Press Center
Federal Register: Projected NTP Review Schedule
[Federal Register: June 10, 1996 (Volume 61, Number 112)]
[Notices]
[Page 29413-29415]
[[Page 29413]]
Abbreviations used: in this report:
[Notices]
[Page 29413-29415]
[[Page 29413]]
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program (NTP) Board of Scientific Counselors' Meetings; Announcement of NTP Draft Technical Reports Projected for Public Review From December 1996 Through Fall 1998; Request for Public Input
To earlier inform the public and encourage interested parties to comment or obtain information on projected long-term toxicology and carcinogenesis studies prior to public peer review, the National Toxicology Program (NTP) again publishes in the Federal Register a current listing of draft Technical Reports projected for evaluation by the NTP Board of Scientific Counselors' Technical Reports Review Subcommittee during their next five meetings from December 1996 through Fall 1998. We plan to continue updating the listing with announcements in the Federal Register once or twice a year. The next meeting dates are December 11-12, 1996. Specific dates for 1997 and 1998 meetings will be established at a later time.
The attached Table 1 lists draft Technical Reports for long-term studies on chemicals within known or approximate dates of reviews and includes Chemical Abstracts Service (CAS) registry numbers, primary use, route of administration, species, exposure levels, and NTP report numbers (if assigned).
Technical Reports of short-term toxicity studies are currently reviewed by mail; however, they may be reviewed in open meetings when necessary . The attached Table 2 lists the draft Technical Reports of short-term toxicity studies tentatively projected for review by mail from April 1996 to December 1996 and also includes Chemical Abstracts Service (CAS) registry numbers, primary use, route of administration, species, exposure levels, and NTP report numbers (if assigned).
Draft reports are usually available 1-2 weeks before the scheduled date of peer review. At that time copies may be obtained by contacting Central Data Management as early as possible by telephone or by mail at: MD E1-02, NIEHS, P.O. Box 12233, Research Triangle Park (RTP), North Carolina 27709 (919/541-3419) or send e-mail to CDM@niehs.nih.gov. The program would welcome receiving toxicology and carcinogenesis data from completed, ongoing or planned studies by others as well as current production data, human exposure information, and use and use patterns.
The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, Research Triangle Park, North Carolina 27709, telephone 919/541-3971, FAX 919/541-0295 will furnish final agendas and other program information prior to a meeting, and summary minutes subsequent to a meeting.
Attachments
Dated: May 21, 1996
________________________________
Kenneth Olden, Ph.D.
Director
National Toxicology Program
[Billing Code 4140-01]
| CHEMICAL NAME/CAS NUMBER | USE | ROUTE | SPECIES | EXPOSURE LEVELS |
|---|---|---|---|---|
| Chemicals Tentatively Scheduled for Peer Review December 11 - 12, 1996 | ||||
| 3'-AZIDO-3'-DEOXYTHYMIDINE (AIDS) 30516-87-1 | PHAR | GAV | RM | MICE ONLY: 0, 30, 60, OR 120 MG/KG; 50/SEX |
| CHLOROPRENE 126-99-8 | PLAS | INHAL | RM | R&M: 0, 12.8, 32.0, OR 80.0 PPM; 50/SEX/SPECIES/GROUP |
