Protocol Number: 07-C-0123
-Research suggests that breast cancers may arise from a population of stem cells in the normal mammary gland that produce clones of cancer cells. -Researchers are now trying to determine what events may initiate the formation of cancer cells. Objectives: -To look for and describe breast stem cells from normal breast tissue from women who do not have breast cancer. -To compare the breast stem cells between women at increased risk for breast cancer and women at average risk for breast cancer. -To show a relationship between the number and type of breast stem cells with the density (appearance) of the mammogram (breast x-ray). -To make cell cultures (grow cells under controlled conditions) from the breast stem cells. Eligibility: -Women 18 years of age and older who are at average or increased risk for breast cancer. Design: Participants complete a health history questionnaire, family history questionnaire and risk assessment questionnaire. -Participants have a mammogram and breast biopsy (surgical removal of a sample of breast tissue). -Women who can become pregnant have a urine pregnancy test.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/30/2009
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