| | This journal provides immediate access to some articles. Commentaries Chemoprevention: Increased potential to bear fruit C. Roland Wolf PMCID: PMC33333 Closing down on glyphosate inhibition—with a new structure for
drug discovery Murtaza F. Alibhai and William C. Stallings PMCID: PMC33334 Calcineurin inhibition and cardiac hypertrophy: A matter
of balance Leslie A. Leinwand PMCID: PMC33335 Right on target: Novel approaches for the direct visualization of
CD1-specific T cell responses Mitchell Kronenberg, Olga Naidenko, and Frits Koning PMCID: PMC33336 Hand morphology, manipulation, and tool use in Neandertals and
early modern humans of the Near East Steven E. Churchill PMCID: PMC33337 The increasingly plastic, hormone-responsive adult brain S. Marc Breedlove and Cynthia L. Jordan PMCID: PMC33338 Breaking open a protein barrel Neville Kallenbach PMCID: PMC33339 Physical Sciences Applied Physical Sciences From the Cover:
Using three-dimensional microfluidic networks for solving
computationally hard problems Daniel T. Chiu, Elena Pezzoli, Hongkai Wu, Abraham D. Stroock, and George M. Whitesides PMCID: PMC30589 Chemistry Global analysis of proteasomal substrate specificity using
positional-scanning libraries of covalent inhibitors Tamim Nazif and Matthew Bogyo PMCID: PMC30590 Logic gates using high Rydberg states F. Remacle, E. W. Schlag, H. Selzle, K. L. Kompa, U. Even, and R. D. Levine PMCID: PMC30591 Biological Sciences Anthropology Behavioral inferences from the Skhul/Qafzeh early modern human
hand remains Wesley A. Niewoehner PMCID: PMC30592 Biochemistry Global analysis of proteasomal substrate specificity using
positional-scanning libraries of covalent inhibitors Tamim Nazif and Matthew Bogyo PMCID: PMC30590 Mapping the early steps in the pH-induced conformational
conversion of the prion protein Darwin O. V. Alonso, Stephen J. DeArmond, Fred E. Cohen, and Valerie Daggett PMCID: PMC30593 Identification of protein oligomerization states by analysis of
interface conservation Adrian H. Elcock and J. Andrew McCammon PMCID: PMC30594 Structure of a flavin-binding plant photoreceptor domain:
Insights into light-mediated signal transduction Sean Crosson and Keith Moffat PMCID: PMC30595 Assembly of the neutrophil respiratory burst oxidase: A direct
interaction between p67PHOX and
cytochrome b558 Pham My-Chan Dang, Andrew R. Cross, and Bernard M. Babior PMCID: PMC30596 Comparing protein–ligand interactions in solution and single
crystals by Raman spectroscopy Michael D. Altose, Yuangang Zheng, Jian Dong, Bruce A. Palfey, and Paul R. Carey PMCID: PMC30597 Solution structure of the antiapoptotic protein bcl-2 Andrew M. Petros, Ales Medek, David G. Nettesheim, Daniel H. Kim, Ho Sup Yoon, Kerry Swift, Edmund D. Matayoshi, Tilman Oltersdorf, and Stephen W. Fesik PMCID: PMC30598 From transforming growth factor-β signaling to androgen action:
Identification of Smad3 as an androgen receptor coregulator in prostate cancer cells Hong-Yo Kang, Hui-Kuan Lin, Yueh-Chiang Hu, Shuyuan Yeh, Ko-En Huang, and Chawnshang Chang PMCID: PMC30599 An initial ATP-independent step in the unwinding of a herpes
simplex virus type I origin of replication by a complex of the viral
origin-binding protein and single-strand DNA-binding protein Xiaodun He and I. R. Lehman PMCID: PMC30600 Male fertility defects in mice lacking the serine protease
