| | Staff Scientists and Clinicians
| Jing Du, M.D., Ph.D. |
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Jing
Du, MD PhD is a staff scientist in the Laboratory
of Molecular Pathophysiology of the Mood and Anxiety Program
at the National Institute of Mental Health. Dr. Du received her M.D. from Beijing University,
Health Science Center in 1986 and her Ph.D. from Rutgers University & UMDNJ Medical School in 1992. Dr. Du
was trained as a postdoctoral fellow in the Laboratory of Cell and Molecular Neurophysiology with Dr. Chris J.
McBain at the National Institute of Child and Human Development. In 1997, Dr. Du worked in the Laboratory of Cellular and Synaptic Neurophysiology as a Research Fellow under the advisement of Dr. Bai Lu, conducting research on activity-dependent regulation of brain-derived neurotrophic factor (BDNF) receptor TrkB insertion and internalization. In 2001, Dr. Du joined Laboratory of Molecular Pathophysiology as a staff scientist. Dr. Du has published 38 peer-reviewed research articles in the scientific journals, including Proceedings of the National Academy of Sciences (PNAS), Journal of Neuroscience, Journal of Cell Biology and so on. For her dedicative work and contributions, Dr. Du has received awards and honors, including ACNP/Sanofi-Aventis Pharmaceutical Travel Award, NIH Performance Award (2003, 2005, 2006), FARE award, and the ASCB Travel award.
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| Research Interests |
| Dr. Du currently focuses her research on the cellular and molecular mechanisms in the pathophysiology and treatment of mood disorders. Specifically, she is involved in: 1) elucidation of the molecular mechanisms of genes associated with bipolar disorder (e.g. GluR1, GSK-3β, Bcl-2, etc.), using behavioral animal models; 2) investigation of disease- and treatment-induced changes on synaptic plasticity and mitochondrial functions; 3) development of innovative treatment based on elucidating the molecular and cellular mechanisms |
| Representative Selected Recent Publications: |
- Jing Du, Yun Wang, Richard Hunter, Yanling Wei, Rayah Blumenthal, Cynthia Falke, Rushaniya Kairova, Rodrigo Machado-Vieira, Bruce McEwen and Husseini K. Manji:Dynamic Regulation of Mitochondrial Function by Glucocorticoids. Proceeding of National Academy of Sciences (PNAS), In press. 2009
- Jing Du, Thomas Creson, Neil Gray, Cynthia Falke, Yanling Wei, Yun Wang, Rayah Blumenthal, Guang Chen and Husseini K. Manji: The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. Journal of Neuroscience, 28(1):68-79, 2008. (NIMH Science News)
- Steven T. Szabo, Rodrigo Marchado-Vieira, Peixiong Yuan, Yun Wang, Yanling Wei, Cynthia Falke, Chiara Cirelli, Giulio Tononi, Husseini Manji, Jing Du*: Glutamate receptors as targets of protein kinase C in the treatment of mania in animal models. Neuropharmacology, Epub. August, 2008. (*corresponding author)
- Jing Du, Suzuki Katsuji, Yanling Wei, Zheng Chen, Cynthia Falke, Carlos Zarate and Husseini K. Manji: The anticonvulsants lamotrigine, riluzole and valproate differentially regulate AMPA receptor trafficking: relationship to clinical effects in mood disorders. Neuropsychopharmacology, 32(4):793-802, 2007.
- Jing Du, Neil Gray, Cynthia Falke, Wenxin Chen, Steve Szabo, Peixiong Yuan, and Husseini K. Manji: Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit GluR1. Journal of Neuroscience, 24:6578-6589. 2004.
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