Mark Udey, MD, PhD
Entry Id: TP-54

Eligibility Criteria
Qualified candidates must have two years of dermatology residency credit from an approved United States (US) or Canadian dermatology program.

Overview
The Dermatology Branch of the NCI offers unique opportunities in clinical and laboratory research through a two-year appointment as a Clinical Associate. The branch is staffed by dermatologists, molecular biologists, cell biologists, immunologists, and biochemists active in the training of clinical and basic researchers. This is a dynamic program combining state-of-the-art research with a broad range of clinical topics.

Structure of the Clinical Training Program
Before beginning the Dermatology Program at NIH, residents choose a senior staff advisor and laboratory for their two- to three-year fellowship. For a period of four to six months the trainee has responsibility for the dermatologic consultation service supporting the NIH Clinical Center. These consultations occur under the supervision of a board-certified dermatologist. The NIH Clinical Center is a 250-bed hospital, with broad clinical exposure. The Dermatology Branch is heavily weighted in the areas of immunological and inflammatory skin diseases, neoplastic diseases, keratinizing disorders, and DNA-repair defects.

Structure of the Research Training Program
In the first year, trainees begin the research projects that are continued full-time in the second and perhaps subsequent years. The Dermatology Branch studies the growth and differentiation of epithelium and lymphoreticular tissues in normal, hyperplastic, neoplastic and inflammatory states. The research activities of the branch are divided into several major areas, as indicated in the description of faculty research interests.

• Dr. Stephen Katz. The role of skin as an immunological organ; the immunopathologic mechanisms involved in various immunological, inflammatory, and lymphoproliferative skin diseases.
• Dr. Mark Udey. The role that essential fatty acids or their metabolites play in the regulation of accessory cell function in the skin; the mechanism by which ultraviolet light inhibits antigen presentation by epidermal cells; immunological, inflammatory, and lymphoproliferative diseases.
• Dr. Jay Robbins. Studies of DNA repair in normal human cells and in cells from Xeroderma pigmentosum patients.
• Dr. Douglas R. Lowy, Chief, Laboratory of Cellular Oncology. Studies involving the biological activity of oncogenic viruses, including papilloma virus.
• Dr. Jonathan Vogel. Studies in vitro and in vivo gene therapy techniques using skin.

Examples of Papers Authored by Program Faculty

• Stanley JR, Tanaka TT, Mueller SM, Klaus-Kovtun V, Roop D. Isolation of cDNA for bullous pemphigoid antigen by use of patients' autoantibodies. J Clin Invest 1988;82:1864-1870.Aiba A, Katz SI. Phenotypic and functional characteristics of in vivo activated Langerhans cells. J Immunol 1990;145:2791-2796.
• Hauser C, Katz SI. Generation and characterization of T helper cells by primary in vitro sensitization using Langerhans cells. Immunol Rev 1990;117:67-84.
• Tang A, Udey MC. Inhibition of epidermal Langerhans cell function by low dose ultraviolet B radiation. J Immunol 1991;146:3347-3355.
• Tanaka T, Parry DAD, Klaus-Kovtun V, Steinert P, Stanley JR. Comparison of molecularly cloned bullous pemphigoid antigen to desmoplakin I confirms that they define a new family of cell adhesion junction plaque proteins. J Biol Chem 1991;266:12555-12559.

Program Graduates
The following is a list of recent graduates including their current positions:

Completed Program 1983

• Dr. Jo David Fine. Professor, University of North Carolina, Chapel Hill, North Carolina.

Completed Program 1987

• Dr. Elliot Androphy. Associate Professor, Tufts University, Boston, Massachusetts.
• Dr. Kevin Cooper. Associate Professor, University of Michigan, Ann Arbor, Michigan.

Completed Program 1989

• Dr. S. Wright Caughman. Associate Professor, Emory University, Atlanta, Georgia.
• Dr. Anthony Gaspari. Assistant Professor, University of Rochester, Rochester, New York.
• Dr. Neil Korman. Assistant Professor, Case Western Reserve University, Cleveland, Ohio.

Completed Program 1990

• Dr. Carol McNeely. Assistant Professor, George Washington University, Washington, District of Columbia.

The Dermatology Program is accredited for one year of residency training in dermatology by the Accreditation Council for Graduate Medical Education. This year must follow two years of dermatology training at an approved U.S. or Canadian dermatology program. This program is also approved for a one-year fellowship in dermatological immunology/diagnostic and laboratory immunology by the American Board of Dermatology.

Qualified candidates must have two years of dermatology residency credit. Upon completion of a third year of dermatology training in this program, fellows are eligible to sit for the board exam in dermatology. There are approximately two to three positions available per year, and candidates should apply one to one and a half years in advance. The length of stay for trainees participating in the program is a minimum of two years; most stay three to four years.

Electronic Application
The quickest and easiest way to find out more about this training program or to apply for consideration is to do it electronically.

The NIH is dedicated to building a diverse community in its training and employment programs.