Study # 376

What is the purpose of the study?
To measure the effects of nicotine on brain activity while individuals choose to take nicotine.

Who can participate in the study?
This study is accepting men and women who:

• Are 18 to 50 years of age
• Smoke cigarettes regularly
• Are not actively engaged in or seeking treatment for smoking
• Are in generally good health

What will participants be asked to do?
The study consists of 3 visits.  Participants will:

• Receive nicotine intravenously
• Answer questions about how they think and feel while having an MRI scanner take pictures of their brains during the 2nd and 3rd study sessions
• Provide urine samples during each study visit
• Have blood drawn (optional)
• Abstain from alcohol 24 hours prior to each study visit
• Not drink more than ½ cup of caffeinated beverage for 12 hours prior to each study visit

Where is the study taking place?
The NIDA Intramural Research Program is located on the Johns Hopkins Bayview Medical Center campus in East Baltimore.

How much does it cost?
There is no charge for study-related medical care, including study visits and procedures.

Will I receive payment of some kind?
All study participants will be compensated for their time and travel.

How can I find out if I’m eligible to participate?
Call 1-888-OUR-BRAIN (1-888-687-2724) for a confidential screening.