Cancer Genetics Network (CGN)

Description:
The Cancer Genetics Network (CGN) is a resource for investigators conducting research on the genetic basis of human cancer susceptibility; integration of this information into medical practice; and behavioral, ethical, and public health issues associated with human genetics. The CGN can provide a wide variety of research services and specialized expertise to assist investigators with approved studies. Prospective investigators can freely query the CGN core database to learn more about the aggregate characteristics of participants and discover how the CGN may be used for research purposes.

A core dataset is available on each participant and contains information on sociodemographic characteristics, history of cancer and/or premalignant conditions, cancer-relevant surgeries, four-generation cancer family pedigree, history of tobacco use, and expressed interest in genetic counseling. Data also are available on some participants who enrolled in special studies, such as on cancer-related outcomes, screening, counseling, and attitudes. Limited biospecimens include DNA samples from participants with early onset cancer, multiple cancers, and prostate cancer; and longitudinal blood samples on participants in ovarian and breast cancer studies.

Web Site:
Epidemiology and Genetics Research Program http://epi.grants.cancer.gov/CGN/


Availability:
From early in the research planning process, the CGN team can advise investigators on study design and the availability of participants. The team also can provide expertise in biostatistics, statistical genetics, epidemiology,genetic epidemiology, and behavioral research. The Data Coordinating Center can assist with study preparation, database management, logistics, and communications across participating sites to help ensure the success and smooth operation of research projects.

For approved studies, the following CGN services are available for a fee:

• Guidance on developing concept proposals to use CGN resources
• Assistance in the conduct of CGN-approved studies: advice on designing studies to maximize use of CGN resources; assistance in developing new enrollment and data collection protocols and forms; support in developing study protocols and required ancillary documents; assistance in writing Institutional Review Board protocols
• Collection and storage of biospecimens (fresh tissue, RNA, and DNA)
• Informatics services: software development, including computerized followup for study participants and constructing databases with study questionnaires and surveys; data management with a specially adapted version of TrialDB. (TrialDB is a customizable Web-based clinical trials database system that can be used for storing and querying CGN epidemiologic data.)

Cost:
Investigators are expected to develop their own research funding in consultation with CGN.

Contact:
Dr. Carol Kasten, 301-402-8212; kastenca@mail.nih.gov
Barbara Guest, 301-435-4913; guestb@mail.nih.gov
Scott Rogers, 301-594-7346; rogerssc@mail.nih.gov

This page last updated 2008-12-03 17:07:57