inhibitor protease nexin-1 Valérie Murer, Jean François Spetz, Ulrich Hengst, Ludger Maria Altrogge, Ariane de Agostini, and Denis Monard PMCID: PMC30601 Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-γ Christopher J. DaFonseca, Fong Shu, and J. Jillian Zhang PMCID: PMC30602 Protein factors associated with the SsrA ![[center dot]](corehtml/pmc/pmcents/middot.gif) SmpB tagging and
ribosome rescue complex A. Wali Karzai and Robert T. Sauer PMCID: PMC30603 Mechanism of topology simplification by type II
DNA topoisomerases Alexander V. Vologodskii, Wentao Zhang, Valentin V. Rybenkov, Alexei A. Podtelezhnikov, Deepa Subramanian, Jack D. Griffith, and Nicholas R. Cozzarelli PMCID: PMC30604 A yeast-like mRNA capping apparatus in
Plasmodium falciparum C. Kiong Ho and Stewart Shuman PMCID: PMC30605 RPN4 is a ligand, substrate, and transcriptional regulator of the
26S proteasome: A negative feedback circuit Youming Xie and Alexander Varshavsky PMCID: PMC30606 Telomerase inhibitors based on quadruplex ligands selected by a
fluorescence assay Jean-Louis Mergny, Laurent Lacroix, Marie-Paule Teulade-Fichou, Candide Hounsou, Lionel Guittat, Magali Hoarau, Paola B. Arimondo, Jean-Pierre Vigneron, Jean-Marie Lehn, Jean-François Riou, Thérèse Garestier, and Claude Hélène PMCID: PMC30607 Crystal structure of cytochrome P450 14α-sterol demethylase
(CYP51) from Mycobacterium tuberculosis in complex with
azole inhibitors Larissa M. Podust, Thomas L. Poulos, and Michael R. Waterman PMCID: PMC30608 Mapping the intrinsic curvature and flexibility along the
DNA chain Giampaolo Zuccheri, Anita Scipioni, Valeria Cavaliere, Giuseppe Gargiulo, Pasquale De Santis, and Bruno Samorì PMCID: PMC30609 Protein phosphatase 1 regulation by inhibitors and
targeting subunits Takuo Watanabe, Hsien-Bin Huang, Atsuko Horiuchi, Edgar F. da Cruze Silva, Linda Hsieh-Wilson, Patrick B. Allen, Shirish Shenolikar, Paul Greengard, and Angus C. Nairn PMCID: PMC30610 Herpes simplex virus DNA packaging sequences adopt novel
structures that are specifically recognized by a component of the
cleavage and packaging machinery Karen Adelman, Brandy Salmon, and Joel D. Baines PMCID: PMC30611 From the Cover:
Reverse engineering the (β/α)8
barrel fold J. A. Silverman, R. Balakrishnan, and P.
B. Harbury PMCID: PMC30612 Synechocystis HSP17 is an amphitropic protein that
stabilizes heat-stressed membranes and binds denatured proteins for
subsequent chaperone-mediated refolding Zsolt Török, Pierre Goloubinoff, Ibolya Horváth, Nelly M. Tsvetkova, Attila Glatz, Gábor Balogh, Viktória Varvasovszki, Dmitry A. Los, Elizabeth Vierling, John H. Crowe, and László Vígh PMCID: PMC30613 Human fatty acid synthase: Role of interdomain in the formation
of catalytically active synthase dimer Subrahmanyam S. Chirala, Armugam Jayakumar, Zi-Wei Gu, and Salih J. Wakil PMCID: PMC30614 Altering dimerization specificity by changes in
surface electrostatics M. J. Nohaile, Z. S. Hendsch, B. Tidor, and R. T. Sauer PMCID: PMC30615 Crystal structure of the C-terminal domain of the RAP74 subunit
of human transcription factor IIF Katsuhiko Kamada, Jacqueline De
Angelis, Robert G. Roeder, and Stephen K. Burley PMCID: PMC30616 Toward a quantum-mechanical description of metal-assisted
phosphoryl transfer in pyrophosphatase P. Heikinheimo, V. Tuominen, A.-K. Ahonen, A. Teplyakov, B. S. Cooperman, A. A. Baykov, R. Lahti, and A. Goldman PMCID: PMC30617 Structure of neurolysin reveals a deep channel that limits
