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Volume 36(20);  November 2008
Front-Matter/Back-Matter
Nucleic Acids Research: VOLUME 36 ISSUE 20 2008
Nucleic Acids Res. 2008 November; 36(20): i. Published online 2008 November. doi: 10.1093/nar/gkn950.
PMCID: PMC2582598
Nucleic Acids Research
Nucleic Acids Res. 2008 November; 36(20): ii. Published online 2008 November. doi: 10.1093/nar/gkn949.
PMCID: PMC2582623
Subscriptions
Nucleic Acids Res. 2008 November; 36(20): iii. Published online 2008 November. doi: 10.1093/nar/gkn951.
PMCID: PMC2582605
Gene regulation, Chromatin and Epigenetics
Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism
Su Mi Choi, Hyun-Ju Cho, Heesang Cho, Kang Ho Kim, Jae Bum Kim, and Hyunsung Park
Nucleic Acids Res. 2008 November; 36(20): 6372–6385. Published online 2008 November. doi: 10.1093/nar/gkn620.
PMCID: PMC2582599
The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications
Philipp Jahnke, Weizhen Xu, Manuela Wülling, Melanie Albrecht, Heinz Gabriel, Gabriele Gillessen-Kaesbach, and Frank J. Kaiser
Nucleic Acids Res. 2008 November; 36(20): 6450–6458. Published online 2008 November. doi: 10.1093/nar/gkn688.
PMCID: PMC2582609
Analysis of regulatory network topology reveals functionally distinct classes of microRNAs
Xueping Yu, Jimmy Lin, Donald J. Zack, Joshua T. Mendell, and Jiang Qian
Nucleic Acids Res. 2008 November; 36(20): 6494–6503. Published online 2008 November. doi: 10.1093/nar/gkn712.
PMCID: PMC2582613
CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene
Thomas Langmann, Christine C. L. Lai, Karin Weigelt, Beatrice M. Tam, Regina Warneke-Wittstock, Orson L. Moritz, and Bernhard H. F. Weber
Nucleic Acids Res. 2008 November; 36(20): 6523–6534. Published online 2008 November. doi: 10.1093/nar/gkn737.
PMCID: PMC2582616
NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations
Raffaella Gatta and Roberto Mantovani
Nucleic Acids Res. 2008 November; 36(20): 6592–6607. Published online 2008 November. doi: 10.1093/nar/gkn699.
PMCID: PMC2582630
Genome Integrity, Repair and Replication
Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
Wei He, Yun Zhao, Chunbo Zhang, Lili An, Zhishang Hu, Yuheng Liu, Lu Han, Lijun Bi, Zhensheng Xie, Peng Xue, Fuquan Yang, and Haiying Hang
Nucleic Acids Res. 2008 November; 36(20): 6406–6417. Published online 2008 November. doi: 10.1093/nar/gkn686.
PMCID: PMC2582629
Rad51 gain-of-function mutants that exhibit high affinity DNA binding cause DNA damage sensitivity in the absence of Srs2
Punjab S. Malik and Lorraine S. Symington
Nucleic Acids Res. 2008 November; 36(20): 6504–6510. Published online 2008 November. doi: 10.1093/nar/gkn720.
PMCID: PMC2582631
Molecular Biology
Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure–activity studies
Rachida Abes, Hong M. Moulton, Philippe Clair, Sung-Tae Yang, Said Abes, Kamran Melikov, Paul Prevot, Derek S. Youngblood, Patrick L. Iversen, Leonid V. Chernomordik, and Bernard Lebleu
Nucleic Acids Res. 2008 November; 36(20): 6343–6354. Published online 2008 November. doi: 10.1093/nar/gkn541.
PMCID: PMC2582615
Regional mutagenesis of the gene encoding the phage Mu late gene activator C identifies two separate regions important for DNA binding
Yide Jiang and Martha M. Howe
Nucleic Acids Res. 2008 November; 36(20): 6396–6405. Published online 2008 November. doi: 10.1093/nar/gkn639.
PMCID: PMC2582627
Improved cell-penetrating peptide–PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle
Gabriela D. Ivanova, Andrey Arzumanov, Rachida Abes, Haifang Yin, Matthew J. A. Wood, Bernard Lebleu, and Michael J. Gait
Nucleic Acids Res. 2008 November; 36(20): 6418–6428. Published online 2008 November. doi: 10.1093/nar/gkn671.
PMCID: PMC2582604
Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase
Alexandra Dimitri, John A. Burns, Suse Broyde, and David A. Scicchitano
Nucleic Acids Res. 2008 November; 36(20): 6459–6471. Published online 2008 November. doi: 10.1093/nar/gkn657.
