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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Staff Scientists and Clinicians Frank Ye, Ph.D.   Dr. Frank Ye is an MRI physicist in the Functional MRI Facility of the intramural research division in NIMH. Dr. Ye attended Beijing University and obtained his B.Sc. and M.Sc. degrees there. He studied in University of Alberta and obtained his Ph.D. in biomedical engineering in 1995. Dr. Ye did his postdoctoral research in the Brain Disorders Branch in NIMH before he joined the Functional MRI Facility in 2001 as a staff scientist. Research Interests Dr. Ye�s primary responsibility is to provide instrumental and technical support in the fMRI study of non-human primates on the newly purchased 4.7-Tesla vertical-bore MR monkey scanner. His expertise is in MRI pulse sequence programming and experimental parameter optimization in fMRI protocols. His own research interests have been in developing MRI techniques for reliable and accurate CBF measurement, and in using combined perfusion and BOLD measurement to elucidate the physical and physiological mechanisms underlying in-vivo fMRI techniques. Representative Selected Recent Publications: F. Q. Ye, V. S. Mattay, P. Jezzard, J. A. Frank, D. R. Weinberger and A. C. McLaughlin : Correction for vascular artifacts in cerebral blood flow values measured using arterial spin tagging techniques. Magn. Reson. Med. 37: 226-235, 1997. F. Q. Ye, K. Faith Berman, T. Ellmore, G. Esposito, J. D. van Horn, Y. Yang, J. Duyn, A. M. Smith, J. A. Frank, D. R. Weinberger, A. C. McLaughlin: H2 15O PET validation of steady-state arterial spin tagging cerebral blood flow measurements in humans. Magn. Reson. Med. 44:450-456, 2000. F. Q. Ye, J. A. Frank, D. R. Weinberger, A. C. McLaughlin: Noise reduction in 3D perfusion imaging by attenuating the static signal in arterial spin tagging (ASSIST). Magn. Reson. Med., 44:92-100, 2000. F. Q. Ye, A. M. Smith, V. S. Mattay, U. Ruttiman, J. A. Frank, D. R. Weinberger, A. C. McLaughlin : Quantitation of regional cerebral blood flow increase in the prefrontal cortex during a working memory task: a steady-state arterial spin tagging study. NeuroImage, 8: 44-49, 1998. K. S. St Lawrence, F. Q. Ye, B. K. Lewis, D. R. Weinberger, J. A. Frank, A. C. McLaughlin: Effects of indomethacin on cerebral blood flow at rest and during hypercapnia: an arterial spin tagging study in humans. J. Magn. Reson. Imaging 15:628-635, 2002. Address:   Phone:   Email:   Fax:   Lab Web Site: http://fim.nimh.nih.gov/     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.