substrate access C. Kent Brown, Kevin Madauss, Wei Lian, Moriah R. Beck, W. David Tolbert, and David W. Rodgers PMCID: PMC30618 Biophysics NMR structure of the calreticulin P-domain Lars Ellgaard, Roland Riek, Torsten Herrmann, Peter Güntert, Daniel Braun, Ari Helenius, and Kurt Wüthrich PMCID: PMC30619 Point mutations and sequence variability in proteins:
Redistributions of preexisting populations Neeti Sinha and Ruth Nussinov PMCID: PMC30620 Dissipative metabolic patterns respond during neutrophil
transmembrane signaling Howard R. Petty and Andrei L. Kindzelskii PMCID: PMC30621 Direct observation of the enhancement of noncooperative protein
self-assembly by macromolecular crowding: Indefinite linear
self-association of bacterial cell division protein FtsZ Germán Rivas, Javier A. Fernández, and Allen P. Minton PMCID: PMC30622 Cell Biology p63 identifies keratinocyte stem cells Graziella Pellegrini, Elena Dellambra, Osvaldo Golisano, Enrica Martinelli, Ivana Fantozzi, Sergio Bondanza, Diego Ponzin, Frank McKeon, and Michele De Luca PMCID: PMC30623 Arp2/3 complex and actin dynamics are required for actin-based
mitochondrial motility in yeast Istvan R. Boldogh, Hyeong-Cheol Yang, W. Dan Nowakowski, Sharon L. Karmon, Lara G. Hays, John R. Yates, III, and Liza A. Pon PMCID: PMC30624 Activation of Trp3 by inositol 1,4,5-trisphosphate receptors
through displacement of inhibitory calmodulin from a common
binding domain Zongming Zhang, Jisen Tang, Svetlana Tikunova, J. David Johnson, Zhangguo Chen, Ning Qin, Alexander Dietrich, Enrico Stefani, Lutz Birnbaumer, and Michael Xi Zhu PMCID: PMC30625 Recombination-mediated lengthening of terminal telomeric
repeats requires the Sgs1 DNA helicase Haim Cohen and David A. Sinclair PMCID: PMC30626 Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon
IgE-triggered cell signaling Frank Lafont and Kai Simons PMCID: PMC30627 Delivery of proteins into living cells by reversible membrane
permeabilization with streptolysin-O Iwan Walev, Sebastian Chakrit Bhakdi, Fred Hofmann, Nabil Djonder, Angela Valeva, Klaus Aktories, and Sucharit Bhakdi PMCID: PMC30628 Disruption of the FG nucleoporin NUP98 causes selective changes
in nuclear pore complex stoichiometry and function Xiaosheng Wu, Lawryn H. Kasper, Ralitsa T. Mantcheva, George T. Mantchev, Margaret J. Springett, and Jan M. A. van Deursen PMCID: PMC30629 Circularly permuted green fluorescent proteins engineered to
sense Ca2+ Takeharu Nagai, Asako Sawano, Eun Sun Park, and Atsushi Miyawaki PMCID: PMC30630 A transcriptional corepressor of Stat1 with an essential LXXLL
signature motif Bin Liu, Mitchell Gross, Johanna ten Hoeve, and Ke Shuai PMCID: PMC30631 The nucleoporin Nup98 associates with the intranuclear
filamentous protein network of TPR Beatriz M. A. Fontoura, Samuel Dales, Günter Blobel, and Hualin Zhong PMCID: PMC30632 Tissue-engineered cells producing complex recombinant proteins
inhibit ovarian cancer in vivo Antonia E. Stephen, Peter T. Masiakos, Dorry L. Segev, Joseph P. Vacanti, Patricia K. Donahoe, and David T. MacLaughlin PMCID: PMC30633 Cloning and mitochondrial localization of full-length D-AKAP2, a
