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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Principal Investigators Judith L. Rapoport, M.D.   Judith L. Rapoport M.D. is Chief of the Child Psychiatry Branch NIMH. She is a Graduate of Harvard Medical School. She did her clinical and research training at the Massachusetts Mental Health Center (Boston), Children's Hospital (DC), and the Karolinska Hospital (Stockholm). Her research has focused on diagnosis in child psychiatry, Attention Deficit Hyperactivity Disorder and Obsessive Compulsive Disorder. Over the past decade, her group has been studying the clinical phenomenology, neurobiology and treatment of Childhood Onset Schizophrenia. She is an author or coauthor of over 300 scientific papers, a member of the Institute of Medicine, and a Fellow of the American Academy of Arts and Sciences. Research Interests Psychiatric Diagnosis; Hyperactive Children; Biological Aspects of Child Psychiatry; Pediatric Psychopharmacology; Obsessive Compulsive Disorder; Childhood Psychoses Representative Selected Recent Publications: Rapoport JL, Giedd JN, Blumenthal J, Hamburger S, Jeffries N, Fernandez T, Nicolson R, Bedwell J, Lenane M, Zijdenbos A, Paus T, Evans A: Progressive cortical change during adolescence in childhood onset schizophrenia: A longitudinal MRI study. Arch Gen Psychiatry, 56:649-654, 1999. Nicolson R, Rapoport JL: Childhood onset schizophrenia: Rare but worth studying. Biol Psychiatry, 46, 1418-1428, 1999. Thompson PM, Vidal C, Giedd JN, Gochman P, Blumenthal J, Nicolson R, Toga AW, Rapoport JL: Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia. PNAS, 98:20, 11650-11655, 2001. Castellanos FX, Lee PP, Sharp, W, Jeffries NO, Greenstein, DK, Clasen LS, Blumenthal JD, James RS, Ebens CL, Walter JM, Zijdenbos A, Evans AC, Giedd JN, Rapoport JL: Developmental Trajectories of Brain Volume Abnormalities in Attention-Deficit/Hyperactivity Disorder. JAMA, 288:1740-1748, 2002. Liu H, Heath SC, Sobin C, Roos JL, Galke BL, Blundell ML, Lenane M, Robertson B, Wijsman EM, Rapoport JL, Gogos JA, Karayiorgou M: Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. PNAS, 99(6) 3717-3722, 2002. Address: Child Psychiatry Branch National Institute of Mental Health 10 Center Drive Building 10, Room 3N202 Bethesda, MD 20892-1600 Phone: (301) 496-6080, 1-888-254-3823 Email Dr. Rapoport Fax: (301) 402-0296 Lab Web Site: http://intramural.nimh.nih.gov/chp/index.html     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.