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Volume 2(4);  October 2005
Editorial
Drug Discovery for Disorders of the Central Nervous System
Menelas N. Pangalos and Christopher C. Gallen
NeuroRx. 2005 October; 2(4): 539–540.
PMCID: PMC1201313
Review Articles
Medicinal Chemical Properties of Successful Central Nervous System Drugs
Hassan Pajouhesh and George R. Lenz
NeuroRx. 2005 October; 2(4): 541–553.
PMCID: PMC1201314
Drug Metabolism and Pharmacokinetics, the Blood-Brain Barrier, and Central Nervous System Drug Discovery
Mohammad S. Alavijeh, Mansoor Chishty, M. Zeeshan Qaiser, and Alan M. Palmer
NeuroRx. 2005 October; 2(4): 554–571.
PMCID: PMC1201315
The Quest for Market Exclusivity in Biotechnology: Navigating the Patent Minefield
Judge David M. Gersten
NeuroRx. 2005 October; 2(4): 572–578.
PMCID: PMC1201316
Developing Therapeutics for Schizophrenia and Other Psychotic Disorders
Gerard Marek and Kalpana Merchant
NeuroRx. 2005 October; 2(4): 579–589.
PMCID: PMC1201317
Innovative Approaches for the Development of Antidepressant Drugs: Current and Future Strategies
Lee E. Schechter, Robert H. Ring, Chad E. Beyer, Zoë A. Hughes, Xavier Khawaja, Jessica E. Malberg, and Sharon Rosenzweig-Lipson
NeuroRx. 2005 October; 2(4): 590–611.
PMCID: PMC1201318
Current Concepts in Therapeutic Strategies Targeting Cognitive Decline and Disease Modification in Alzheimer’s Disease
J. Steven Jacobsen, Peter Reinhart, and Menelas N. Pangalos
NeuroRx. 2005 October; 2(4): 612–626.
PMCID: PMC1201319
New Prospects and Strategies for Drug Target Discovery in Neurodegenerative Disorders
Brian S. Hilbush, John H. Morrison, Warren G. Young, J. Gregor Sutcliffe, and Floyd E. Bloom
NeuroRx. 2005 October; 2(4): 627–637.
PMCID: PMC1201320
Developing Therapeutics for the Treatment of Multiple Sclerosis
David J. Virley
NeuroRx. 2005 October; 2(4): 638–649.
PMCID: PMC1201321
Challenges in the Development of Novel Treatment Strategies for Neuropathic Pain
Michael H. Ossipov and Frank Porreca
NeuroRx. 2005 October; 2(4): 650–661.
PMCID: PMC1201322
Targeting Chronic and Neuropathic Pain: The N-type Calcium Channel Comes of Age
Terrance P. Snutch
NeuroRx. 2005 October; 2(4): 662–670.
PMCID: PMC1201323
Translational Research in Central Nervous System Drug Discovery
Orest Hurko and John L. Ryan
NeuroRx. 2005 October; 2(4): 671–682.
PMCID: PMC1201324
Central Nervous System Drug Development: An Integrative Biomarker Approach toward Individualized Medicine
B. Gomez-Mancilla, E. Marrer, J. Kehren, A. Kinnunen, G. Imbert, R. Hillebrand, M. Bergström, and M. E. Schmidt
NeuroRx. 2005 October; 2(4): 683–695.
PMCID: PMC1201325
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Am. Soc. for Experimental NeuroTherapeutics