protein kinase A anchoring protein Lin Wang, Roger K. Sunahara, Andrejs Krumins, Guy Perkins, Marsha L. Crochiere, Mason Mackey, Sean Bell, Mark H. Ellisman, and Susan S. Taylor PMCID: PMC30634 Evolution Predicting crossover generation in DNA shuffling Gregory L. Moore, Costas D. Maranas, Stefan Lutz, and Stephen J. Benkovic PMCID: PMC30635 Genetics A single nucleotide polymorphism in the RAD51 gene
modifies cancer risk in BRCA2 but not BRCA1 carriers E. Levy-Lahad, A. Lahad, S. Eisenberg, E. Dagan, T. Paperna, L. Kasinetz, R. Catane, B. Kaufman, U. Beller, P. Renbaum, and R. Gershoni-Baruch PMCID: PMC30636 Murine cytomegalovirus M78 protein, a G protein-coupled
receptor homologue, is a constituent of the virion and facilitates
accumulation of immediate-early viral mRNA Sofia A. Oliveira and Thomas E. Shenk PMCID: PMC30637 Genetic interactions between ATM and the nonhomologous
end-joining factors in genomic stability and development JoAnn Sekiguchi, David O. Ferguson, Hua Tang Chen, Eva Mary Yang, John Earle, Karen Frank, Scott Whitlow, Yansong Gu, Yang Xu, André Nussenzweig, and Frederick W. Alt PMCID: PMC30638 Genomic evidence for a complete sexual cycle in
Candida albicans Keh-Weei Tzung, Roy M. Williams, Stewart Scherer, Nancy Federspiel, Ted Jones, Nancy Hansen, Vesna Bivolarevic, Lucas Huizar, Caridad Komp, Ray Surzycki, Raquel Tamse, Ronald W. Davis, and Nina Agabian PMCID: PMC30639 ACVR1B (ALK4, activin receptor type
1B) gene mutations in pancreatic carcinoma Gloria H. Su, Ravi Bansal, Kathleen M. Murphy, Elizabeth Montgomery, Charles J. Yeo, Ralph H. Hruban, and Scott E. Kern PMCID: PMC30640 The second STE12 homologue of Cryptococcus
neoformans is MATa-specific and plays an important role in virulence Y. C. Chang, L. A. Penoyer, and K. J. Kwon-Chung PMCID: PMC30641 Immunology Toward optimized carbohydrate-based anticancer vaccines: Epitope
clustering, carrier structure, and adjuvant all influence antibody
responses to Lewisy conjugates in mice Valery Kudryashov, Peter W. Glunz, Lawrence J. Williams, Samuel Hintermann, Samuel J. Danishefsky, and Kenneth O. Lloyd PMCID: PMC30642 Immunization of metastatic breast cancer patients with a fully
synthetic globo H conjugate: A phase I trial Teresa Gilewski, Govindaswami Ragupathi, Sonal Bhuta, Lawrence J. Williams, Cristina Musselli, Xu-Fang Zhang, Kalman P. Bencsath, Katherine S. Panageas, Jeanette Chin, Clifford A. Hudis, Larry Norton, Alan N. Houghton, Philip O. Livingston, and Samuel J. Danishefsky PMCID: PMC30643 Indirect recognition of allopeptides promotes the development of
cardiac allograft vasculopathy Richard S. Lee, Kazuhiko Yamada, Stuart L. Houser, Karl L. Womer, Michaella E. Maloney, Harris S. Rose, Mohamed H. Sayegh, and Joren C. Madsen PMCID: PMC30644 Identification of proacrosin binding protein sp32 precursor as a
human cancer/testis antigen Toshiro Ono, Takushi Kurashige, Naoki Harada, Yuji Noguchi, Takashi Saika, Norio Niikawa, Motoi Aoe, Shinichiro Nakamura, Toshihiro Higashi, Akio Hiraki, Hisashi Wada, Hiromi Kumon, Lloyd J. Old, and Eiichi Nakayama PMCID: PMC30645 From the Cover:
Ligand-independent assembly of recombinant human CD1 by using
oxidative refolding chromatography Myriam M. Altamirano, Adrian Woolfson, Alena Donda, Abdijapar Shamshiev, Luis Briseño-Roa, Nicholas W. Foster, Dmitry B. Veprintsev, Gennaro De Libero, Alan R. Fersht, and César Milstein PMCID: PMC30646 From the Cover:
