| Topic: | hematologic diseases (he) |
| Title: | Aplastic Anemia and Bone Marrow Failure. |
| Author: | Hoffbrand, A.V.; Moss, P.A.H.; Pettit, J.E. |
| Source: | IN: Hoffbrand, A.V.; Moss, P.A.H.; Pettit, J.E. Essential Haematology. 5th ed. Williston, VT: Blackwell Publishing Inc. 2006. pp. 241-248. |
| Availability: | Available from Blackwell Publishing Inc. P.O. Box 20, Williston, VT 05495. Phone: 1-800-216-2522. Email: orders@aidcvt.com. Website: http://www .blackwellpublishing.com. Price: $45.95. |
| Abstract: | This chapter on aplastic anemia and bone marrow failure is from a hematology textbook that offers a comprehensive look at the biochemical, physiological, and immunological processes involved in normal blood cell formation and function and the disturbances that may occur in different diseases. The authors discuss pancytopenia, aplastic anemia, red cell aplasia, Schwachman-Diamond syndrome, and congenital dyserythropoietic anemias (CDAs). Pancytopenia is a reduction in the blood count of all the major cell lines: red cells, white cells, and platelets. Aplastic, or hypoplastic, anemia is defined as pancytopenia resulting from aplasia of the bone marrow. Fanconi’s anemia is a congenital type of aplastic anemia. Red cell aplasia is a rare syndrome characterized by anemia with normal leucocytes and platelets and grossly reduced or absent erythroblasts in the marrow. Schwachman-Diamond syndrome is a rare autosomal recessive syndrome, characterized by varying degrees of cytopenia. CDAs are a group of hereditary refractory anemias characterized by ineffective erythropoiesis and erythroblast multinuclearity. The chapter features full-color photographs and illustrations. 4 figures. 3 tables. 14 references. |
| Format: | Book Chapter |
| Language: | English. |
| Major Keywords: | Hematologic Diseases. Blood Diseases and Disorders. Blood. Physiology. Pathology. Aplastic Anemia. Erythrocytes. Bone Marrow. |
| Minor Keywords: | Professional Education. Diagnosis. Symptoms. Etiology. Diagnostic Tests. Patient Care Management. Immune System. Fanconi Anemia. Genetic Disorders. Erythropoiesis. Complications. |
| Publication Number: | HEBK10152. |
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