Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health www.cancer.gov
CCR - For Our Staff| Home |

Our Science – LMC Website

Laboratory of Medicinal Chemistry

Gallery Pictures
PNAS cover article graces the CCR-OD Conference Room
PNAS cover article graces the CCR-OD Conference Room
The lowest energy-binding conformation of an inhibitor bound to the dimeric interface of HIV-1 integrase core domain. The yellow region represents a unique allosteric binding site identified by affinity labeling and mass spectrometry and validated through mutagenesis. This site can provide a potential platform for the rational design of inhibitors selective for disruption of integrase multimerization. See the article by Al-Mawsawi et al. in this issue [PNAS 2006 103: 10080–10085].
NAR cover article selected by Dr. Wiltrout
NAR cover article selected by Dr. Wiltrout
HHAI methyltransferase (blue ribbon) bound to oligonucleotide (strands with bonds colored yellow and green) containing a pseudorotationally constrained sugar analogue at the target position (orange bonds with cyan atoms). The south-constrained pseudosugar is rotated about its flanking phosphodiester bonds, 90° from its initial position in B-form DNA, but short of a completely flipped position with 180° rotation. Thus, it is trapped in the middle of the flipping pathway via the major groove side. This structure provides clues to DNA-protein interactions in a potential transition state. For further details see the paper by Horton et al. in this issue [Nucleic Acids Res. (2004) 32, 3877-3886].
Dr. Oyinda Oyelaran Receives the 2007 NCI Director's Innovation Award
Dr. Oyinda Oyelaran Receives the 2007 NCI Director
Congratulations to Dr. Oyinda Oyelaran on receiving the 2007 NCI Director's Innovation Award. Dr. Oyelaran accepts the award from NCI Director, Dr. John E. Niederhuber.
Dr. Joseph Barchi receives Midwest Carbohydrate & Glycobiology Symposium Award
Dr. Joseph Barchi receives Midwest Carbohydrate & Glycobiology Symposium Award
Dr. Barchi receiving his "2007 Best-Dressed & Most Elegant" award from Dr. Jeff Gildersleeve (National Cancer Institute).
Dr. Andreas Sundgren receives Midwest Carbohydrate & Glycobiology Symposium Award
Dr. Andreas Sundgren receives Midwest Carbohydrate & Glycobiology Symposium Award
Dr. Andreas Sundgren of the National Cancer Institute being presented the "2007 Outstanding Poster Presentation" award by Dr. George O'Doherty (West Virginia University).

This page was last updated on 10/16/2007.