Human CD1d–glycolipid tetramers generated by in vitro oxidative refolding chromatography Anastasios Karadimitris, Stephan Gadola, Myriam Altamirano, Dave Brown, Adrian Woolfson, Paul Klenerman, Ji-Li Chen, Yasuhiko Koezuka, Irene A. G. Roberts, David A. Price, Geoff Dusheiko, César Milstein, Alan Fersht, Lucio Luzzatto, and Vincenzo Cerundolo PMCID: PMC30647 Intralymphatic immunization enhances DNA vaccination Kevin J. Maloy, Iris Erdmann, Veronique Basch, Sophie Sierro, Thomas A. Kramps, Rolf M. Zinkernagel, Stefan Oehen, and Thomas M. Kündig PMCID: PMC30648 Site-specific mutations in the mature form of human IL-18 with
enhanced biological activity and decreased neutralization by
IL-18 binding protein Soo-Hyun M. Kim, Tania Azam, Do-Young Yoon, Leonid L. Reznikov, Daniela Novick, Menachem Rubinstein, and Charles A. Dinarello PMCID: PMC30649 Peyer's patches are required for oral tolerance to proteins Kohtaro Fujihashi, Taeko Dohi, Paul D. Rennert, Masafumi Yamamoto, Toshiya Koga, Hiroshi Kiyono, and Jerry R. McGhee PMCID: PMC30650 Testicular FasL is expressed by sperm cells Alessio D'Alessio, Anna Riccioli, Paola Lauretti, Fabrizio Padula, Barbara Muciaccia, Paola De Cesaris, Antonio Filippini, Shigekazu Nagata, and Elio Ziparo PMCID: PMC30651 Medical Sciences Targeted inhibition of calcineurin attenuates cardiac hypertrophy
in vivo Leon J. De Windt, Hae W. Lim, Orlando F. Bueno, Qiangrong Liang, Ulrike Delling, Julian C. Braz, Betty J. Glascock, Thomas F. Kimball, Federica del Monte, Roger J. Hajjar, and Jeffery D. Molkentin PMCID: PMC30652 Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits
cardiac hypertrophy in vivo Beverly A. Rothermel, Timothy A. McKinsey, Rick B. Vega, Rebekka L. Nicol, Pradeep Mammen, John Yang, Christopher L. Antos, John M. Shelton, Rhonda Bassel-Duby, Eric N. Olson, and R. Sanders Williams PMCID: PMC30653 Declining brain activity in cognitively normal apolipoprotein E
![[var epsilon]](corehtml/pmc/pmcents/epsiv.gif) 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's
disease Eric M. Reiman, Richard J. Caselli, Kewei Chen, Gene E. Alexander, Daniel Bandy, and Jennifer Frost PMCID: PMC30654 The pattern of gene expression in human CD15+ myeloid
progenitor cells Sanggyu Lee, Guolin Zhou, Terry Clark, Jianjun Chen, Janet D. Rowley, and San Ming Wang PMCID: PMC30655 FHIT gene therapy prevents tumor development in
Fhit-deficient mice Kristoffel R. Dumon, Hideshi Ishii, Louise Y. Y. Fong, Nicola Zanesi, Vincenzo Fidanza, Rita Mancini, Andrea Vecchione, Raffaele Baffa, Francesco Trapasso, Matthew J. During, Kay Huebner, and Carlo M. Croce PMCID: PMC30656 Heparin and cancer revisited: Mechanistic connections involving
platelets, P-selectin, carcinoma mucins, and tumor metastasis Lubor Borsig, Richard Wong, James Feramisco, David R. Nadeau, Nissi M. Varki, and Ajit Varki PMCID: PMC30657 Acceleration of atherogenesis by COX-1-dependent prostanoid
formation in low density lipoprotein receptor knockout mice Domenico Praticò, Cyrus Tillmann, Zhi-Bing Zhang, Hongwei Li, and Garret A. FitzGerald PMCID: PMC30658 Poly(ADP-ribose) polymerase-1 is required for efficient
HIV-1 integration Hyo Chol Ha, Krishna Juluri, Yan Zhou, Steve Leung, Monika Hermankova, and Solomon H. Snyder PMCID: PMC30659 The nuclear receptor PXR is a lithocholic acid sensor that
