| | This journal provides immediate access to some articles. Commentaries Kinetochore reproduction theory may explain rapid
chromosome evolution Laurie R. Godfrey and Judith C. Masters PMCID: PMC34032 Switching on and off with RNA Shoshy Altuvia and E. Gerhart H. Wagner PMCID: PMC34033 Amiloride-sensitive sodium channels contribute to the woes of
the flu William B. Guggino and Sandra E. Guggino PMCID: PMC34034 Simian virus 40 and the human mesothelium George Klein PMCID: PMC34035 Skeletal muscle sodium current is reduced in hypokalemic
periodic paralysis Robert L. Ruff PMCID: PMC34036 Physical Sciences Applied Mathematics Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizations Mei-Ling Ting Lee, Frank C. Kuo, G. A. Whitmore, and Jeffrey Sklar PMCID: PMC27599 “Coarse” stability and bifurcation analysis using time-steppers: A reaction-diffusion example Constantinos Theodoropoulos, Yue-Hong Qian, and Ioannis G. Kevrekidis PMCID: PMC27601 Self-similar intermediate asymptotics for a degenerate parabolic filtration-absorption equation G. I. Barenblatt, M. Bertsch, A. E. Chertock, and V. M. Prostokishin PMCID: PMC27602 Chemistry Dynamical principles in biological processes: A model of charge migration in proteins and DNA E. W. Schlag, D.-Y. Yang, S.-Y. Sheu, H. L. Selzle, S. H. Lin, and P. M. Rentzepis PMCID: PMC27603 Scanning electrochemical microscopy of living cells: Different redox activities of nonmetastatic and metastatic human breast cells Biao Liu, Susan A. Rotenberg, and Michael V. Mirkin PMCID: PMC27604 Gel catalysts that switch on and off Guoqiang Wang, Kenichi Kuroda, Takashi Enoki, Alexander Grosberg, Satoru Masamune, Taro Oya, Yukikazu Takeoka, and Toyoichi Tanaka PMCID: PMC27606 Photochemically induced nuclear spin polarization in reaction
centers of photosystem II observed by 13C-solid-state
NMR reveals a strongly asymmetric electronic structure of the P680.+
primary donor chlorophyll Jörg Matysik, Alia, Peter Gast, Hans J. van Gorkom, Arnold J. Hoff, and Huub J. M. de Groot PMCID: PMC27608 Engineering The mechanical properties of Saccharomyces cerevisiae Alexander E. Smith, Zhibing Zhang, Colin R. Thomas, Kennith E. Moxham, and Anton P. J. Middelberg PMCID: PMC27610 Geophysics Global warming in the twenty-first century: An alternative scenario James Hansen, Makiko Sato, Reto Ruedy, Andrew Lacis, and Valdar Oinas PMCID: PMC27611 Mathematics Free entropy and property T factors Liming Ge and Junhao Shen PMCID: PMC27613 Physics From the Cover:
Building a dictionary for genomes: Identification of presumptive regulatory sites by statistical analysis Harmen J. Bussemaker, Hao Li, and Eric D. Siggia PMCID: PMC27717 Biological Sciences Agricultural Sciences INAUGURAL ARTICLE by a Recently Elected Academy Member: The MITE family Heartbreaker ( Hbr): Molecular markers in maize Alexandra M. Casa, Cory Brouwer, Alexander Nagel, Lianjiang Wang, Qiang Zhang, Stephen Kresovich, and Susan R. Wessler PMCID: PMC27704 Applied Biological Sciences The mechanical properties of Saccharomyces cerevisiae Alexander E. Smith, Zhibing Zhang, Colin R. Thomas, Kennith E. Moxham, and Anton P. J. Middelberg PMCID: PMC27610 Biochemistry A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage Stéphane Vispé, Tetsu M. C. Yung, Janelle Ritchot, Hiroaki Serizawa, and Masahiko S. Satoh PMCID: PMC27615 Structural evidence for a programmed general base in the active site of a catalytic antibody Béatrice