Nominations to the Testing Program
Nominations in Review 2008
* Note: The terms "initial toxicological characterization" and "comprehensive toxicological characterization" in this table refer to the approximate scope of a research program to address toxicological data needs. The types of toxicological studies that would be considered by NTP staff during the conceptualization and design of a research program for each are:
-Initial toxicological characterization: biomolecular screening, in vitro mechanistic, in vitro and in vivo genotoxicity, absorption, disposition, metabolism, and elimination, and short-term repeat dose (2-4 weeks) in vivo studies
-Comprehensive toxicological characterization: all of the aforementioned plus subchronic toxicity (13-26 weeks), chronic toxicity (1-2 years), carcinogenicity in conventional or genetically modified rodent models, organ systems toxicity (immunotoxicity, reproductive and developmental toxicity, neurotoxicity), in vivo mechanistic, toxicokinetics, and other special studies as appropriate (e.g. chemistry, toxicogenomics, phototoxicity).
See here for further Description of NTP Study Types.
For information, questions or comments, contact:
Dr. Scott A. Masten
Director, Office of Nomination and Selection
National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)
[ Send Email ]
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Dimorpholinodiethyl ether [6425-39-4] |
National Cancer Institute |
High production volume; potential worker exposures; lack of adequate toxicological data; suspicion of toxicity based on structure |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
2-Ethylhexylp-methoxycinnamate [5466-77-3] |
National Cancer Institute |
High production volume; widespread consumer exposure as a common sunscreen active ingredient; reported estrogenic and reproductive effects |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
4,7,10-Trioxatridecane- 1,13-diamine [4246-51-9] |
National Cancer Institute |
High production volume; potential worker exposures; lack of adequate toxicological data; acutely toxic |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Vanadium, tetravalent and pentavalent forms |
National Institute of Environmental Health Sciences U.S. Environmental Protection Agency |
Widespread occurrence as drinking water contaminant and use as a dietary supplement; EPA Drinking Water Contaminant Candidate List research need; pentavalent form carcinogenic via inhalation route; inadequate data to assess risk of oral exposures |
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Web page last updated on September 04, 2008