protects against liver toxicity Jeff L. Staudinger, Bryan Goodwin, Stacey A. Jones, Diane Hawkins-Brown, Kathleen I. MacKenzie, Anne LaTour, Yaping Liu, Curtis D. Klaassen, Kathleen K. Brown, John Reinhard, Timothy M. Willson, Beverly H. Koller, and Steven A. Kliewer PMCID: PMC30660 An essential role for nuclear receptors SXR/PXR in
detoxification of cholestatic bile acids Wen Xie, Anna Radominska-Pandya, Yanhong Shi, Cynthia M. Simon, Michael C. Nelson, Erwin S. Ong, David J. Waxman, and Ronald M. Evans PMCID: PMC30661 Telomere dysfunction alters the chemotherapeutic profile of
transformed cells Kee-Ho Lee, K. Lenhard Rudolph, Yeun-Jin Ju, Roger A. Greenberg, Linda Cannizzaro, Lynda Chin, Sarah R. Weiler, and Ronald A. DePinho PMCID: PMC30662 Inherited susceptibility to uterine leiomyomas and renal
cell cancer Virpi Launonen, Outi Vierimaa, Maija Kiuru, Jorma Isola, Stina Roth, Eero Pukkala, Pertti Sistonen, Riitta Herva, and Lauri A. Aaltonen PMCID: PMC30663 Müllerian Inhibiting Substance lowers testosterone in
luteinizing hormone-stimulated rodents Alexander M. Trbovich, Patrick M. Sluss, V. Matt Laurich, Francis H. O'Neill, David T. MacLaughlin, Patricia K. Donahoe, and Jose Teixeira PMCID: PMC30664 Vaccination for protection of retinal ganglion cells against
death from glutamate cytotoxicity and ocular hypertension:
Implications for glaucoma Hadas Schori, Jonathan Kipnis, Eti Yoles, Elizabeth WoldeMussie, Guadalupe Ruiz, Larry A. Wheeler, and Michal Schwartz PMCID: PMC30665 From the Cover:
Potency of Michael reaction acceptors as inducers of enzymes
that protect against carcinogenesis depends on their reactivity
with sulfhydryl groups Albena T. Dinkova-Kostova, Michael A. Massiah, Richard E. Bozak, Ronald J. Hicks, and Paul Talalay PMCID: PMC30666 From the Cover:
Sensitivity to carcinogenesis is increased and
chemoprotective efficacy of enzyme inducers is lost in
nrf2 transcription factor-deficient mice Minerva Ramos-Gomez, Mi-Kyoung Kwak, Patrick M. Dolan, Ken Itoh, Masayuki Yamamoto, Paul Talalay, and Thomas W. Kensler PMCID: PMC30667 The dependence receptor DCC (deleted in colorectal cancer)
defines an alternative mechanism for caspase activation Christelle Forcet, Xin Ye, Laure Granger, Véronique Corset, Hwain Shin, Dale E. Bredesen, and Patrick Mehlen PMCID: PMC30668 Unbalanced expression of the different subunits of elongation
factor 1 in diabetic skeletal muscle Christine Reynet and C. Ronald Kahn PMCID: PMC30669 Preselective gene therapy for Fabry disease Gangjian Qin, Toshihiro Takenaka, Kimberly Telsch, Leslie Kelley, Tazuko Howard, Thierry Levade, Robert Deans, Bruce H. Howard, Harry L. Malech, Roscoe O. Brady, and Jeffrey A. Medin PMCID: PMC30670 A role for intracellular pH in membrane IgM-mediated cell death
of human B lymphomas Radu Marches, Ellen S. Vitetta, and Jonathan W. Uhr PMCID: PMC30671 Patients with Alzheimer's disease have reduced activities in
midlife compared with healthy control-group members Robert P. Friedland, Thomas Fritsch, Kathleen A. Smyth, Elisabeth Koss, Alan J. Lerner, Chien Hsiun Chen, Grace J. Petot, and Sara M. Debanne PMCID: PMC30672 Microbiology INAUGURAL ARTICLE by a Recently Elected Academy Member: Appetite of an epiphyte: Quantitative monitoring of bacterial
sugar consumption in the phyllosphere Johan H. J. Leveau and Steven E. Lindow PMCID: PMC30673 Heterogeneous transcription of an indoleacetic acid biosynthetic