Golinelli-Pimpaneau, Olivier Gonçalves, Thierry Dintinger, Dominique Blanchard, Marcel Knossow, and Charles Tellier PMCID: PMC27617 Identification of a renal-specific oxido-reductase in newborn diabetic mice Qiwei Yang, Bharat Dixit, Jun Wada, Yufeng Tian, Elisabeth I. Wallner, Satish K. Srivastva, and Yashpal S. Kanwar PMCID: PMC27618 Inhibition of the ubiquitin-proteasome system in Alzheimer's disease Y. Amy Lam, Cecile M. Pickart, Andrew Alban, Michael Landon, Craig Jamieson, Robert Ramage, R. John Mayer, and Robert Layfield PMCID: PMC27620 Designed protein tetramer zipped together with a hydrophobic Alzheimer homology: A structural clue to amyloid assembly Daniel E. Otzen, Ole Kristensen, and Mikael Oliveberg PMCID: PMC27622 Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain Sylviane Robineau, Marc Chabre, and Bruno Antonny PMCID: PMC27624 From the Cover:
A trans-acting RNA as a control switch in Escherichia coli: DsrA modulates function by forming alternative structures Richard A. Lease and Marlene Belfort PMCID: PMC27626 Directed evolution of a (βα)8-barrel enzyme to catalyze related reactions in two different metabolic pathways Catharina Jürgens, Alexander Strom, Dennis Wegener, Stefan Hettwer, Matthias Wilmanns, and Reinhard Sterner PMCID: PMC27628 Hexose permeation pathways in Plasmodium falciparum-infected erythrocytes Charles J. Woodrow, Richard J. Burchmore, and Sanjeev Krishna PMCID: PMC27630 The importance of reactant positioning in enzyme catalysis: A hybrid quantum mechanics/molecular mechanics study of a haloalkane dehalogenase Edmond Y. Lau, Kalju Kahn, Paul A. Bash, and Thomas C. Bruice PMCID: PMC27632 Relative role of heme nitrosylation and β-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation Mark T. Gladwin, Frederick P. Ognibene, Lewis K. Pannell, James S. Nichols, Margaret E. Pease-Fye, James H. Shelhamer, and Alan N. Schechter PMCID: PMC27634 Molecular basis of lutropin recognition by the mannose/GalNAc-4-SO4 receptor Daniel S. Roseman and Jacques U. Baenziger PMCID: PMC27635 Biophysics A meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53 J. Noolandi, T. S. Davison, A. R. Völkel, X.-F. Nie, C. Kay, and C. H. Arrowsmith PMCID: PMC27637 Solvent dependence of dynamic transitions in protein solutions Valerie Réat, Rachel Dunn, Michel Ferrand, John L. Finney, Roy M. Daniel, and Jeremy C. Smith PMCID: PMC27638 Using O2 to probe membrane immersion depth by 19F NMR R. Scott Prosser, Paul A. Luchette, and Philip W. Westerman PMCID: PMC27640 Unbinding forces of single antibody-antigen complexes correlate with their thermal dissociation rates Falk Schwesinger, Robert Ros, Torsten Strunz, Dario Anselmetti, Hans-Joachim Güntherodt, Annemarie Honegger, Lutz Jermutus, Louis Tiefenauer, and Andreas Plückthun PMCID: PMC27642 Statistical significance of protein structure prediction by threading Leonid A. Mirny, Alexey V. Finkelstein, and Eugene I. Shakhnovich PMCID: PMC27644 Cell Biology Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs Jing Yang, Jie Wu, M. Anna Kowalska, Ashutosh Dalvi, Nicolas Prevost, Peter J. O'Brien, David Manning, Mortimer Poncz, Irwin Lucki, Julie A. Blendy, and Lawrence F. Brass PMCID: PMC27645 Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity Evelyn W. Wang, Benedikt M. Kessler, Anna Borodovsky, Benjamin F. Cravatt, Matthew Bogyo, Hidde L. Ploegh, and Rickard Glas PMCID: PMC27648 Calcium-triggered acrosomal