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Ongoing Collaborations: Cancer Intervention and Surveillance Modeling Network (CISNET)

The Cancer Intervention and Surveillance Modeling Network (CISNET) is a consortium of NCI-sponsored investigators who focus on using modeling to improve our understanding of the impact of cancer control interventions (e.g., prevention, screening treatment) on population trends in incidence and mortality. These models are also used to project future trends, and to help determine optimal cancer control strategies.

The BCSC has contributed data to the Breast Base Case, a working group of CISNET, to address the impact of mammography and adjuvant therapy on trends in breast cancer mortality from 1975-2000. The purpose of this modeling effort is to partition observed mortality trends into components associated with the increased use of adjuvant therapy, mammography, and background changes in underlying risk. Certainly the current debate surrounding mammography has made this a timely topic, especially as investigators attempt to weigh any mortality gains against its downsides, such as overdiagnosis and false positives.

The Breast Base Case simulations will form the basis of a special Journal of the National Cancer Institute Monograph on the subject. The monograph will include a description of each model, as well as a synthesis of results from the simulations, depicting model differences and similarities over the results.

CISNET Publications Using BCSC data

Cronin KA, Yu B, Krapcho M, Miglioretti DL, Fay MP, Izmirlian G, Ballard-Barbash R, Geller BM, Feuer EJ. Modeling the dissemination of mammography in the United States. Cancer Causes Control 2005 16(6):701-712.

Berry DA, Cronin KA, Plevritis SK, Fryback DG, Clarke L, Zelen M, Mandelblatt JS, Yakovlev AY, Habbema JD, Feuer EJ; Cancer Intervention and Surveillance Modeling Network (CISNET) Collaborators. Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med 2005 Oct 27;353(17):1784-92.

Full list of CISNET publications

National Cancer Institute Department of Health and Human Services National Institutes of Health The US government's official web portal Maintained by the Applied Research Program,
Division of Cancer Control and Population Sciences