| | Principal Investigators
| Daniel Pine,
M.D. |
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Dr.
Daniel Pine is currently Chief, Section
on Development and Affective Neuroscience and
Chief of Emotion and Development Branch in the Mood and Anxiety Disorders Program
of the National Institute of Mental Health Intramural
Research Program. Dr. Pine moved to this position in the
fall of 2000, after 10 years of training, teaching, and
research at the Department of Child and Adolescent Psychiatry
in the New York State Psychiatric Institute and the College
of Physicians and Surgeons of Columbia University. Since
graduating from medical school at the University of Chicago,
Dr. Pine has been engaged continuously in research focusing
on the epidemiology, biology and treatment of psychiatric
disorders in children and adolescents. His areas of expertise
include biological and pharmacological aspects of mood,
anxiety, and behavioral disorders in children, as reflected
in a series of more than 80 papers on these topics. Dr.
Pine also possesses expertise in the biological commonalities
and differences among psychiatric disorders of children,
adolescents, and adults as well as on interfaces between
psychiatric and medical disorders. Dr. Pine has received
a number of awards, including Career Development and R01
extramural grant support from the NIMH, a NARSAD Independent
Investigator Award, as well as the Blanche Ittelson Award
from the American Psychiatric Association for outstanding
research contributions to the field of child psychiatry. |
| Research Interests |
My
research interests as an academic child psychiatrist pursue
two complimentary avenues. First, I am testing hypotheses
on brain-behavior associations in childhood psychopathology.
Second, I am an active investigator in pediatric psychopharmacology.
With respect to brain-behavior associations, I have conducted
a series of studies examining the pathophysiology of anxiety
disorders in children and adults over the past decade.
Much of my initial work in this are relied upon psychophysiologic
or neuropsychological experimental paradigms. |
| Representative Selected Recent Publications: |
- The RUPP Anxiety Study Group (DS Pine, corresponding author):
Fluvoxamine for anxiety disorders in children and adolescents.
N Engl J Med, 2001; 344: 1279-1285.
- Monk CS, Nelson E, Woldehawariat G , Montgomery LA, Zarahn E, McClure EB, Schweder AE, Leibenluft, Charney DS, Ernst M, Pine DS:
Experience-dependent plasticity for attention to threat: behavioral and neurophysiological evidence in humans.
Biol Psychiatry, 2004 Oct 15; 56(8): 607-10.
- Pine DS, Mogg K, Bradley B, Montgomery LA, Monk CS, McClure E, Schweder A, Ernst M, Charney DS, Kaufman J:
Attention bias to threat in maltreated children: implications for vulnerability to stress-related psychopathology.
Am J Psychiatry, Feb; 162(2): 291-6, 2005.
- Nelson EE, Leibenluft E, McClure E, Pine DS:
The social re-orientation of adolescence: a neuroscience perspective on the process and its relation to psychopathology.
Psychol Med, (in press).
- Pine DS, Klein RG, Roberson-Nay R, Mannuzza S, Moulton J, Guardino M, Woldehawariat G:
Response to 5% CO2 in juveniles: relationship to panic disorder in parents and anxiety disorders in offspring.
Arch Gen Psychiatry, (in press).
- Ernst M, Nelson EE, Jazbec S, McClure EB, Monk CS, Leibenluft E, Blair J, Pine DS:
Amygdala and nucleus accumbens in response to receipt and omission of gains in adults and adolescents.
NeuroImage, (in press).
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