| | Staff Scientists and Clinicians
| Monique Ernst, M.D., Ph.D. |
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Dr.
Ernst is a Staff Clinician in the Section
of Developmental and Affective Neuroscience (SDAN) of
the Mood and Anxiety Disorders Program (MAP) Branch
of the Intramural Research Program, National Institute
of Mental Health, National Institutes of Health in Bethesda,
Maryland. She completed medical school at the Pitie Salpetriere
University in Paris, France, and the Ph.D. program in
Neurophysiology; Nervous System and Behavior of the Jussieu
University of Paris VI. She did residencies in adult psychiatry
at Beth Israel Medical Center and in child psychiatry
at Bellevue Hospital & New York Medical Center in
New York. She is certified by the American Board of Psychiatry
and Neurology in Psychiatry and by the American Board
of Psychiatry and Neurology in Child and Adolescent Psychiatry.
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| Research Interests |
Dr.
Ernst’s research has focused on brain mechanisms
involved in risk factors, pathogenesis, and treatment
of pediatric neuropsychiatric disorders. Before joining
NIMH in March 2001, her work was centered on children
with autism, Lesch-Nyhan Disease, attention-deficit/hyperactivity
disorder and substance abuse problems. As part of the
Section of Developmental and Affective Neuroscience, she
is now building a research program to examine in children
genetic vulnerabilities for mood and anxiety disorders,
and to map deficits in reward-related behaviors which
play a role in mood disorders.
Her work is noted for studies of functional neuroimaging
in children aimed at clarifying dopaminergic deficits
in disorders involving dopamine abnormalities. She lately
concentrated her work on reward-related mechanisms, using
both positron emission tomography and functional magnetic
resonance imaging. |
| Representative Selected Recent Publications: |
- Ernst M, Grant SJ, London ED, Contoreggi CS, Kimes AS, Spurgeon L.: Decision-Making in Behavior Disordered Adolescents and Adult Substance Abusers Am J Psychiatry (in press).
- Ernst M, Bolla K, Mouratidis M, Contoreggi C, Matochik JA, Kurian V, Cadet J-L, Kimes AS, London ED.: Decision-making in a risk-taking task: a PET study. Neuropsychopharmacology 26, (5) 683-691. 2002.
- Ernst M, Zametkin AJ, Matochik JA, Jons PH, and Cohen RM.: Presynaptic Dopaminergic Activity in ADHD Adults. A [Fluorine-18]Fluorodopa Positron Emission Tomographic Study. J Neuroscience, 18 (15): 5901-5907, 1998.
- Ernst M, Zametkin AJ, Matochik JA, Pascualvaca D, Jons, P, Cohen RM: High midbrain DOPA decarboxylase activity in children with ADHD, Am J Psychiatry 156:1209-1215, 1999.
- Ernst M, Zametkin AJ, Matochik JA, Pascualvaca D, Cohen RM. : Low medial prefrontal dopaminergic activity in autistic children. The Lancet, 350:638, 1997.
- Ernst M., Zametkin A.J., Matochik J.A., Pascualvaca D., Jons P.H., Hardy K., Hankerson J.G., Doudet D.D., Cohen R.M.:(1996) Presynaptic dopaminergic deficits in Lesch-Nyhan Disease. New England Journal of Medicine, 334:1568-1604. 1996.
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