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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Staff Scientists and Clinicians Wen-Ming Luh, Ph.D.   Dr. Luh is a Staff Scientist of the Functional MRI Facility of the Intramural Research Program, National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. He received his degree from the Medical College of Wisconsin and did his post-doctoral training in Radiology at the University of California at San Diego. Before joining NIH, he was an Applications Development Engineer of the Global MR Engineering of GE Medical Systems. Dr. Luh is the main Physicist for the 2nd 3T MRI scanner. He oversees the daily operation of the 2nd 3T scanner and provides technical assistance and development for 3T user community. Research Interests Dr. Luh�s main research focuses on functional contrast mechanism using perfusion-based MRI techniques, especially with arterial spin labeling methods to measure changes in cerebral blood flow non-invasively. Dr. Luh has shown that the activated tissue in the brain identified with arterial spin labeling methods is primarily gray matter whereas using conventional functional MRI contrast, blood oxygenation level dependent contrast, it is more localized to cerebrospinal fluid. Recent development involves technical advances in increasing spatial resolution and signal-to-noise ratio to better characterize the tissue components contributing to activation in functional MRI. Representative Selected Recent Publications: Miller KL, Luh WM, Liu TT, Martinez A, Obata T, Wong EC, Frank LR, Buxton RB: Characterizing the perfusion response to stimuli of short duration. Human Brain Mapping, 13: 1-12, 2001. Wong EC, Liu TT, Luh WM, Frank LR, Buxton RB: A T1 and T2 Selective Method for Improved SNR in CSF Attenuated Imaging: T2-FLAIR. Magn. Reson. Med., 45: 529-532, 2001. Wong EC, Luh WM, Liu TT: Turbo ASL: arterial spin labeling with higher SNR and temporal resolution. Magn. Reson. Med., 44: 511-515, 2000. Luh WM, Wong EC, Bandettini PA, Ward BD, Hyde JS: Comparison of simultaneously measured perfusion and BOLD signals increases during brain activation with T1-based tissue identification. Magn. Reson. Med., 44: 137-143, 2000. Luh WM, Wong EC, Bandettini PA, Hyde JS: QUIPSS II with thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling. Magn. Reson. Med, 41: 1246-1254, 1999. Address:   Phone:   Email: Fax:   Lab Web Site:       Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.