Protocol Number: 08-I-0034

Title:

Validation of (1)H-Magnetic Resonance Spectroscopy for Quantification of Hepatic Triglyceride Content

Number:

08-I-0034

Summary:

This study will determine whether a magnetic resonance imaging (MRI) test of the liver can accurately measure the amount of fat in the liver compared to the results of a liver biopsy.

People 18 years of age and older who are scheduled to have or who have already had a liver biopsy as part of their medical care within 1 month of enrollment in this study may be eligible to participate.

Participants undergo an MRI. For this procedure, the subject lies still on a table that slides into a narrow metal cylinder (the MRI scanner) for 30 to 60 minutes. A special pad or tube is placed around the abdomen to improve the image of the liver obtained. Earplugs are placed in the ears to muffle loud thumping and knocking sounds that occur with the electrical switching of the magnetic field. The findings of the MRI are compared with those of the liver biopsy.

Sponsoring Institute:

National Institute of Allergy and Infectious Diseases (NIAID)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

Age 18+, male or female

Planned liver biopsy or liver biopsy within the past month with pathology samples available to be read at NIH CC

EXCLUSION CRITERIA:

Known current pregnancy or pregnancy within 6 months

Contraindications to MRI

Subject is deemed unable to comply with requirements of study participation

Special Instructions:

Currently Not Provided

Keywords:

1H-Magnetic Resonance Spectroscopy

Hepatic Steatosis

Liver Fat

Liver Biopsy

Liver

Recruitment Keyword(s):

Hepatitis

Fatty Liver

Liver Biopsy

Condition(s):

Fatty Liver

Hepatitis

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

Procedure/Surgery: Diagnostic Radiology: 1H-MRS of the liver

Supporting Site:

National Institute of Allergy and Infectious Diseases

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Nakao K, Nakata K, Ohtsubo N, Maeda M, Moriuchi T, Ichikawa T, Hamasaki K, Kato Y, Eguchi K, Yukawa K, Ishii N. Association Between Nonalcoholic Fatty Liver, Markers of Obesity, and Serum Leptin Level in Young Adults. Am J Gastroenterol. 2002 Jul;97(7):1796-801.

Banerji MA, Buckley MC, Chaiken RL, Gordon D, Lebovitz HE, Kral JG. Liver Fat, Serum Triglycerides and Visceral Adipose Tissue in Insulin-Sensitive and Insulin-Resistant Black Men with NIDDM. Int J Obes Relat Metab Disord. 1995 Dec;19(12):846-50.

Sabir N, Sermez Y, Kazil S, Zencir M. Correlation of Abdominal Fat Accumulation and Liver Steatosis: Importance of Ultrasonographic and Anthropometric Measurements. Eur J Ultrasound. 2001 Dec;14(2-3):121-8.

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