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Volume 100(6);  March 18, 2003
Editorial
PNAS at volume 100
Nicholas R. Cozzarelli
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3005–3006. doi: 10.1073/pnas.0730842100.
PMCID: PMC152229
Commentaries
The dynamic spore
Adam Driks
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3007–3009. Published online 2003 March 11. doi: 10.1073/pnas.0730807100.
PMCID: PMC152230
Polyketide and non-ribosomal peptide synthases: Falling together by coming apart
C. Richard Hutchinson
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3010–3012. Published online 2003 March 11. doi: 10.1073/pnas.0730689100.
PMCID: PMC152231
Ozone in biology
Richard A. Lerner and Albert Eschenmoser
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3013–3015. Published online 2003 March 11. doi: 10.1073/pnas.0730791100.
PMCID: PMC152232
Component processes underlying choice
John T. Cacioppo and Howard S. Nusbaum
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3016–3017. Published online 2003 March 11. doi: 10.1073/pnas.0730744100.
PMCID: PMC152233
Diarrhea or colorectal cancer: Can bacterial toxins serve as a treatment for colon cancer?
S. L. Carrithers
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3018–3020. Published online 2003 March 11. doi: 10.1073/pnas.0730484100.
PMCID: PMC152234
Perspective
Revisiting the independence of the publicly and privately funded drafts of the human genome
Nicholas R. Cozzarelli
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3021. Published online 2003 March 11. doi: 10.1073/pnas.0830968100.
PMCID: PMC152235
More on the sequencing of the human genome
Robert H. Waterston, Eric S. Lander, and John E. Sulston
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3022–3024. Published online 2003 March 11. doi: 10.1073/pnas.0634129100.
PMCID: PMC152236
The independence of our genome assemblies
Mark D. Adams, Granger G. Sutton, Hamilton O. Smith, Eugene W. Myers, and J. Craig Venter
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3025–3026. Published online 2003 March 11. doi: 10.1073/pnas.0637478100.
PMCID: PMC152237
Type III secretion systems and bacterial flagella: Insights into their function from structural similarities
Ariel Blocker, Kaoru Komoriya, and Shin-Ichi Aizawa
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3027–3030. Published online 2003 March 11. doi: 10.1073/pnas.0535335100.
PMCID: PMC152238
Physical Sciences
Chemistry
From the Cover:
Investigating antibody-catalyzed ozone generation by human neutrophils
Bernard M. Babior, Cindy Takeuchi, Julie Ruedi, Abel Gutierrez, and Paul Wentworth, Jr.
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3031–3034. Published online 2003 February 24. doi: 10.1073/pnas.0530251100.
PMCID: PMC152239
Is the olfactory receptor a metalloprotein?
Jiangyun Wang, Zaida A. Luthey-Schulten, and Kenneth S. Suslick
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3035–3039. Published online 2003 February 27. doi: 10.1073/pnas.262792899.
PMCID: PMC152240
Chiral tubule self-assembly from an achiral diynoic lipid
Serhii Pakhomov, Robert P. Hammer, Bijaya K. Mishra, and Britt N. Thomas
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3040–3042. Published online 2003 March 7. doi: 10.1073/pnas.0030051100.
PMCID: PMC152241
Discrete two-terminal single nanocluster quantum optoelectronic logic operations at room temperature
Tae-Hee Lee and Robert M. Dickson
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3043–3046. Published online 2003 March 5. doi: 10.1073/pnas.0635474100.
PMCID: PMC152242
Watching proteins fold one molecule at a time
Elizabeth Rhoades, Eugene Gussakovsky, and Gilad Haran
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3197–3202. Published online 2003 February 28. doi: 10.1073/pnas.2628068100.
PMCID: PMC152269
Geophysics
Nuclear georeactor origin of oceanic basalt 3He/4He, evidence, and implications
J. Marvin Herndon
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3047–3050. Published online 2003 March 3. doi: 10.1073/pnas.0437778100.
PMCID: PMC152243
Physics
Discrete two-terminal single nanocluster quantum optoelectronic logic operations at room temperature
Tae-Hee Lee and Robert M. Dickson
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3043–3046. Published online 2003 March 5. doi: 10.1073/pnas.0635474100.
