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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Staff Scientists and Clinicians Joseph H. Callicott, M.D.   Dr. Callicott is Chief of the Unit on Functional MRI within Clinical Brain Disorders Branch of the Intramural Research Program, National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. He attended the College of William and Mary and the University of Virginia School of Medicine and completed psychiatry residency at the University of Virginia and the NIMH. He is board certified in psychiatry. Dr. Callicott is the recipient of a NARSAD Young Investigator Award, the Society of Biological Psychiatry Lilly Fellowship Award, and the APA Kempf Fund Award for Research Development in Psychobiological Psychiatry. Research Interests Dr. Callicott’s research is focused on fMRI of working memory in patients and controls. In particular, Dr. Callicott has raised the issue of prefrontal cortical neuronal inefficiency as a primary deficit in schizophrenia. fMRI data in healthy subjects, patients, and their unaffected siblings is currently used as an intermediate phenotype in clinical genetic studies in the Clinical Brain Disorders Branch. Representative Selected Recent Publications: Callicott JH, Bertolino A, Mattay VS, Langheim FJ, Duyn J, Coppola R, Goldberg TE, Weinberger DR: Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia: revisited. Cereb Cortex, 10(11):1078-1092, 2000. Callicott JH, Bertolino A, Egan MF, Mattay VS, Langheim FJ, Weinberger DR.: Selective relationship between prefrontal N-acetylaspartate measures and negative symptoms in schizophrenia. Am J Psychiatry, 157(10):1646-1651, 2000. Callicott JH, Egan MF, Mattay VS, Bertolino A, Bone A, Verchinski BA, Weinberger DR.: Physiological dysfunction of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psych [in press]. Egan MF, Goldberg TE, Kolachana B, Callicott JH, Mazzanti CM, Straub R, Goldman D, Weinberger DR:. Effect of COMT Val108/158Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA, 98(12):6917-6922, 200`. Egan MF, Callicott JH*, Kojima M*, Goldberg TE*, Kolachana BF, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell [in press]. *(These authors contributed equally). Address: Joseph H. Callicott, M.D. Chief, Unit on Cognition and Psychosis Program 10 Center Drive Room 4C-216, MSC 1364 Bethesda, MD 20892-1364 Phone: 301-402-3081 Email Dr. Callicott Fax: 301-451-5148 Lab Web Site: http://cbdb.nimh.nih.gov/     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.