gene in Erwinia herbicola on plant surfaces M. T. Brandl, B. Quiñones, and S. E. Lindow PMCID: PMC30674 Complete genomic sequence of Pasteurella
multocida,Pm70 Barbara J. May, Qing Zhang, Ling Ling Li, Michael L. Paustian, Thomas S. Whittam, and Vivek Kapur PMCID: PMC30675 Herpesviruses use bidirectional fast-axonal transport to spread
in sensory neurons Gregory A. Smith, Steven P. Gross, and Lynn W. Enquist PMCID: PMC30676 The targeting pathway of Escherichia coli
presecretory and integral membrane proteins is specified by the
hydrophobicity of the targeting signal Hin C. Lee and Harris D. Bernstein PMCID: PMC30677 Neurobiology Down-regulation of dendritic spine and glutamic acid
decarboxylase 67 expressions in the reelin haploinsufficient
heterozygous reeler mouse Wen Sheng Liu, Christine Pesold, Miguel A. Rodriguez, Giovanni Carboni, James Auta, Pascal Lacor, John Larson, Brian G. Condie, Alessandro Guidotti, and Erminio Costa PMCID: PMC30678 Glutamic acid decarboxylase and glutamate receptor changes during
tolerance and dependence to benzodiazepines Emanuela Izzo, James Auta, Francesco Impagnatiello, Christine Pesold, Alessandro Guidotti, and Erminio Costa PMCID: PMC30679 Synaptic and extrasynaptic γ-aminobutyric acid type A receptor
clusters in rat hippocampal cultures during development Alessandra L. Scotti and Harald Reuter PMCID: PMC30680 Neural fate of seen and unseen faces in visuospatial neglect: A
combined event-related functional MRI and event-related
potential study Patrik Vuilleumier, Noam Sagiv, Eliot Hazeltine, Russel A. Poldrack, Diane Swick, Robert D. Rafal, and John D. E. Gabrieli PMCID: PMC30681 α10: A determinant of nicotinic cholinergic receptor function
in mammalian vestibular and cochlear mechanosensory hair cells A. Belén Elgoyhen, Douglas E. Vetter, Eleonora Katz, Carla V. Rothlin, Stephen F. Heinemann, and Jim Boulter PMCID: PMC30682 Plasticity of the cochleotopic (frequency) map in specialized and
nonspecialized auditory cortices Masashi Sakai and Nobuo Suga PMCID: PMC30683 Spontaneous corticospinal axonal plasticity and functional
recovery after adult central nervous system injury Norbert Weidner, Arvin Ner, Nima Salimi, and Mark H. Tuszynski PMCID: PMC30684 An N-methyl-d-aspartate receptor
channel blocker with neuroprotective activity Kwok-Keung Tai, Sylvie E. Blondelle, John M. Ostresh, Richard A. Houghten, and Mauricio Montal PMCID: PMC30685 From the Cover:
Estrogen increases synaptic connectivity between single
presynaptic inputs and multiple postsynaptic CA1 pyramidal cells:
A serial electron-microscopic study Maya Yankova, Sharron A. Hart, and Catherine S. Woolley PMCID: PMC30686 Inactivating one hippocampus impairs avoidance of a stable
room-defined place during dissociation of arena cues from room
cues by rotation of the arena J. M. Cimadevilla, M. Wesierska, A. A. Fenton, and J. Bures PMCID: PMC30687 Substratal idiothetic navigation of rats is impaired by removal
or devaluation of extramaze and intramaze cues A. Stuchlik, A. A. Fenton, and J. Bures PMCID: PMC30688 CA1-specific N-methyl-d-aspartate
receptor knockout mice are deficient in solving a nonspatial transverse patterning task Laure Rondi-Reig, Megan Libbey, Howard Eichenbaum, and Susumu Tonegawa PMCID: PMC30689 Mice transgenically overexpressing sulfonylurea receptor 1 in