| COBALT SULFATE HEPTAHYDRATE 10026-24-1 | PNT | INHAL | RM | R&M: 0, 0.3, 1.0, OR 3.0 MG/M3; 50/SEX/SPECIES/GROUP |
| TETHYLBENZENE 100-41-4 | RUBR | INHAL | RM | R&M: 0, 75, 250, OR 750 PPM (50/SEX/SPECIES/GROUP) |
| INTERFERON AD + 3'-AZIDO-3'-DEOXYTHYMIDINE (AIDS) | PHAR | SC&GV | MM | DUAL ROUTES WITH BOTH COMPOUNDS: AZT: 0, 30, 60, OR 120 (GAV) MG/KG; IFN: 500 OR 5000 UNITS 3X/WEEK |
| ISOBUTYRALDEHYDE 78-84-2 | INTR | INHAL | RM | R&M: 0, 500, 1000, OR 2000 PPM (50/SEX/SPECIES/GROUP) |
| OXAZEPAM 604-75-1 | PHAR | FEED | R | 0, 625, 1250, 2500, 5000, OR 10000 PPM; 50/SEX/GROUP |
| POLYVINYL ALCOHOL 9002-89-5 | PHAR | IVAG | M | 25% PVA, VEHICLE, UNTREATED;100/GROUP |
| PRIMACLONE (PRIMIDONE) 125-33-7 | PHAR | FEED | RM | M: 0, 0.03, 0.06, OR 0.13% R: 0, 0.06, 0.13, OR 0.25% (50/SEX/SPECIES) |
| TETRAHYDROFURAN 109-99-9 | SOLV | INHAL | RM | R&M: 0, 200, 600, OR 1800 PPM (50/SEX/SPECIES/GROUP) |
| THEOPHYLLINE 58-55-9 | PHAR | GAV | RM | R: 7.5, 25, OR 75 MG/KG; 50/GROUP FM: 7.5, 25, OR 75 MG/KG; 50/GROUP MM: 15, 50, OR 150 MG/KG; 50/GROUP |
| Chemicals Tentatively Scheduled for Peer Review in Summer 1997 | ||||
| 1-CHLORO-2-PROPANOL, TECHNICAL 127-00-4 | INTR | WATER | RM | R: 0, 150, 325, OR 650 PPM M: 0, 250, 500, OR 1000 PPM (50/SEX/GROUP) |
| COCONUT OIL ACID DIETHANOLAMINE CONDENSATE 68603-42-9 | TEXL | SP | RM | R: 0, 50, OR 100 MG/KG M: 0, 100, OR 200 MG/KG (50 SEX/SPECIES/GROUP) |
| DIETHANOLAMINE 111-42-2 | TEXL | SP | RM | MR: 0, 16, 32, OR 64 MG/KG; FR: 0, 8, 16, OR 32 MG/KG; MICE: 0, 40, 80, OR 160 MG/KG (50/SEX/SPECIES/GROUP) |
| FURFURYL ALCOHOL 98-00-0 | FOOD | INHAL | RM | R&M: 0, 2, 8, OR 32 PPM (50/SEX/SPECIES/GROUP) |
| LAURIC ACID DIETHANOLAMINE CONDENSATE 120-40-1 | DTRG | SP | RM | R: 0, 50, OR 100 MG/KG M: 0, 100, OR 200 MG/KG (50/SEX/SPECIES/GROUP) |
| OLEIC ACID DIETHANOLAMINE CONDENSATE 93-83-4 | COSM | SP | RM | R: 0, 50, OR 100 MG/KG; 50/SEX/GROUP M: 0, 15, OR 30 MG/KG; 55/SEX/GROUP |
| PYRIDINE 110-86-1 | SOLV | WATER | RMR | R: 0, 100, 200, OR 400 PPM MM: 0, 250, 500, OR 1000 PPM FM: 125, 250, OR 500 PPM MWR: 0, 100, 200, OR 400 PPM (50/SEX/GROUP) |
| Chemicals Tentatively Scheduled for Peer Review Fall 1997 | ||||
| ETHYLENE GLYCOL MONOBUTYL ETHER (EGMBE) | SOLV | INHAL | RM | R: 0, 31, 62.5, OR 125 PPM M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES |
| ISOBUTENE 115-11-7 | RUBR | INHAL | RM | R&M: 0, 500, 2000, OR 8000 PPM (50/SEX/SPECIES/GROUP) |
| ISOPRENE 78-79-5 | RUBR | INHAL | R | R: 0, 220, 700, OR 7000 PPM; 50/SEX/GROUP |
| PENTACHLOROPHENOL, PURIFIED 87-86-5 | PEST | FEED | R | R: 0, 200, 400, OR 600 PPM; 50/SEX/GROUP - 1000 PPM STOP STUDY (60/SEX) |
| Chemicals Tentatively Scheduled for Peer Review Summer 1998 | ||||
| GALLIUM ARSENIDE 1303-00-0 | ELEC | INHAL | RM | R: 0, 0.01, 0.1, OR 1.0MG/M3; 50/SEX/GROUP M: 0, 0.1, 0.5, OR 1.0 MG/M3; 50/SEX/GROUP |
| METHYLEUGENOL 93-15-2 | FOOD | GAV | RM | R&M: 0, 37, 75, OR 150 MG/KG (50/SEX/SPECIES/GROUP) |
| OXYMETHOLONE 434-07-1 | PHAR | GAV | RM | MR: 0, 3, 30, OR 150 MG/KG; FR: 0, 3, 30, OR 100 MG/KG |
| Chemicals Tentatively Scheduled for Peer Review Fall 1998 | ||||
| INDIUM PHOSPHIDE 22398-80-7 | ELEC | INHAL | RM | R&M: 0, 0.03, 0.1, OR 0.3 MG/M3 |
| CHEMICAL NAME/CAS NUMBER | USE | ROUTE | SPECIES | EXPOSURE LEVELS | TOX# |
|---|---|---|---|---|---|
| Short-Term Toxicity Studies Tentatively Scheduled for Peer Review April 1996 | |||||