exocytosis in human spermatozoa requires the coordinated activation of Rab3A and N-ethylmaleimide-sensitive factor M. Michaut, C. N. Tomes, G. De Blas, R. Yunes, and L. S. Mayorga PMCID: PMC27650 The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle Stefan Duensing, Lily Y. Lee, Anette Duensing, John Basile, Siribang-on Piboonniyom, Sonia Gonzalez, Christopher P. Crum, and Karl Münger PMCID: PMC27652 A role for α- and β-catenins in bacterial uptake Marc Lecuit, Reini Hurme, Javier Pizarro-Cerdá, Hélène Ohayon, Benjamin Geiger, and Pascale Cossart PMCID: PMC27655 Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation Victoria M. Richon, Todd W. Sandhoff, Richard A. Rifkind, and Paul A. Marks PMCID: PMC27656 How well can an amoeba climb? Yoshio Fukui, Taro Q. P. Uyeda, Chikako Kitayama, and Shinya Inoué PMCID: PMC27658 Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1 Patrick Henriet, Zhi-Duan Zhong, Peter C. Brooks, Kenneth I. Weinberg, and Yves A. DeClerck PMCID: PMC27660 Developmental Biology Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell Joel Smith, Ena Ladi, Margot Mayer-Pröschel, and Mark Noble PMCID: PMC27662 A role for Timeless in epithelial morphogenesis during kidney development Zhixing Li, Robert O. Stuart, Jizeng Qiao, Anna Pavlova, Kevin T. Bush, Martin Pohl, Hiroyuki Sakurai, and Sanjay K. Nigam PMCID: PMC27664 Conservation of early odontogenic signaling pathways in Aves YiPing Chen, Yanding Zhang, Ting-Xing Jiang, Amanda J. Barlow, Tara R. St. Amand, Yueping Hu, Shaun Heaney, Philippa Francis-West, Cheng-Ming Chuong, and Richard Maas PMCID: PMC27667 Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development Karen J. Dunn, Bart O. Williams, Yi Li, and William J. Pavan PMCID: PMC34553 Evolution Functional and physiological consequences of genetic variation at phosphoglucose isomerase: Heat shock protein expression is related to enzyme genotype in a montane beetle Elizabeth P. Dahlhoff and Nathan E. Rank PMCID: PMC27685 Anthropoid humeri from the late Eocene of Egypt Erik R. Seiffert, Elwyn L. Simons, and John G. Fleagle PMCID: PMC27687 Novel folded protein domains generated by combinatorial shuffling of polypeptide segments Lutz Riechmann and Greg Winter PMCID: PMC27691 Multiple benefits of multiple mating in guppies J. P. Evans and A. E. Magurran PMCID: PMC27698 Genetics Functions of the DNA damage response pathway target Ho endonuclease of yeast for degradation via the ubiquitin-26S proteasome system Ludmila Kaplun, Yelena Ivantsiv, Daniel Kornitzer, and Dina Raveh PMCID: PMC27699 INAUGURAL ARTICLE by a Recently Elected Academy Member: The MITE family Heartbreaker ( Hbr): Molecular markers in maize Alexandra M. Casa, Cory Brouwer, Alexander Nagel, Lianjiang Wang, Qiang Zhang, Stephen Kresovich, and Susan R. Wessler PMCID: PMC27704 Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/ DiGeorge syndrome region Anne Puech, Bruno Saint-Jore, Sandra Merscher, Robert G. Russell, Dorra Cherif, Howard Sirotkin, Hui Xu, Stephen Factor, Raju Kucherlapati, and Arthur I. Skoultchi PMCID: PMC27709 From the Cover:
