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The following instructions are unique to multiproject grants. For other items, follow the PHS 398 instructions.
Introduce each project using the PHS 398 Continuation Page; do not use the Face Page form.
Give each research project a number, e.g., 1, 2, 3, and a unique title. For easy cross-referencing, put the project's number and title on the upper left margin of all relevant pages.
The cover page should contain only the following items:
- Project Number and Title: e.g., 1. Preclinical Evaluation of HIV Microbicides
- Name of Project Leader: e.g., Jones, Roberta A.
- Human Subjects: Yes or No
If yes, exemption number
or
IRB approval date or "pending"
and
Federalwide Assurance number
- Vertebrate Animals: Yes or No
If Yes, IACUC approval date or "pending"
and
Animal welfare assurance number
- Proposed Period of Support
From: mmddyy, e.g., 07/01/07
To: mmddyy, e.g., 06/30/12
- Costs Requested for Initial Budget Period: e.g., 07/01/07 to 06/30/08
Direct costs: e.g., $150,000
Total costs: e.g., $162,000
- Costs Requested for Entire Budget Period: e.g., 07/01/07 to 06/30/12
Direct costs: e.g., $700,000
Total costs: e.g., $785,000
- Applicant Organization: Full name and address
Form Page 2
Provide a description, an abstract of the proposed research. The abstract should also briefly describe how the project will contribute to attaining the objectives of the overall program.
List the performance sites that will conduct the research.
Under "key personnel," list the project leader followed by the other key personnel and then other significant contributors.
Form Page 3
Prepare a table of contents for each project application.
Biographical Sketch Format Page
Do not include biographical sketches; they go in the overall application and its table of contents only.
Research Plan
Items 2 to 5 are limited to 25 pages.
- Item 2 -- Specific Aims: List in priority order the project's objectives and goals. Concisely and realistically describe the hypothesis or hypotheses to be tested. State the project's relationship to the multiproject program's goals and the other projects or cores. This section is typically one page.
- Item 3 -- Background and Significance: Use this section to describe how the proposed research will contribute to meeting the program's goals and objectives and explain the rationale for selecting the methods to accomplish the Specific Aims. In addition to stating the biological significance of the research, indicate the project's relevance to the primary theme of the application.
- Item 4 -- Preliminary Studies/Progress Report: Follow the approach best suited to your application.
- For new applications, present your data and analyze its importance to the project. Be sure to include preliminary data that helps reviewers assess the likelihood of success.
- For renewals, prepare a progress report that summarizes your progress towards achieving the specific aims, explains the importance of your findings, and gives an account of published and unpublished results. Discuss any changes in the project's budget or science.
- Item 5 -- Research Design and Methods: Describe the research design, procedures, experiments, and materials necessary to accomplish the specific aims. Discuss potential problems with your approach and present alternatives. Justify your proposed techniques and explain how they are better than the existing technology. Provide a timetable with contingency plans.
Appendix
Do not create an Appendix for a project as the whole application will have only one Appendix.
Introduction for a Resubmission
If you need to resubmit, include an introduction of up to three pages for each project to address reviewers' comments.
Note: you must request permission from your program officer to resubmit your application.
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