Protocol Number: 99-HG-0056

Title:

Pulmonary Fibrosis Associated with Rheumatoid Arthritis: Definition of the Natural History of Disease

Number:

99-HG-0056

Summary:

Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA). The cause of the pulmonary fibrosis in patients with RA is unknown.

Patients participating in this study will undergo a series of tests and examinations before and throughout the study. The tests include blood and urine tests, electrical measures of heart function (ECG), chest x-rays, CAT scans, nuclear medicine scans, breathing tests, exercise tests, and fiberoptic bronchoscopy.

The goals of this study are to:

1. Estimate how common pulmonary fibrosis is in patients with rheumatoid arthritis,

2. Describe the natural course of pulmonary fibrosis in patients with rheumatoid arthritis,

3. Estimate the survival rate of patients with pulmonary fibrosis and rheumatoid arthritis, and

4. Learn more about the factors that contribute to the development or progression fibrotic lung disease.

Sponsoring Institute:

National Human Genome Research Institute (NHGRI)

Recruitment Detail

Type: Completed Study; data analyses ongoing

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): Children

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Currently Not Provided

Keyword(s):

Interstitial Lung Disease

Collagen Vascular Disease

Extracellular Matrix

Pulmonary Function

DTPA Lung Clearance Scan

Recruitment Keyword(s):

Rheumatoid Arthritis

Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis

Condition(s):

Pulmonary Fibrosis

Rheumatoid Arthritis

Investigational Drug(s):

None

Investigational Device(s):

None

Interventions:

None

Supporting Site:

National Heart, Lung and Blood Institute

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Pulmonary fibrosis in rheumatoid arthritis: a review of clinical features and therapy

Pulmonary involvement in rheumatoid arthritis

Rheumatoid arthritis lung disease Determinants of radiographic and physiologic abnormalities

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department Clinical Research Informatics, CC.

Search The Studies | Help | Questions |
Clinical Center Home | NIH Home

National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/30/2009