PMCID: PMC2582612
Epstein–Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway
Graziana Gatto, Annalisa Rossi, Daniela Rossi, Sven Kroening, Stefano Bonatti, and Massimo Mallardo
Nucleic Acids Res. 2008 November; 36(20): 6608–6619. Published online 2008 November. doi: 10.1093/nar/gkn666.
PMCID: PMC2582607
RNA
Evolution of Arabidopsis MIR genes generates novel microRNA classes
Franck Vazquez, Todd Blevins, Jérôme Ailhas, Thomas Boller, and Frederick Meins, Jr
Nucleic Acids Res. 2008 November; 36(20): 6429–6438. Published online 2008 November. doi: 10.1093/nar/gkn670.
PMCID: PMC2582634
Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells
Thomas Ohrt, Jörg Mütze, Wolfgang Staroske, Lasse Weinmann, Julia Höck, Karin Crell, Gunter Meister, and Petra Schwille
Nucleic Acids Res. 2008 November; 36(20): 6439–6449. Published online 2008 November. doi: 10.1093/nar/gkn693.
PMCID: PMC2582625
Translation affects YoeB and MazF messenger RNA interferase activities by different mechanisms
Mikkel Christensen-Dalsgaard and Kenn Gerdes
Nucleic Acids Res. 2008 November; 36(20): 6472–6481. Published online 2008 November. doi: 10.1093/nar/gkn667.
PMCID: PMC2582610
A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs
Harris S. Soifer, Masayuki Sano, Kumi Sakurai, Pritsana Chomchan, Pål Sætrom, Mark A. Sherman, Michael A. Collingwood, Mark A. Behlke, and John J. Rossi
Nucleic Acids Res. 2008 November; 36(20): 6511–6522. Published online 2008 November. doi: 10.1093/nar/gkn687.
PMCID: PMC2582626
Synthesis and investigation of the 5-formylcytidine modified, anticodon stem and loop of the human mitochondrial tRNAMet
Hrvoje Lusic, Estella M. Gustilo, Franck A.P. Vendeix, Rob Kaiser, Michael O. Delaney, William D. Graham, Virginia A. Moye, William A. Cantara, Paul F. Agris, and Alexander Deiters
Nucleic Acids Res. 2008 November; 36(20): 6548–6557. Published online 2008 November. doi: 10.1093/nar/gkn703.
PMCID: PMC2582600
Novel mechanism of hexamer ring assembly in protein/RNA interactions revealed by single molecule imaging
Feng Xiao, Hui Zhang, and Peixuan Guo
Nucleic Acids Res. 2008 November; 36(20): 6620–6632. Published online 2008 November. doi: 10.1093/nar/gkn669.
PMCID: PMC2582624
Structural Biology
The N-clasp of human DNA polymerase κ promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions
Lei Jia, Nicholas E. Geacintov, and Suse Broyde
Nucleic Acids Res. 2008 November; 36(20): 6571–6584. Published online 2008 November. doi: 10.1093/nar/gkn719.
PMCID: PMC2582633
Structural explanation for the role of Mn2+ in the activity of ϕ6 RNA-dependent RNA polymerase
Minna M. Poranen, Paula S. Salgado, Minni R. L. Koivunen, Sam Wright, Dennis H. Bamford, David I. Stuart, and Jonathan M. Grimes
Nucleic Acids Res. 2008 November; 36(20): 6633–6644. Published online 2008 November. doi: 10.1093/nar/gkn632.
PMCID: PMC2582606
Survey and Summary
The assembly of a spliceosomal small nuclear ribonucleoprotein particle
Snehal Bhikhu Patel and Michel Bellini
Nucleic Acids Res. 2008 November; 36(20): 6482–6493. Published online 2008 November. doi: 10.1093/nar/gkn658.
PMCID: PMC2582628
Genomics
Low conservation and species-specific evolution of alternative splicing in humans and mice: comparative genomics analysis using well-annotated full-length cDNAs
Jun-ichi Takeda, Yutaka Suzuki, Ryuichi Sakate, Yoshiharu Sato, Masahide Seki, Takuma Irie, Nono Takeuchi, Takuya Ueda, Mitsuteru Nakao, Sumio Sugano, Takashi Gojobori, and Tadashi Imanishi
Nucleic Acids Res. 2008 November; 36(20): 6386–6395. Published online 2008 November. doi: 10.1093/nar/gkn677.
PMCID: PMC2582632
Whole genome exon arrays identify differential expression of alternatively spliced, cancer-related genes in lung cancer
Liqiang Xi, Andrew Feber, Vanita Gupta, Maoxin Wu, Andrew D. Bergemann, Rodney J. Landreneau, Virginia R. Litle, Arjun Pennathur, James D. Luketich, and Tony E. Godfrey
Nucleic Acids Res. 2008 November; 36(20): 6535–6547. Published online 2008 November. doi: 10.1093/nar/gkn697.