| MAGNETIC FIELDS (EMF) (No CAS) | ELEC | WB | RM | 60 HZ MAGNETIC FIELDS - 20 MG, 2 G, 10 G CONTINUOUS AND 10 G NTERMITTENT; 10/GROUP | 58 |
| METHACRYLONITRILE 126-98-7 | PLAS | GAV | RM | R: 0,7.5,15.0,30.0,60.0,120.0 MG/KG/DAY; M: 0,0.75,1.5,3.0, 6.0,12.0 MG/KG/DAY; RATS: 20/GRP; MICE: 10/GRP | 47 |
| METHAPYRILENE HYDROCHLORIDE 135-23-9 | PHAR | FEED | R | MALE RATS: 0, 50, 100, 250, 1000 PPM; 40/GRP | 46 |
| Short-Term Toxicity Studies Tentatively Scheduled for Peer Review May 1996 | |||||
| M-CHLOROANILINE 108-42-9 | INTR | GAV | RM | R&M 0, 10, 20, 40, 80, 160, MG/KG, 20/GRP (RATS); 10/GRP (MICE) | 43 |
| O-CHLOROANILINE 95-51-2 | DYE | GAV | RM | R&M 0, 10, 20, 40, 80, & 160 MG/KG; 20/GRP (RATS);10/GRP (MICE) | 43 |
| Short-Term Toxicity Studies Tentatively Scheduled for Peer Review June 1996 | |||||
| AZT + METHADONE HCL (AIDS) | PHAR | GAV | MM | AZT: 200, 400, OR 800 MG/KG/DAY WITH METHADONE HCL: 5, 15, OR 30 MG/KG/DAY | TBA |
| 2',3'-DIDEOXYCYTIDINE (AIDS INITIATIVE) 7481-89-2 | PHAR | GAV | MM | FEMALE MICE ONLY: 500, 1000 MG/KG/DAY | TBA |
| 3,3',4,4'-TETRACHLOROAZOBENZENE 14047-09-7 | HERB | GAV | RM | R&M: 0, 0.1, 1.0, 3.0, 10, OR 30 MG/KG BODY WEIGHT (M&F; 10/GROUP) | TBA |
| 1,1,2,2-TETRACHLOROETHANE 1,1,2,2-TETRACHLOROETHANE 79-34-5 | SOLV | GAV MICRO | RM | RM R&M; R:UNTREATED CONTROL,VEHICLE CONTROL, 18, 37, 75, 150, OR 300 MG/KG BODY WT/DAY; M:UNTREATED CONTROL, VEHICLE CONTROL, 88, 175, 350, 700, OR 1400 MG/KG BODY WT/DAY; 10/GROUP/SEX | TBA |
| Short-Term Toxicity Studies Tentatively Scheduled for Peer Review August 1996 | |||||
| 1,1,1-TRICHLOROETHANE 71-55-6 | SOLV | MICRO | RM | R&M: 0, 0.5, 1.0, 2.0, 4.0, AND 8.0 % (10/S/S) | 41 |
| Short-Term Toxicity Studies Tentatively Scheduled for Peer Review December 1996 | |||||
| CIS & TRANS 1,2-DICHLOROETHYLENE 540-59-0 | SOLV | MICRO | RM | 55 | |
| CIS-1,2-DICHLOROETHYLENE 156-59-2 | SOLV | MICRO | RM | 55 | |
| TRANS-1,2-DICHLOROETHYLENE 156-60-5 | SOLV | MICRO | RM | 55 | |
| TRANS-1,2-DICHLOROETHYLENE 156-60-5 | SOLV | GAV | RM | 55 | |
| TRANS-1,2-DICHLOROETHYLENE 156-60-5 | SOLV | MICRO | RM | R&M: UNTREATED CONTROL, VEHICLE CONTROL, 3125, 6250, 12500, 25000, OR 50000 PPM; 10/GROUP/SEX | TBA |
Abbreviations used: in this report:
| TBA = | to be assigned |
| USE | Primary Use Category: |
|---|---|
| COMT | Contaminates and/or Impurities |
| COSM | Cosmetics, Perfumes, Fragrances, Hair Preparations |
| DTRG | Detergents and Cleansers |
| DYE | As or in Dyes, Inks, and Pigments |
| ELEC | In Electrical and/or Dielectric Systems |
| FOOD | Food, Beverages, or Additives |
| HERB | Herbicide(s) |
| INTR | Chemical Intermediate or Catalyst |
| PEST | Pesticides, General or Unclassified |
| PHAR | Pharmaceuticals or Intermediates |
| PLAS | As or in Plastics |
| PNT | Paint Ingredient |
| RUBR | Rubber Chemical |
| SOLV | Vehicles and Solvents |
| TEXL | In Manufacture of Textiles |
| ROUTE | Route of Administration: |
|---|---|
| FEED | Dosed-Feed |
| GAV | Gavage |
| INHAL | Inhalation |
| IP/IJ | Intraperitoneal Injection |
| IVAG | Intravaginal |
| MICRO | Microencapsulation in Feed |
| SC&GV | Subcutaneous Inj. + Gavage |
| SP | Topical |
| WATER | Dosed-Water |
| WB | Whole Body Exposure |
| SPEC | Species: |
|---|---|
| R = | Rats |
| M = | Mice |
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