| | Staff Scientists and Clinicians
| Jingshan Chen, M.D., Ph.D. |
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Dr.
Chen is a staff scientist at the Clinical
Brain Disorders Branch of the Intramural Research
Program, National Institute of Mental Health, National
Institutes of Health in Bethesda, Maryland. He attended
medical school at The Second Military Medical School in
Shanghai, China and graduate school at Fordham University
in New York, USA. He received postdoctoral training at
Albert Einstein Medical College and Yale University School
of Medicine. He was an assistant professor in Department
of Psychiatry and director of Transgenic Facility in Division
of Molecular Psychiatry at Yale University Medical School. |
| Research Interests |
| Dr.
Chen is interested in molecular mechanisms of pathogenesis
of schizophrenia. He applies inducible transgenic technology
and knockout technology to the development of genetic
animal models carrying human mutations, especially functional
SNP mutations. He has developed inducible transgenic mice
carrying human COMT-Met and –Val alleles, and Met-
and Val- BDNF-EGFP genes. He also introduced human single
nucleotide polymorphism (SNP) mutations into mouse COMT
gene, and analyzed the effect of the SNP mutations on
COMT enzyme activity and developed COMT knock-in mutant
constructs. The animal models will be used for testing
the effect of the functional SNP mutations within schizophrenia
risk genes on cognitive and sensory gating functions.
These studies could provide insight into the molecular
mechanisms of cognitive dysfunction in schizophrenia,
generate new animal models for testing novel antipsychotic
drugs for the treatment of negative symptoms, and validate
functional SNPs for future predictive and individualized
medicine. |
| Representative Selected Recent Publications: |
- Chen, J., G. Preston, J.M. Pickel, B.S. Kolachana, J.W. Nagle, M.F. Egan, D.R. Weinberger: Development of inducible transgenic mice carrying human catechol - o - methyltransferase val and met alleles. Abstracts of 32th Annual Meeting of Society for Neuroscience, 344.16.
- Nakagawa S, Kim JE, Lee R, Chen J, Fujioka T, Malberg J, Tsuji S, Duman RS.: Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus. J Neurosci. 22(22):9868-76.
- Chen, J.: Dopamine D2 receptor and obesity. The Lancet 357:1883.
- Chen, J., Y.J. Zhang, M.B. Max, C. Steffen, E.S. Ang, L. Zeng and E.J. Nestler. Regulation of cyclin-dependent kinase 5 (cdk5) in hippocampus by chronic electroconvulsive seizure: role of ãFosB. J. Neurosci., 20; 8965-8971.
- Kelz, M.B., J. Chen, W.A. Carlezon Jr, K. Whisler, L. Gilden, C. Steffan, Y.J. Zhang, L. Marotti, D.W. Self, T. Tkatch, G. Baranauskas, J.D. Surmeier, R.L. Neve, R.S. Duman, M.R. Picciotto and E.J. Nestler: Expression of the transcription factor �FosB controls sensitivity to cocaine.Nature 401; 272-276.
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