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Chromosome Aberrations: Dicentric Chromosomes - Illustration

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- Significant exposure to radiation will result in disruption of chromosomes
- Increasing exposure dose will produce increasing numbers of abnormal chromosomes
- Techniques have been described for measuring the number of dicentric chromosomes in peripheral blood lymphocytes
- The number of dicentric chromosomes is correlated with and can be used to estimate exposure dose
- Counting the number of dicentric chromosomes is part of clinical biodosimetry, but it is time consuming and highly technique dependent.
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