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Cancer Intervention and Surveillance Modeling Network

Modeling to guide public health research and priorities

Funding History & Goals

CISNET is funded through an NCI cooperative agreement (U01) mechanism, which ensures substantive NCI involvement in attaining research goals and catalyzing collaborations both between consortium members and with outside groups seeking collaborations.

CISNET I (2000–2005)

CISNET I was funded in two rounds; the first round funded grants on breast, colorectal, and prostate cancers (RFA-CA-99-013), and the second round added lung cancer as well as additional grantees for colorectal and prostate cancers (RFA-CA-02-010). CISNET I provided the support needed to develop applicable mathematical and statistical methodologies and incorporate those methodologies into multi-cohort population models.

During this initial phase, an infrastructure was put into place to facilitate communication among modelers and cross-model comparisons. This discovery phase involved the development of basic mathematical and statistical methodology that is necessary to build multi-cohort population models. Then, during the development phase, these models were validated using available data and applied to the population setting to answer relevant research questions.

CISNET I projects focused on understanding the impact of interventions (e.g., prevention, screening, and treatment) on current population trends in incidence and mortality.

CISNET II (2005–2010)

CISNET II, funded under RFA-CA-05-018, is focused on the application of already developed models to study the population impact of existing or emerging cancer control interventions. CISNET II was an opportunity for new applicants who had working models of one of the CISNET cancer sites to apply for funding to join the CISNET consortium as well as for applicants funded under earlier solicitations to be re-funded. CISNET II also provided the opportunity to establish centers that are dedicated to a specific cancer site for coordinating activities such as joint analyses and synthesis papers, collaborations with outside researchers, and group requests for data resources.

The goal of CISNET II is to promote the application and extension of models to answer vital questions related to emerging cancer trends, the impact of interventions on future trends (development phase), and the identification of optimal strategies for reducing the cancer burden (delivery phase).

CISNET Provides Tools for the Evaluation of the Delivery of Interventions at the Population Level

CISNET and the Challenge of Delivery

CISNET and the Challenge of Delivery. CISNET I goals focused on the discovery-development phases while CISNET II focused on the development-delivery phases.