Press Center
FR Notice - Workshop: Effects of Endocrine Disruptors
[Federal Register: April 3, 1998 (Volume 63, Number 64)]
[Notices]
[Page 16567]
Public Health Service
National Institute of Environmental Health Sciences
Notice of Workshop on "Characterizing the Effects of Endocrine Disruptors on Human Health at Environmental Exposure Levels"
The workshop will be held in the Brownestone Hotel, Raleigh, North Carolina, on May 11-13, 1998, from 9:00am to 5:30pm on May 11th, from 8:30am to 5:30pm on May 12th, and from 8:30am to 12:30pm on May 13th.
Background and Workshop Goals:
Evaluating potential low dose risks of endocrine disruptors
is a major challenge for the risk assessment community. Most important
is how to incorporate mechanistic information that will lead to
biologically based and scientifically credible low-dose extrapolations.
This workshop was organized to provide a forum for discussion
of methods and data needs to improve risk assessments of endocrine
disruptors, with special emphasis on characterizing potential
health effects at low doses (environmental levels). The Workshop
will focus on how to make better use of current knowledge on endocrine
signaling pathways to understand and quantify perturbations induced
by endocrine disrupting agents that lead to adverse health effects
(reproductive and developmental toxicity, neurotoxicity, immunotoxicity,
or cancer) and to specifically address exposures and perturbations
at critical stages of development. Research needs will be identified
within the framework of a risk assessment approach and a final
workshop report to be published in the open scientific literature
will include recommendations and guidance on how to incorporate
mechanistic information into low-dose extrapolations.
Workshop Topics:
- To address the workshop objectives, six breakout group topics
have been identified:
- Homeostasis and endocrine function in adults
- Endocrine function during development
- Species variability, interindividual variability, and tissue specificity
- Dose-response models that link xenobiotic-induced perturbations in endocrine signaling
- pathways with tissue response in adults and during development
- Case study: estimating risk from exposure to DES
- Case study: estimating risk from environmental exposure to PCBs
Invited participants will lead the discussions in each breakout
group. Outside observers from the public sector are welcome with
attendance limited by space available.
Workshop Co-Sponsors:
NIH/National Institute of Environmental Health
Sciences
FDA/National Center for Toxicological Research
US Environmental Protection Agency
Chemical Manufacturers Association.
For further information including observer registration
contact Alma Britton (919-541-0530; fax: 919-541-0295).
Dated: 3/24/98
________________________
Kenneth Olden, Ph.D.
Director
National Institute of Environmental Health Sciences
[Billing Code 4140-01-P]
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