Protocol Number: 92-EI-0113

Title:

Immunopathology and Molecular Pathology of Ocular Diseases in Humans

Number:

92-EI-0113

Summary:

The purpose of this study is to better understand the processes involved in the development of various eye conditions, such as uveitis, disorders of the conjunctiva, cornea, vitreous and retina, metabolic or genetic eye diseases or eye tumors, in order to develop better methods of diagnosis and treatment.

Patients who require eye surgery to treat an eye disease or other disease in which the eye is involved may participate in this study. Samples of eye tissue and fluid that are normally removed and discarded during eye surgery will instead be given to researchers for study. The tissues will be examined under microscope and studied using sophisticated chemical and biological tests. Immune cells from blood samples may also be examined. These studies will help better understand and diagnose the various eye diseases and to develop more attractive therapies.

Sponsoring Institute:

National Eye Institute (NEI)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

1. Participants must be undergoing an eye procedure for clinical care of their condition which requires the removal of tissue specimens or have agreed pre-mortem to donate their eyes after death for research purposes.

2. Participants must agree to the de-identified storage of their sample for potential use in future research projects.

3. For conditions where blood is needed for analysis, participants must consent to having blood drawn for research evaluation, and be able to safely give a blood sample.

4. Participants must be able to give informed consent for themselves and/or their minor children who wish to enroll.

EXCLUSION CRITERIA:

1. Participant is unwilling or unable to give informed consent.

Special Instructions:

Currently Not Provided

Keywords:

Ocular Pathology

Ocular Immunology

Clinicopathological Correlation

Immunohistochemical Methods

In Situ Hybridization

Polymerase Chain Reaction

Microdissection

Recruitment Keyword(s):

Ocular Disease

Condition(s):

Conjunctival Disease

Corneal Disease

Eye Disease

Uveitis

Vitreoretinopathy, Proliferative

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Eye Institute

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Molecular pathology of primary intraocular lymphoma. Chan CC. Trans Am Ophthalmol Soc. 2003;101:275-92.

Molecular pathology of age-related macular degeneration. Ding X, Patel M, Chan CC. Prog Retin Eye Res. 2008 Nov 6.

Immunopathology of uveitis. Chan CC, Li Q. Br J Ophthalmol. 1998 Jan;82(1):91-6.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Clinical Research Informatics, CC.

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