| | This journal provides immediate access to some articles. Commentary Models of treatment effects when responses are heterogeneous Robert A. Moffitt PMCID: PMC33579 Physical Sciences Chemistry Self-assembly of chlorophenols in water Ewa Rogalska, Marek Rogalski, Tadeusz Gulik-Krzywicki, Annette Gulik, and Christophe Chipot PMCID: PMC21956 Catalysis of peptide dissociation from class II MHC-peptide complexes Lutz Schmitt, Johannes R. Kratz, Mark M. Davis, and Harden M. McConnell PMCID: PMC21957 Cytochrome b562 folding triggered by electron transfer: Approaching the speed limit for formation of a four-helix-bundle protein Pernilla Wittung-Stafshede, Jennifer C. Lee, Jay R. Winkler, and Harry B. Gray PMCID: PMC21958 Accurate quantitation of protein expression and site-specific phosphorylation Y. Oda, K. Huang, F. R. Cross, D. Cowburn, and B. T. Chait PMCID: PMC21959 The force exerted by a molecular motor Michael E. Fisher and Anatoly B. Kolomeisky PMCID: PMC21960 Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct Hui Mao, Nathalie C. Schnetz-Boutaud, Jason P. Weisenseel, Lawrence J. Marnett, and Michael P. Stone PMCID: PMC21963 Engineering Vibro-acoustography: An imaging modality based on ultrasound-stimulated acoustic emission Mostafa Fatemi and James F. Greenleaf PMCID: PMC21961 Biological Sciences Biochemistry A small nucleolar RNA:ribozyme hybrid cleaves a nucleolar RNA target in vivo with near-perfect efficiency Dmitry A. Samarsky, Gerardo Ferbeyre, Edouard Bertrand, Robert H. Singer, Robert Cedergren, and Maurille J. Fournier PMCID: PMC21962 Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct Hui Mao, Nathalie C. Schnetz-Boutaud, Jason P. Weisenseel, Lawrence J. Marnett, and Michael P. Stone PMCID: PMC21963 The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein David Gilley and Elizabeth H. Blackburn PMCID: PMC21964 Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase Gustavo Leone, James DeGregori, Laszlo Jakoi, Jeanette G. Cook, and Joseph R. Nevins PMCID: PMC21965 Solution structure of a DNA decamer duplex containing the stable 3′ T ![[center dot]](corehtml/pmc/pmcents/middot.gif) G base pair of the pyrimidine(6–4)pyrimidone photoproduct [(6–4) adduct]: Implications for the highly specific 3′ T → C transition of the (6–4) adduct Joon-Hwa Lee, Geum-Sook Hwang, and Byong-Seok Choi PMCID: PMC21966 Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance Andy Ball, Robert Nielsen, Michael H. Gelb, and Bruce H. Robinson PMCID: PMC21967 Hemoglobin induction in mouse macrophages Limin Liu, Ming Zeng, and Jonathan S. Stamler PMCID: PMC21968 Feedback control of a master bacterial cell-cycle regulator Ibrahim J. Domian, Ann Reisenauer, and Lucy Shapiro PMCID: PMC21969 On the structure of endogenous ouabain Akira Kawamura, Jinsong Guo, Yasuhiro Itagaki, Charles Bell, Yi Wang, Garner T. Haupert, Jr., Sheila Magil, Rex T. Gallagher, Nina Berova, and Koji Nakanishi PMCID: PMC21970 CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene Masahiro Nitta, Sherry Ku, Chaline Brown, Arthur Y. Okamoto, and Bei Shan PMCID: PMC21971 Myosin light-chain kinase of smooth muscle stimulates myosin ATPase activity without phosphorylating myosin light chain Li-Hong Ye, Hiroko Kishi, Akio Nakamura, Tsuyoshi Okagaki, Takeshi Tanaka, Kazuhiro Oiwa, and Kazuhiro Kohama PMCID: PMC21972 Substrate binding and catalysis by ribonuclease P from cyanobacteria and Escherichia coli are affected differently by the 3′ terminal CCA in tRNA precursors Alberto Pascual and Agustín Vioque PMCID: PMC21973 Lon and Clp family proteases and chaperones share homologous substrate-recognition domains Catherine K. Smith, Tania A. Baker, and Robert T. Sauer PMCID: PMC21974 ZEB