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Abstract
Grant Number: 1R03MH083077-01 Project Title: Identification of Modulators of the TRPML3 and TRPN1 ion Channels
PI Information: Name Title HELLER, STEFAN hellers@stanford.edu ASSOCIATE PROFESSOR Abstract: DESCRIPTION (provided by applicant): The main goal of this project lies in identifying agonists for two transient receptor potential (TRP) ion channels that are potentially involved in inner ear mechanosensation. One of the major obstacles of inner ear biology is the lack of specific pharmacological tools to investigate the process of mechanotransduction of inner ear sensory hair cells. Although the vertebrate hair cell transduction channel remains a mystery, a number of TRPs are connected to a potential physiological function in the inner ear. Particularly TRPML3 and TRPN1, the focus of this application, have been shown to be important for hearing and balance in mice and zebrafish. Identification of agonists and, in future studies prospective antagonists, would not only advance inner ear and sensory neurobiology, but could also provide us with potential drug candidates for the treatment of vertigo and tinnitus.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
high throughput technology, labyrinth, membrane channel, stimulant /agonist
biological signal transduction, sensory mechanism
NIH Roadmap Initiative tag, cell line, voltage /patch clamp
Institution: STANFORD UNIVERSITY STANFORD, CA 94305 Fiscal Year: 2007 Department: OTOLARYNGOLOGY-HEAD & NECK SURGERY Project Start: 29-SEP-2007 Project End: 31-AUG-2008 ICD: NATIONAL INSTITUTE OF MENTAL HEALTH IRG: ZMH1