PMCID: PMC2582617
Methods Online
A sensitive array-based assay for identifying multiple TMPRSS2:ERG fusion gene variants
Qing Lu, Esperanza Nunez, Chunrun Lin, Kimberly Christensen, Tracy Downs, Dennis A. Carson, Jessica Wang-Rodriguez, and Yu-Tsueng Liu
Nucleic Acids Res. 2008 November; 36(20): e130. Published online 2008 November. doi: 10.1093/nar/gkn585.
PMCID: PMC2582611
Hot Start PCR with heat-activatable primers: a novel approach for improved PCR performance
Alexandre V. Lebedev, Natasha Paul, Joyclyn Yee, Victor A. Timoshchuk, Jonathan Shum, Kei Miyagi, Jack Kellum, Richard I. Hogrefe, and Gerald Zon
Nucleic Acids Res. 2008 November; 36(20): e131. Published online 2008 November. doi: 10.1093/nar/gkn575.
PMCID: PMC2582603
Multi-stringency wash of partially hybridized 60-mer probes reveals that the stringency along the probe decreases with distance from the microarray surface
Lena Poulsen, Martin Jensen Søe, Detlef Snakenborg, Lisbeth Birk Møller, and Martin Dufva
Nucleic Acids Res. 2008 November; 36(20): e132. Published online 2008 November. doi: 10.1093/nar/gkn600.
PMCID: PMC2582620
Enhanced gene trapping in mouse embryonic stem cells
Frank Schnütgen, Jens Hansen, Silke De-Zolt, Carsten Horn, Marcus Lutz, Thomas Floss, Wolfgang Wurst, Patricia Ruiz Noppinger, and Harald von Melchner
Nucleic Acids Res. 2008 November; 36(20): e133. Published online 2008 November. doi: 10.1093/nar/gkn603.
PMCID: PMC2582619
In vivo evaluation of PhiC31 recombinase activity using a self-excision cassette
Eugenio Sangiorgi, Zhang Shuhua, and Mario R. Capecchi
Nucleic Acids Res. 2008 November; 36(20): e134. Published online 2008 November. doi: 10.1093/nar/gkn627.
PMCID: PMC2582622
Analysis of factor interactions with RNA polymerase II elongation complexes using a new electrophoretic mobility shift assay
Bo Cheng and David H. Price
Nucleic Acids Res. 2008 November; 36(20): e135. Published online 2008 November. doi: 10.1093/nar/gkn630.
PMCID: PMC2582608
Protein networks markedly improve prediction of subcellular localization in multiple eukaryotic species
KiYoung Lee, Han-Yu Chuang, Andreas Beyer, Min-Kyung Sung, Won-Ki Huh, Bonghee Lee, and Trey Ideker
Nucleic Acids Res. 2008 November; 36(20): e136. Published online 2008 November. doi: 10.1093/nar/gkn619.
PMCID: PMC2582614
Gene expression module-based chemical function similarity search
Yun Li, Pei Hao, Siyuan Zheng, Kang Tu, Haiwei Fan, Ruixin Zhu, Guohui Ding, Changzheng Dong, Chuan Wang, Xuan Li, H.-J. Thiesen, Y. Eugene Chen, Hualiang Jiang, Lei Liu, and Yixue Li
Nucleic Acids Res. 2008 November; 36(20): e137. Published online 2008 November. doi: 10.1093/nar/gkn610.
PMCID: PMC2582597
Computational Biology
Unifying evolutionary and thermodynamic information for RNA folding of multiple alignments
Stefan E. Seemann, Jan Gorodkin, and Rolf Backofen
Nucleic Acids Res. 2008 November; 36(20): 6355–6362. Published online 2008 November. doi: 10.1093/nar/gkn544.
PMCID: PMC2582601
A competitive hybridization model predicts probe signal intensity on high density DNA microarrays
Shuzhao Li, Alex Pozhitkov, and Marius Brouwer
Nucleic Acids Res. 2008 November; 36(20): 6585–6591. Published online 2008 November. doi: 10.1093/nar/gkn740.
PMCID: PMC2582621
Nucleic Acid Enzymes
Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids
Chandravanu Dash, Brian J. Scarth, Christopher Badorrek, Matthias Götte, and Stuart F. J. Le Grice
Nucleic Acids Res. 2008 November; 36(20): 6363–6371. Published online 2008 November. doi: 10.1093/nar/gkn678.
PMCID: PMC2582618
MmeI: a minimal Type II restriction-modification system that only modifies one DNA strand for host protection
Richard D. Morgan, Tanya K. Bhatia, Lindsay Lovasco, and Theodore B. Davis
Nucleic Acids Res. 2008 November; 36(20): 6558–6570. Published online 2008 November. doi: 10.1093/nar/gkn711.
PMCID: PMC2582602
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