represses transcription through interaction with the corepressor CtBP Antonio A. Postigo and Douglas C. Dean PMCID: PMC21975 Declines in mitochondrial respiration during cardiac reperfusion: Age-dependent inactivation of α-ketoglutarate dehydrogenase David T. Lucas and Luke I. Szweda PMCID: PMC21976 Regulation of eukaryotic protein synthesis: Selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1 Young Woo Park, Jeffrey Wilusz, and Michael G. Katze PMCID: PMC21977 Biophysics The force exerted by a molecular motor Michael E. Fisher and Anatoly B. Kolomeisky PMCID: PMC21960 Nonlinear optical measurement of membrane potential around single molecules at selected cellular sites Gadi Peleg, Aaron Lewis, Michal Linial, and Leslie M. Loew PMCID: PMC21978 Direct observation of the anchoring process during the adsorption of fibrinogen on a solid surface by force-spectroscopy mode atomic force microscopy J. Hemmerlé, S. M. Altmann, M. Maaloum, J. K. H. Hörber, L. Heinrich, J.-C. Voegel, and P. Schaaf PMCID: PMC21979 Osmotic pressure contribution of albumin to colloidal interactions Mukta Singh-Zocchi, Anita Andreasen, and Giovanni Zocchi PMCID: PMC21980 Intermediates can accelerate protein folding Clemens Wagner and Thomas Kiefhaber PMCID: PMC21981 Cell Biology Clathrin-coated vesicles bearing GAIP possess GTPase-activating protein activity in vitro Thierry Fischer, Eric Elenko, J. Michael McCaffery, Luc DeVries, and Marilyn Gist Farquhar PMCID: PMC21982 Signaling via β1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro Alan Jian Zhu, Ingo Haase, and Fiona M. Watt PMCID: PMC21983 A dominant-negative pleiotrophin mutant introduced by homologous recombination leads to germ-cell apoptosis in male mice Nan Zhang, Hsiu-Jeng Yeh, Rong Zhong, Yue-Sheng Li, and Thomas F. Deuel PMCID: PMC21984 A Crm1p-independent nuclear export path for the mRNA-associated protein, Npl3p/Mtr13p Yan Liu, Wei Guo, Paola Y. Tartakoff, and Alan M. Tartakoff PMCID: PMC21985 Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays U. Alon, N. Barkai, D. A. Notterman, K. Gish, S. Ybarra, D. Mack, and A. J. Levine PMCID: PMC21986 Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: The role of ferritin Charareh Pourzand, Richard D. Watkin, Jonathan E. Brown, and Rex M. Tyrrell PMCID: PMC21987 Control of the low voltage-activated calcium channel of mouse sperm by egg ZP3 and by membrane hyperpolarization during capacitation Christophe Arnoult, Imrana G. Kazam, Pablo E. Visconti, Gregory S. Kopf, Michel Villaz, and Harvey M. Florman PMCID: PMC21988 Two distinct forms of the 64,000 Mr protein of the cleavage stimulation factor are expressed in mouse male germ cells A. Michelle Wallace, Brinda Dass, Stuart E. Ravnik, Vijay Tonk, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, and Clinton C. MacDonald PMCID: PMC21989 Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules Caroline Jolly, Yves Usson, and Richard I. Morimoto PMCID: PMC21990 Acute cholesterol depletion inhibits clathrin-coated pit budding Agathe Subtil, Ibragim Gaidarov, Keith Kobylarz, Michael A. Lampson, James H. Keen, and Timothy E. McGraw PMCID: PMC21991 Chromosome healing in mouse embryonic stem cells Carl N. Sprung, Gloria E. Reynolds, Maria Jasin, and John P. Murnane PMCID: PMC21992 Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits Henning Stahlberg, Eva Kutejová, Kitaru Suda, Bettina Wolpensinger, Ariel Lustig, Gottfried Schatz, Andreas Engel, and Carolyn K. Suzuki PMCID: PMC21993 Developmental Biology A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation Kazuya Shimizu and J. B. Gurdon PMCID: PMC21994 The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo Mattias Mannervik and Michael Levine PMCID: PMC21995 Activity regulation of Hox proteins, a mechanism for altering functional specificity in development and evolution Xuelin Li and William McGinnis PMCID: PMC21996 Ecology Phytoremediation of methylmercury pollution: merB expression in Arabidopsis thaliana confers resistance to organomercurials Scott P. Bizily, Clayton L. Rugh, Anne O. Summers, and Richard B. Meagher PMCID: PMC21997 Evolution Four intracellular genomes direct weevil biology: Nuclear, mitochondrial, principal endosymbiont, and Wolbachia Abdelaziz Heddi, Anne-Marie Grenier, Chaqué Khatchadourian, Hubert Charles, and Paul Nardon PMCID: PMC21998 Molecular genetics of ecological diversification: Duplication and rapid evolution of toxin genes of the venomous gastropod Conus Thomas F. Duda, Jr. and Stephen R. Palumbi PMCID: PMC21999 The distribution and copy number of copia-like retrotransposons in rice (Oryza sativa L.) and their implications in the organization and evolution of the rice genome Shiping Wang, Nan Liu, Kaiman Peng, and Qifa Zhang PMCID: PMC22000 Genetics A new structure for the murine Xist gene and its relationship to chromosome choice/counting during X-chromosome inactivation Young-Kwon Hong, Sara D. Ontiveros, Caifu Chen, and William M. Strauss PMCID: PMC22001 GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast Sean M. Burgess, Masahiro Ajimura, and Nancy Kleckner PMCID: PMC22002 Human XIST yeast artificial chromosome transgenes show partial X inactivation center function in mouse embryonic stem cells Edith Heard, Fabien Mongelard, Danielle Arnaud, Corinne Chureau, Claire Vourc’h, and Philip Avner PMCID: PMC22003 An experimental solution for the Luria–Delbrück fluctuation problem in measuring hypermutation rates Jürgen Bachl, Mark Dessing, Carina Olsson, R. C. von Borstel, and Charles Steinberg PMCID: PMC22004 Different mutator phenotypes in Mlh1- versus Pms2-deficient mice Xiang Yao, Andrew B. Buermeyer, Latha Narayanan, Doan Tran, Sean M. Baker, Tomas A. Prolla, Peter M. Glazer, R. Michael Liskay, and Norman Arnheim PMCID: PMC22005 A novel mechanism for P element homing in Drosophila Emmanuel Taillebourg and Jean-Maurice Dura PMCID: PMC22006 The role of transient hypermutators in adaptive mutation in Escherichia coli William A. Rosche and Patricia L. Foster PMCID: PMC22007 Immunology Catalysis of peptide dissociation from class II MHC-peptide complexes Lutz Schmitt, Johannes R. Kratz, Mark M. Davis, and Harden M. McConnell PMCID: PMC21957 Paternal monoallelic expression of the paired immunoglobulin-like receptors PIR-A and PIR-B Ching-Cheng Chen, Vincent Hurez, J. Scott Brockenbrough, Hiromi Kubagawa, and Max D. Cooper PMCID: PMC22008 CCR5+ and CXCR3+ T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions Konstantin E. Balashov, James B. Rottman, Howard L. Weiner, and Wayne W. Hancock PMCID: PMC22009 Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB Veronika Groh, Rebecca Rhinehart, Heather Secrist, Stefan Bauer, Kenneth H. Grabstein, and Thomas Spies PMCID: PMC22010 Matrix metalloproteinase deficiencies affect contact hypersensitivity: Stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response Min Wang, Xuejin Qin, John S. Mudgett, Thomas A. Ferguson, Robert M. Senior, and Howard G. Welgus PMCID: PMC22011 The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes Hsiu-Ling Li, William W. Davis, Eileen L. Whiteman, Morris J. Birnbaum, and Ellen Puré PMCID: PMC22012 Antibodies to CD44 and integrin α4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment Stefan Brocke, Christopher Piercy, Lawrence Steinman, Irving L. Weissman, and Timo Veromaa PMCID: PMC22013 Medical Sciences Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1 Fahumiya