Topic:	hematologic diseases (he)
Title:	Myelodysplastic Syndromes.
Author:	Cahalin, P.A.; Yin, J.A.L.
Source:	IN: Provan, D., ed. ABC of Clinical Haematology. Williston, VT: Blackwell Publishing Inc. 2007. pp 40-44.
Availability:	Available from Blackwell Publishing Inc. P.O. Box 20, Williston, VT 05495. Phone: 1-800-216-2522. Email: orders@aidcvt.com. Website: http://www .blackwellpublishing.com. Price: $44.95.
Abstract:	The myelodysplastic syndromes (MDS) are a group of clonal hemopoietic disorders characterized by ineffective hemopoiesis resulting in anemia and an increased risk of transformation to acute myeloid leukemia (AML). This chapter about MDS is from a book on clinical hematology, written by specialists for nonspecialists. The book is designed to be easy to use and covers the symptoms, investigations, treatment, and management of conditions presenting in day-to-day practice. In this chapter, the authors review etiology and pathogenesis, diagnosis, recommended investigations, classification, prognosis, and patient care management. The authors note that MDS is primarily a disease of the elderly, with a median age at diagnosis of 60 to 75 years. Treatment ranges from supportive care with blood products, immunotherapy, and chemotherapy, to allogeneic bone marrow transplantation, depending on the age and fitness of the patient and the severity of the myelodysplasia. New drug therapies, including lenalidomide and azacytidine, are in the clinical trial stages of development. The chapter is illustrated with full-color photographs, drawings, and charts. 4 figures. 4 tables. 6 references.
Format:	Book Chapter
Language:	English.
Major Keywords:	Hematologic Diseases. Symptoms. Diagnosis. Patient Care Management. Therapy. Myelodysplastic Syndromes.
Minor Keywords:	Blood Diseases and Disorders. Diagnostic Tests. Risk Factors. Etiology. Prognosis. Drug Therapy. Leukemia. Aged. Cytopenia.
Publication Number:	HEBK10096.
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