabetes. Type 1 and type 2 diabetes make up the vast majority of cases seen by primary care physicians. Although many of the secondary forms are rare, each has characteristic clinical features that are of diagnostic value, and practicing physicians must have some familiarity and a high index of suspicion. This chapter on secondary forms and genetic syndromes of diabetes mellitus is from a textbook for practicing providers and for physicians in training that offers a comprehensive, up-to-date overview of diabetes mellitus. The authors of this chapter cover genetic defects of beta-cell function, including maturity-onset diabetes of the young (MODY syndromes) and mitochondrial DNA mutations; defects in insulin action, including type A insulin resistance, type A syndrome subtypes, variant of type A syndrome, lipoatrophic diabetes, and type B insulin resistance; diseases of the exocrine pancreas, including acute and chronic pancreatitis, cystic fibrosis, hemochromatosis, and malnutrition-related diabetes, i.e., fibrocalculous pancreatopathy; and endocrinopathies, including acromegaly, Cushing's syndrome, glucagonoma, pheochromocytoma, thyrotoxicosis, somatostatinoma, and aldosteronoma. 1 table. 19 references.

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