Protocol Number: 03-CC-0128

Title:

Development and Evaluation of Techniques for Computer Aided Detection and Diagnosis from Radiologic Images

Number:

03-CC-0128

Summary:

This study will develop and evaluate new techniques for computer-aided detection and diagnosis (CAD) of medical problems using images from diagnostic tests such as computed tomography (CT), ultrasound, nuclear medicine and x-ray images. The Food and Drug Administration has approved CAD techniques for detecting masses and calcifications on mammography and lung nodules using chest x-rays. Many other applications of CAD would potentially benefit patients. This study will explore additional uses of CAD.

The study will use imaging data, demographic information, and other medical information from the medical charts of Clinical Center patients to test and evaluate new CAD applications. Such applications include detection of subcutaneous (under the skin) lesions in melanoma patients, bone lesions in patients with advanced cancer, and pulmonary emboli (blood clot lodged in a lung artery) in patients who are known to have pulmonary emboli, and other uses.

Sponsoring Institute:

National Institutes of Health Clinical Center (CC)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Inclusion criteria are the availability of radiologic examinations in the clinical PACS (picture archiving system) in the Clinical Center. Patients with and without the target lesion will be included. Examples of target lesions include subcutaneous and bone lesions and pulmonary emboli, although patients with other disorders depicted on radiologic studies may be included when appropriate. Patients without the target lesion may be included to determine the specificity of the computer aided detection or diagnosis algorithm.

EXCLUSION CRITERIA:

There are no exclusion criteria.

Special Instructions:

Currently Not Provided

Keywords:

None

Recruitment Keyword(s):

Healthy Volunteer

HV

Condition(s):

Diagnostic Imaging

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

Warren G. Magnuson Clinical Center

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Erickson, BJ. Computer-aided detection and diagnosis at the start of the third millennium. J Digit Imaging. 2002 Jun;15(2):59-68. Review. PMID: 12297976

Summers RM. Colonic polyps: complementary role of computer-aided detection in CT colonography. Radiology. 2002 Nov;225(2):391-9. PMID: 12409571

Summers RM. Polypoid lesions of airways: early experience with computer-assisted detection by using virtual bronchoscopy and surface curvature. Radiology. 1998 Aug;208(2):331-7. PMID: 9680555

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Clinical Research Informatics, CC.

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