Protocol Number: 06-DC-0218

Title:

Neural Modeling and Brain Imaging of Tinnitus

Number:

06-DC-0218

Summary:

This study will use magnetic resonance imaging (MRI) to compare brain function in three groups of people: hearing-impaired people with tinnitus; hearing-impaired people without tinnitus; and people with normal hearing and without tinnitus. Also known as "ringing in the ears," tinnitus is the false sensation of sounds.

Adults between 30 and 65 years of age who meet the following criteria may be eligible for this study:

-Mild to moderate hearing loss who have experienced tinnitus daily for at least 1 year

-Mild to moderate hearing loss who have never or rarely experienced tinnitus

-Normal hearing who have never or rarely experienced tinnitus

Candidates are screened with a medical history and questionnaires.

Participants have a detailed hearing test to measure hearing and the nature of tinnitus. In a second visit, subjects have a brief physical examination, followed by MRI scanning. MRI uses a magnetic field and radio waves to produce images of body tissues and organs. For this procedure, the subject lies on a table that can slide in and out of the scanner (a narrow cylinder), wearing earplugs to muffle loud knocking and thumping sounds that occur during the scanning process. The subject may be asked to lie still for up to 8 minutes at a time. During the MRI, the subject performs computer-based tasks that involve listening to sounds. Another hearing test is done after the MRI.

Sponsoring Institute:

National Institute on Deafness and Other Communication Disorders (NIDCD)

Recruitment Detail

Type: No longer recruiting/follow-up only

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Email address for study:

tinnitus@mail.nih.gov

Keyword(s):

Functional Magnetic Resonance Imaging (fMRI)

Tinnitus

Hearing Impairment

Hearing Loss

Auditory Processing

Recruitment Keyword(s):

Tinnitis

Hearing Loss

Condition(s):

Tinnitus

Hearing Loss

Investigational Drug(s):

None

Investigational Device(s):

None

Interventions:

None

Supporting Site:

National Institute on Deafness and Other Communication Disorders

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Mirz F, Gjedde A, Sodkilde-Jrgensen H, Pedersen CB. Functional brain imaging of tinnitus-like perception induced by aversive auditory stimuli. Neuroreport. 2000 Feb 28;11(3):633-7.

Giraud AL, Chery-Croze S, Fischer G, Fischer C, Vighetto A, Gregoire MC, Lavenne F, Collet L. A selective imaging of tinnitus. Neuroreport. 1999 Jan 18;10(1):1-5.

Mirz F, Gjedde A, Ishizu K, Pedersen CB. Cortical networks subserving the perception of tinnitus--a PET study. Acta Otolaryngol Suppl. 2000;543:241-3.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department Clinical Research Informatics, CC.

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