forebrain resist seizure induction and excitotoxic neuron death Catalina Hernández-Sánchez, Anthony S. Basile, Irina Fedorova, Hiroshi Arima, Bethel Stannard, Ana M. Fernandez, Yutaka Ito, and Derek LeRoith PMCID: PMC30690 Activation of Trk neurotrophin receptors in the absence
of neurotrophins Francis S. Lee and Moses V. Chao PMCID: PMC30691 Insulin promotes rapid delivery of
N-methyl-d- aspartate receptors to the
cell surface by exocytosis Vytenis A. Skeberdis, Jian-yu Lan, Xin Zheng, R. Suzanne Zukin, and Michael V. L. Bennett PMCID: PMC30692 A method for soluble overexpression of the α7 nicotinic
acetylcholine receptor extracellular domain Markus Fischer, Pierre-Jean Corringer, Karin Schott, Adelbert Bacher, and Jean-Pierre Changeux PMCID: PMC30693 Genetically altered AMPA-type glutamate receptor kinetics in
interneurons disrupt long-range synchrony of gamma oscillation Elke C. Fuchs, Helen Doheny, Howard Faulkner, Antonio Caputi, Roger D. Traub, Andrea Bibbig, Nancy Kopell, Miles A. Whittington, and Hannah Monyer PMCID: PMC30694 Most central nervous system D2 dopamine receptors are coupled to
their effectors by Go Meisheng Jiang, Karsten Spicher, Guylain Boulay, Ying Wang, and Lutz Birnbaumer PMCID: PMC30695 Pharmacology Nitric oxide-induced cytostasis and cell cycle arrest of a human
breast cancer cell line (MDA-MB-231): Potential role of cyclin D1 Shehla Pervin, Rajan Singh, and Gautam Chaudhuri PMCID: PMC30696 Testosterone inhibits early atherogenesis by conversion to
estradiol: Critical role of aromatase Lauren Nathan, Weibin Shi, Hillary Dinh, Tapan K. Mukherjee, Xuping Wang, Aldons J. Lusis, and Gautam Chaudhuri PMCID: PMC30697 Physiology A conditional probability analysis of cystic fibrosis
transmembrane conductance regulator gating indicates that ATP has
multiple effects during the gating cycle Daniel J. Hennager, Mutsuhiro Ikuma, Toshinori Hoshi, and Michael J. Welsh PMCID: PMC30698 Competitive regulation of CaT-like-mediated Ca2+
entry by protein kinase C and calmodulin Barbara A. Niemeyer, Christiane Bergs, Ulrich Wissenbach, Veit Flockerzi, and Claudia Trost PMCID: PMC30699 Single point mutations affect fatty acid block of human
myocardial sodium channel α subunit Na+ channels Yong-Fu Xiao, Qingen Ke, Sho-Ya Wang, Klaus Auktor, Yinke Yang, Ging Kuo Wang, James P. Morgan, and Alexander Leaf PMCID: PMC30700 Plant Biology In vitro assembly of phytochrome B apoprotein with
synthetic analogs of the phytochrome chromophore Hiroko Hanzawa, Katsuhiko Inomata, Hideki Kinoshita, Takashi Kakiuchi, Krishanthi Padmarani Jayasundera, Daisuke Sawamoto, Atsuko Ohta, Kenko Uchida, Keishiro Wada, and Masaki Furuya PMCID: PMC30701 Population Biology Live attenuated HIV vaccines: Predicting the tradeoff between
efficacy and safety S. M. Blower, K. Koelle, D. E. Kirschner, and J. Mills PMCID: PMC30702 Corrections Proc Natl Acad Sci U S A. 2001 March 13; 98(6): 3624. Published online 2001 March 6. doi: 10.1073/pnas.081087998.PMCID: PMC55937 Corrects: Randall M. Story, et al. Crystal structure of a DEAD box protein from the hyperthermophile
Methanococcus jannaschii. Proc Natl Acad Sci U S A. 2001 February 13; 98(4): 1465–1470. Proc Natl Acad Sci U S A. 2001 March 13; 98(6): 3624. Published online 2001 March 6. doi: 10.1073/pnas.081073598.PMCID: PMC55938 Corrects: Beat M. Jucker, et al. Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR. Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6880–6884. |
