| | Principal Investigators
| Jay Giedd,
M.D |
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Dr.
Giedd received his MD from the University of North Dakota
in 1986. He received his training in adult psychiatry
at the Menninger Foundation in Topeka, KS, and his Child
and Adolescent Psychiatry training at Duke University
in Durham, NC. He is board certified in General, Child
and Adolescent, and Geriatric Psychiatry. Currently,
he is the Chief of the Unit
on Brain Imaging in the Child Psychiatry Branch at the NIMH. His research focuses on the biological
basis of cognitive, emotional and behavioral disorders. |
| Research Interests |
| Dr. Giedd's research team at the Child Psychiatry Branch of the National Institute of Mental Health seeks to use cutting edge technologies to explore the relationship between genes, brain, and behavior in healthy development and in neuropsychiatric disorders of childhood onset. They are conducting longitudinal neuropsychological and brain imaging studies of healthy twins and singletons as well as clinical groups such as Attention-Deficit/Hyperactivity Disorder, Childhood-Onset Schizophrenia, and others. Over the past 10 years they have acquired over 3000 MRI scans making this the largest pediatric neuroimaging project of its kind. The lab also studies sexual dimorphism in the developing brain, especially important in child psychiatry where nearly all disorders have different ages of onsets, prevalence, and symptomatology between boys and girls, by exploring clinical populations which have unusual levels of hormones (e.g. Congenital Adrenal Hyperplasia, Familial Precocious Puberty) or variations in the sex chromosomes (e.g. Klinefelter's Syndrome, XYY, XXYY). The lab is also conducting studies of monozygotic and dizygotic twins which are beginning to unravel the relative contributions of genes and environment on a variety of developmental trajectories in the pediatric brain. The group is also involved in the development and application of techniques to analyze brain images and is actively collaborating with other imaging centers throughout the world to advance the image analysis field.
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| Representative Selected Recent Publications: |
- Vidal CN, Rapoport JL, Hayashi KM, Geaga JA, Sui Y, McLemore LE, Alaghband Y, Giedd JN, Gochman P, Blumenthal J, Gogtay N, Nicholson R, Toga AW, Thompson PM: Dynamically spreading frontal and cingulate deficits mapped in adolescents with schizophrenia.
Archives of General Psychiatry, 63: 25-34, 2006.
- Rose AB, Merke DP, Clasen LS, Rosenthal MA, Wallace GL, Vaituzis AC, Fields JD, Giedd JN:
Effects of hormones and sex chromosomes on stress-influenced regions of the developing pediatric brain.
Annals of the New York Academy of Sciences, 1032: 231-233, 2004. (View PDF)
- Shen D, Liu D, Liu H, Clasen L, Giedd J, Davatzikos C:
Automated morphometric study of brain variation in XXY males.
NeuroImage, 23: 648-53, 2004. (View PDF)
- Saluja G, Iachan R, Scheidt PC, Overpeck MD, Sun W, Giedd JN:
Prevalence of and risk factors for depressive symptoms among young adolescents. Archives of Pediatric & Adolescent Medicine, 158: 760-5, 2004. (View PDF)
- Giedd JN:
Structural magnetic resonance imaging of the adolescent brain. Annals of the New York Academy of Science, 1021: 77-85, 2004. (View PDF)
- Gogtay N, Giedd JN, Lusk L, Hayashi KM, Greenstein D, Vaituzis AC, Nugent TF 3rd, Herman DH, Clasen LS, Toga AW, Rapoport JL, Thompson PM:
Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences USA, 101: 8174-8179, 2004. (View PDF)
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