| Version 2.5.2.0 |
|
|
Abstract
Grant Number: 1R21NS053726-01 Project Title: Fluorescence Polarization Assay-Methyltransferases(RMI)
PI Information: Name Title YE, QI-ZHUANG yeq@iupui.edu ASSOCIATE PROFESSOR Abstract: DESCRIPTION (provided by applicant): Methylation is vital in many biological processes, and potent and specific inhibitors of methyltransferases are valuable tools in understanding these processes. Some positive clinical and preclinical results from DMA methyltransferase inhibitors indicate the potential use of these inhibitors in cancer therapy. In this proposal, we intend to develop a fluorescence polarization assay which is non-radioactive and amenable to high throughput screening. This will greatly facilitate the discovery of novel inhibitors of methyltransferases by high throughput screening. These inhibitors will be not only valuable research tools to study the large family of important enzymes but also initial leads to develop future drugs for cancer and other diseases.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
drug discovery /isolation, drug screening /evaluation, enzyme inhibitor, fluorescence polarization, high throughput technology, methyltransferase, technology /technique development
S adenosylmethionine, bacterial protein, homocysteine
biotechnology
Institution: UNIVERSITY OF KANSAS LAWRENCE 2385 IRVING HILL ROAD LAWRENCE, KS 660457563 Fiscal Year: 2005 Department: MEDICINAL CHEMISTRY Project Start: 30-SEP-2005 Project End: 31-JUL-2006 ICD: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE IRG: ZNS1