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PubMed articles by:
Lee, C.
Hadley, A.
Desilva, K.
Goldstein, D.
World J Surg Oncol. 2009; 7: 8.
Published online 2009 January 21. doi: 10.1186/1477-7819-7-8.
PMCID: PMC2633001
Copyright © 2009 Lee et al; licensee BioMed Central Ltd.
When is a GIST not a GIST? A case report of synchronous metastatic gastrointestinal stromal tumor and fibromatosis
Chee Khoon Lee,corresponding author1 Alison Hadley,2 Keshani Desilva,3 Gareth Smith,4 and David Goldstein1
1Department of Medical Oncology, Prince of Wales Hospital, NSW, Australia
2Department of Medical Oncology, St George Hospital, NSW, Australia
3Department of Anatomical Pathology, Pacific Laboratory Medicine Services, NSW, Australia
4Department of Surgery, Royal North Shore Hospital, NSW, Australia
corresponding authorCorresponding author.
Chee Khoon Lee: cklee1976/at/yahoo.com; Alison Hadley: Alison.Hadley/at/SESIAHS.HEALTH.NSW.GOV.AU; Keshani Desilva: KDesilva/at/nsccahs.health.nsw.gov.au; Gareth Smith: garetts/at/med.usyd.edu.au; David Goldstein: d.goldstein/at/unsw.edu.au
Received October 17, 2008; Accepted January 21, 2009.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background
A number of non-malignant diseases that share similar morphological features as gastrointestinal stromal tumor (GIST) have been reported. Co-existence of GIST with these other diseases is rarely recognized or reported.

Case presentation
We report a case of a 62 year-old man with long-term stable control of metastatic GIST with systemic therapy, presented with an apparent intra-abdominal progression but not supported by imaging with positron emission tomography. Subsequent resection of the intra-abdominal tumor identified a non-malignant fibroid.

Conclusion
Differentiating localized progression of GIST from other diseases has important prognostic and therapeutic implications. The potential for co-existence of non-malignant soft tissue neoplasm should always be considered.

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