Building a dictionary for genomes: Identification of presumptive regulatory sites by statistical analysis Harmen J. Bussemaker, Hao Li, and Eric D. Siggia PMCID: PMC27717 Singular value decomposition for genome-wide expression data processing and modeling Orly Alter, Patrick O. Brown, and David Botstein PMCID: PMC27718 TOM1, an Arabidopsis gene required for efficient multiplication of a tobamovirus, encodes a putative transmembrane protein Takuya Yamanaka, Takehiro Ohta, Miki Takahashi, Tetsuo Meshi, Renate Schmidt, Caroline Dean, Satoshi Naito, and Masayuki Ishikawa PMCID: PMC27728 Immunology INAUGURAL ARTICLE by a Recently Elected Academy Member: Immunoassays with rolling circle DNA amplification: A versatile platform for ultrasensitive antigen detection Barry Schweitzer, Steven Wiltshire, Jeremy Lambert, Shawn O'Malley, Kari Kukanskis, Zhengrong Zhu, Stephen F. Kingsmore, Paul M. Lizardi, and David C. Ward PMCID: PMC27732 A Stat3-interacting protein (StIP1) regulates cytokine signal transduction Robert G. Collum, Siska Brutsaert, Gladys Lee, and Christian Schindler PMCID: PMC27739 Virus neutralization by germ-line vs. hypermutated antibodies Ulrich Kalinke, Annette Oxenius, Constantino López-Macías, Rolf M. Zinkernagel, and Hans Hengartner PMCID: PMC27744 Retinoid-related orphan receptor γ (RORγ) is essential for
lymphoid organogenesis and controls apoptosis
during thymopoiesis Shogo Kurebayashi, Eiichiro Ueda, Morito Sakaue, Dhavalkumar D. Patel, Alex Medvedev, Feng Zhang, and Anton M. Jetten PMCID: PMC27750 A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation Kenneth G. Johnson, Shannon K. Bromley, Michael L. Dustin, and Matthew L. Thomas PMCID: PMC27752 Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimulating factor Laure Dumoutier, Emiel Van Roost, Didier Colau, and Jean-Christophe Renauld PMCID: PMC27764 The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte–antigen-presenting cell interface Christoph Wülfing, Angela Bauch, Gerald R. Crabtree, and Mark M. Davis PMCID: PMC27768 Structural requirements for antigen presentation by mouse CD1 Nicolas Burdin, Laurent Brossay, Massimo Degano, Hiroshi Iijima, Ming Gui, Ian A. Wilson, and Mitchell Kronenberg PMCID: PMC27774 A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling Andrew Bowie, Endre Kiss-Toth, Julian A. Symons, Geoffrey L. Smith, Steven K. Dower, and Luke A. J. O'Neill PMCID: PMC27775 Medical Sciences Genetic influence on the structural variations of the abnormal prion protein Piero Parchi, Wenquan Zou, Wen Wang, Paul Brown, Sabina Capellari, Bernardino Ghetti, Nicolas Kopp, Walter J. Schulz-Schaeffer, Hans A. Kretzschmar, Mark W. Head, James W. Ironside, Pierluigi Gambetti, and Shu G. Chen PMCID: PMC27779 Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARα and PLZF-RARα oncoproteins Eduardo M. Rego, Li-Zhen He, Raymond P. Warrell, Jr., Zhu-Gang Wang, and Pier Paolo Pandolfi PMCID: PMC27786 Diagnostic ultrasound activation of contrast agent gas bodies induces capillary rupture in mice Douglas L. Miller and Jawaid Quddus PMCID: PMC27793 Androgen-induced proliferative quiescence in prostate cancer cells: The role of AS3 as its mediator Peter Geck, Maricel V. Maffini, Jozsef Szelei, Carlos Sonnenschein, and Ana M. Soto PMCID: PMC27796 Genetic footprinting with mariner-based transposition in Pseudomonas aeruginosa Sandy M. Wong and John J. Mekalanos PMCID: PMC27802 Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits Ken Shinmura, Xian-Liang Tang, Yang Wang, Yu-Ting Xuan, Si-Qi Liu, Hitoshi Takano, Aruni Bhatnagar, and Roberto Bolli PMCID: PMC27805 Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase Lucas Liaudet, Francisco Garcia Soriano, Éva Szabó, László Virág, Jon G. Mabley, Andrew L. Salzman, and Csaba Szabó PMCID: PMC27808 Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas Izidore S. Lossos, Ash A. Alizadeh, Michael B. Eisen, Wing C. Chan, Patrick O. Brown, David Botstein, Louis M. Staudt, and Ronald Levy PMCID: PMC27813 From the Cover:
Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity Maurizio Bocchetta, Ilaria Di Resta, Amy Powers, Raoul Fresco, Alessandra Tosolini, Joseph R. Testa, Harvey I. Pass, Paola Rizzo, and Michele Carbone PMCID: PMC27818 Microbiology Altered expression of the ToxR-regulated porins OmpU and OmpT diminishes Vibrio cholerae bile resistance, virulence factor expression, and intestinal colonization Daniele Provenzano and Karl E. Klose PMCID: PMC27820 Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system Tomoko Kubori, Anand Sukhan, Shin-Ichi Aizawa, and Jorge E. Galán PMCID: PMC27824 From the Cover:
Establishment of an animal–bacterial association: Recruiting symbiotic vibrios from the environment Spencer V. Nyholm, Eric V. Stabb, Edward G. Ruby, and Margaret J. McFall-Ngai PMCID: PMC27829 Neurobiology Insulin-like growth factor 1 regulates developing brain glucose metabolism Clara M. Cheng, Rickey R. Reinhardt, Wei-Hua Lee, George Joncas, Sonya C. Patel, and Carolyn A. Bondy PMCID: PMC27834 Vascular endothelial growth factor: Direct neuroprotective effect in in vitro ischemia Kun Lin Jin, Xiao Ou Mao, and David A. Greenberg PMCID: PMC27841 Species-barrier-independent prion replication in apparently resistant species Andrew F. Hill, Susan Joiner, Jackie Linehan, Melanie Desbruslais, Peter L. Lantos, and John Collinge PMCID: PMC27848 Cyclin-dependent kinases as a therapeutic target for stroke Hitoshi Osuga, Sachiko Osuga, Fuhu Wang, Raouf Fetni, Matthew J. Hogan, Ruth S. Slack, Antoine M. Hakim, Joh-E Ikeda, and David S. Park PMCID: PMC27851 Connexin expression in electrically coupled postnatal rat brain neurons Laurent Venance, Andrei Rozov, Maria Blatow, Nail Burnashev, Dirk Feldmeyer, and Hannah Monyer PMCID: PMC27858 Diversity and phylogeny of gephyrin: Tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins Markus Ramming, Stefan Kins, Nikos Werner, Achim Hermann, Heinrich Betz, and Joachim Kirsch PMCID: PMC27865 Pharmacology Nociception in cyclooxygenase isozyme-deficient mice Leslie R. Ballou, Regina M. Botting, Sarita Goorha, Jianyi Zhang, and John R. Vane PMCID: PMC27868 Constitutive activation of tethered-peptide/ corticotropin-releasing factor receptor chimeras Søren Møller Nielsen, Lisa Z. Nielsen, Siv A. Hjorth, Marilyn H. Perrin, and Wylie W. Vale PMCID: PMC27874 Physiology From the Cover:
Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia K. Kunzelmann, A. H. Beesley, N. J. King, G. Karupiah, J. A. Young, and D. I. Cook PMCID: PMC27875 Growth differentiation factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin E2/EP2 receptor pathway Julia A. Elvin, Changning Yan, and Martin M. Matzuk PMCID: PMC27877 Corrections Proc Natl Acad Sci U S A. 2000 August 29; 97(18): 10294. Published online 2000 August 15. PMCID: PMC56076 Corrects: Yu Li, et al. Bepridil opens the regulatory N-terminal lobe of cardiac troponin C. Proc Natl Acad Sci U S A. 2000 May 9; 97(10): 5140–5145. Proc Natl Acad Sci U S A. 2000 August 29; 97(18): 10294. PMCID: PMC56077 Corrects: Ching-Cheng Chen, et al. Paternal monoallelic expression of the paired immunoglobulin-like receptors PIR-A and PIR-B. Proc Natl Acad Sci U S A. 1999 June 8; 96(12): 6868–6872. |