Samad, K. Teoman Uysal, Sarah M. Wiesbrock, Manjula Pandey, Gökhan S. Hotamisligil, and David J. Loskutoff PMCID: PMC22014 Vancomycin-resistant enterococci in intensive-care hospital settings: Transmission dynamics, persistence, and the impact of infection control programs Daren J. Austin, Marc J. M. Bonten, Robert A. Weinstein, Sarah Slaughter, and Roy M. Anderson PMCID: PMC22015 MRP3, an organic anion transporter able to transport anti-cancer drugs Marcel Kool, Marcel van der Linden, Marcel de Haas, George L. Scheffer, J. Marleen L. de Vree, Alexander J. Smith, Gerrit Jansen, Godefridus J. Peters, Nico Ponne, Rik J. Scheper, Ronald P. J. Oude Elferink, Frank Baas, and Piet Borst PMCID: PMC22016 Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice Giuseppina Caligiuri, Bernard Levy, John Pernow, Peter Thorén, and Göran K. Hansson PMCID: PMC22017 Multiple event activation of a generic prodrug trigger by antibody catalysis Doron Shabat, Christoph Rader, Benjamin List, Richard A. Lerner, and Carlos F. Barbas, III PMCID: PMC22018 Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions Wolfgang Siess, Konrad J. Zangl, Markus Essler, Markus Bauer, Richard Brandl, Carolin Corrinth, Robert Bittman, Gabor Tigyi, and Martin Aepfelbacher PMCID: PMC22019 P19ARF stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2 Weikang Tao and Arnold J. Levine PMCID: PMC22020 p53 gene mutations are not required for early dissemination of cancer cells Sonja Offner, Werner Schmaus, Klaus Witter, Gustavo B. Baretton, Günter Schlimok, Bernward Passlick, Gert Riethmüller, and Klaus Pantel PMCID: PMC22021 An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens Monica M. Montano, Kirk Ekena, Regis Delage-Mourroux, Weiru Chang, Paolo Martini, and Benita S. Katzenellenbogen PMCID: PMC22022 Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewisx and Lewisx Shenlan Mao, Changshou Gao, Chih-Hung L. Lo, Peter Wirsching, Chi-Huey Wong, and Kim D. Janda PMCID: PMC22023 Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations Weihong Song, Philip Nadeau, Menglan Yuan, Xudong Yang, Jie Shen, and Bruce A. Yankner PMCID: PMC22024 Autoregulation of pituitary corticotroph SOCS-3 expression: Characterization of the murine SOCS-3 promoter C. J. Auernhammer, C. Bousquet, and S. Melmed PMCID: PMC22025 Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-γ-dependent mechanisms Patricia S. Walker, Tanya Scharton-Kersten, Arthur M. Krieg, Laurie Love-Homan, Edgar D. Rowton, Mark C. Udey, and Jonathan C. Vogel PMCID: PMC22026 Clonal dynamics of progressive neoplastic transformation Ming Chow and Harry Rubin PMCID: PMC22027 A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic Timo Imbach, Patricie Burda, Peter Kuhnert, Ron A. Wevers, Markus Aebi, Eric G. Berger, and Thierry Hennet PMCID: PMC22030 Molecular cloning, characterization, and promoter analysis of the human 25-hydroxyvitamin D3-1α-hydroxylase gene Xiang F. Kong, Xue H. Zhu, Yan L. Pei, David M. Jackson, and Michael F. Holick PMCID: PMC22032 Microbiology Immunization against genital herpes with a vaccine virus that has defects in productive and latent infection Xavier J. Da Costa, Cheryl A. Jones, and David M. Knipe PMCID: PMC22033 Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130 K. Smith-McCune, D. Kalman, C. Robbins, S. Shivakumar, L. Yuschenkoff, and J. Michael Bishop PMCID: PMC22035 Unexpected abundance of self-splicing introns in the genome of bacteriophage Twort: Introns in multiple genes, a single gene with three introns, and exon skipping by group I ribozymes Markus Landthaler and David A. Shub PMCID: PMC22036 Sequence anomalies in the Cag7 gene of the Helicobacter pylori pathogenicity island Guoying Liu, Timothy