Mapping Gene Regulatory Pathways by Assembly of Physical and Genetic Interactions
 


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Air date: Tuesday, February 19, 2008, 2:00:00 PM
Category: Systems Biology
Runtime: 60 minutes
NLM Title: Mapping gene regulatory pathways by assembly of physical and genetic interactions [electronic resource] / Trey Ideker.
Author: Ideker, Trey.
National Institutes of Health (U.S.). Systems Biology Special Interest Group.
Publisher: [Bethesda, Md. : National Institutes of Health, 2008]
Abstract: (CIT): Physical and genetic mapping data have become as important to Network Biology as they were to the Human Genome Project. Physical interaction maps are being constructed through systematic measurements of protein-protein, protein-DNA, and protein-small molecule interactions. Genetic interaction maps are being generated by large-scale screening of synthetic-lethals and epistasis, by multipoint gene association studies, and by mapping the effects of natural and prescribed genetic variations on gene expression. We are working on ways of integrating physical and genetic interaction maps to assemble models of gene regulatory pathways. These efforts face several challenges, including: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information. Efforts in each of these areas will be described. Using integrative tools, we are constructing network models to explain the physiological response of yeast to DNA damaging agents.
Subjects: Chromosome Mapping
Computational Biology--methods
Gene Expression Regulation
Gene Regulatory Networks--genetics
Publication Types: Government Publications
Lectures
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NLM Classification: QU 450
NLM ID: 101468731
CIT File ID: 14305
CIT Live ID: 6595
Permanent link: http://videocast.nih.gov/launch.asp?14305