Protocol Number: 03-CC-0015
Normal volunteers and patients with the following diseases or conditions may be eligible for this study: - Sickle cell disease - Arteriosclerosis (hardening of the arteries) - Hemolytic diseases (diseases involving destruction of red blood cells) - Sepsis (infection of the blood or other tissues) - Other diseases involving inflammation and the endothelium (lining cells of the heart, blood and lymph vessels, and cavities of the body) Participants must be at least 5 years old. All participants will give a medical history and have a physical examination. Sickle cell patients and healthy volunteers will have tests to determine if they have sickle cell disease, sickle cell trait, or beta-thalassemia. All participants will donate blood from either a vein or an artery. To collect blood from a vein, a needle is placed in a vein in the bend of the elbow and blood is drawn into several syringes or tubes. To collect blood from an artery, a needle is placed in an artery in the arm above the elbow or in an artery on the wrist and blood is drawn into several syringes or tubes. (Arterial blood will be drawn only from participants 18 years of age or older.) No more than 450 ml (about 1 pint) of blood will be collected from any donor over an 8-week period.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/30/2009
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