K. McDaniel, Stanley Falkow, and Samuel Karlin PMCID: PMC22039 A practical method for simultaneously determining the effective burst sizes and cycle times of viruses John L. Spouge and Scott P. Layne PMCID: PMC22041 Neurobiology Calexcitin transformation of GABAergic synapses: From excitation filter to amplifier Miao-Kun Sun, Thomas J. Nelson, Hui Xu, and Daniel L. Alkon PMCID: PMC22042 “Global” cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain Booma D. Yandava, Lori L. Billinghurst, and Evan Y. Snyder PMCID: PMC22044 Optical recording of light-evoked calcium signals in the functionally intact retina Winfried Denk and Peter B. Detwiler PMCID: PMC22046 Recombinant Semliki Forest virus and Sindbis virus efficiently infect neurons in hippocampal slice cultures Markus U. Ehrengruber, Kenneth Lundstrom, Christophe Schweitzer, Christian Heuss, Sondra Schlesinger, and Beat H. Gähwiler PMCID: PMC22049 Leptin actions on food intake and body temperature are mediated by IL-1 Giamal N. Luheshi, Jason D. Gardner, David A. Rushforth, Andrew S. Loudon, and Nancy J. Rothwell PMCID: PMC22051 Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood–brain barrier and specifically reduce gene expression Beth M. Tyler, Karen Jansen, Daniel J. McCormick, Christopher L. Douglas, Mona Boules, Jennifer A. Stewart, Lihong Zhao, Benjamin Lacy, Bernadette Cusack, Abdul Fauq, and Elliott Richelson PMCID: PMC22053 Pharmacology Progressive hypertrophy and heart failure in β1-adrenergic receptor transgenic mice Stefan Engelhardt, Lutz Hein, Frank Wiesmann, and Martin J. Lohse PMCID: PMC22055 Guanosine triphosphatase stimulation of oncogenic Ras mutants Mohammad Reza Ahmadian, Tsaffrir Zor, Dorothee Vogt, Wolfgang Kabsch, Zvi Selinger, Alfred Wittinghofer, and Klaus Scheffzek PMCID: PMC22057 Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A Scott H. Soderling, Sharon J. Bayuga, and Joseph A. Beavo PMCID: PMC22059 Physiology Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors α and β Sari Mäkelä, Hanna Savolainen, Einari Aavik, Marjukka Myllärniemi, Leena Strauss, Eero Taskinen, Jan-Åke Gustafsson, and Pekka Häyry PMCID: PMC22061 Identification of the gregarization-associated dark-pigmentotropin in locusts through an albino mutant Amer I. Tawfik, Seiji Tanaka, Arnold De Loof, Liliane Schoofs, Geert Baggerman, Etienne Waelkens, Rita Derua, Yoram Milner, Yoram Yerushalmi, and M. Paul Pener PMCID: PMC22063 Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice Klara Sjögren, Jun-Li Liu, Kristina Blad, Stanko Skrtic, Olle Vidal, Ville Wallenius, Derek LeRoith, Jan Törnell, Olle G. P. Isaksson, John-Olov Jansson, and Claes Ohlsson PMCID: PMC22065 Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine Katia P. Karalis, Effie Kontopoulos, Louis J. Muglia, and Joseph A. Majzoub PMCID: PMC22067 Plant Biology Map-based cloning of chloronerva, a gene involved in iron uptake of higher plants encoding nicotianamine synthase Hong-Qing Ling, Gudrun Koch, Helmut Bäumlein, and Martin W. Ganal PMCID: PMC22069 β-Phaseolin gene activation is a two-step process: PvALF- facilitated chromatin modification followed by abscisic acid-mediated gene activation Guofu Li, Kenneth J. Bishop, Mahesh B. Chandrasekharan, and Timothy C. Hall PMCID: PMC22071 AtPCS1, a phytochelatin synthase from Arabidopsis: Isolation and in vitro reconstitution Olena K. Vatamaniuk, Stéphane Mari, Yu-Ping Lu, and Philip A. Rea PMCID: PMC22073 Population Biology Vancomycin-resistant enterococci in intensive-care hospital settings: Transmission dynamics, persistence, and the impact of infection control programs Daren J. Austin, Marc J. M. Bonten, Robert A. Weinstein, Sarah Slaughter, and Roy M. Anderson PMCID: PMC22015 |