PMCID: PMC152242
Liquid–liquid phase transition in compressed hydrogen from first-principles simulations
Sandro Scandolo
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3051–3053. Published online 2003 March 7. doi: 10.1073/pnas.0038012100.
PMCID: PMC152244
Extending the definition of entropy to nonequilibrium steady states
David P. Ruelle
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3054–3058. Published online 2003 March 10. doi: 10.1073/pnas.0630567100.
PMCID: PMC152245
Biological Sciences
Applied Biological Sciences
A high-throughput gene expression analysis technique using competitive PCR and matrix-assisted laser desorption ionization time-of-flight MS
Chunming Ding and Charles R. Cantor
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3059–3064. Published online 2003 March 6. doi: 10.1073/pnas.0630494100.
PMCID: PMC152246
From the Cover:
Functional proteomics of nonalcoholic steatohepatitis: Mitochondrial proteins as targets of S-adenosylmethionine
Enrique Santamaría, Matías A. Avila, M. Ujue Latasa, Angel Rubio, Antonio Martín-Duce, Shelly C. Lu, José M. Mato, and Fernando J. Corrales
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3065–3070. Published online 2003 March 11. doi: 10.1073/pnas.0536625100.
PMCID: PMC152247
Computational and experimental analysis of DNA shuffling
Narendra Maheshri and David V. Schaffer
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3071–3076. Published online 2003 March 7. doi: 10.1073/pnas.0537968100.
PMCID: PMC152248
Biochemistry
From the Cover:
Investigating antibody-catalyzed ozone generation by human neutrophils
Bernard M. Babior, Cindy Takeuchi, Julie Ruedi, Abel Gutierrez, and Paul Wentworth, Jr.
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3031–3034. Published online 2003 February 24. doi: 10.1073/pnas.0530251100.
PMCID: PMC152239
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Laura L. Listenberger, Xianlin Han, Sarah E. Lewis, Sylvaine Cases, Robert V. Farese, Jr., Daniel S. Ory, and Jean E. Schaffer
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3077–3082. Published online 2003 March 10. doi: 10.1073/pnas.0630588100.
PMCID: PMC152249
Transcription termination control of the S box system: Direct measurement of S-adenosylmethionine by the leader RNA
Brooke A. Murphy McDaniel, Frank J. Grundy, Irina Artsimovitch, and Tina M. Henkin
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3083–3088. Published online 2003 March 7. doi: 10.1073/pnas.0630422100.
PMCID: PMC152250
Metabolic incorporation of unnatural sialic acids into Haemophilus ducreyi lipooligosaccharides
Scarlett Goon, Birgit Schilling, Michael V. Tullius, Bradford W. Gibson, and Carolyn R. Bertozzi
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3089–3094. Published online 2003 March 3. doi: 10.1073/pnas.0437851100.
PMCID: PMC152251
A Saccharomyces cerevisiae mutant strain defective in acetyl-CoA carboxylase arrests at the G2/M phase of the cell cycle
Walid Al-Feel, James C. DeMar, and Salih J. Wakil
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3095–3100. Published online 2003 March 7. doi: 10.1073/pnas.0538069100.
PMCID: PMC152252
A binding motif for Siah ubiquitin ligase
Colin M. House, Ian J. Frew, Huei-Luen Huang, Gerhard Wiche, Nadia Traficante, Edouard Nice, Bruno Catimel, and David D. L. Bowtell
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3101–3106. Published online 2003 March 7. doi: 10.1073/pnas.0534783100.
PMCID: PMC152253
Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae
Michael P. Washburn, Antonius Koller, Guy Oshiro, Ryan R. Ulaszek, David Plouffe, Cosmin Deciu, Elizabeth Winzeler, and John R. Yates, III
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3107–3112. Published online 2003 March 7. doi: 10.1073/pnas.0634629100.
PMCID: PMC152254
Loss of p16INK4a results in increased glucocorticoid receptor activity during fibrosarcoma development
Ramon Roca, Robert M. Kypta, and Maria d. M. Vivanco
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3113–3118. Published online 2003 March 6. doi: 10.1073/pnas.0634912100.
PMCID: PMC152255
Mutations that affect the ability of the vnd/NK-2 homeoprotein to regulate gene expression: Transgenic alterations and tertiary structure
Keita Koizumi, Carla Lintas, Marshall Nirenberg, Jin-Soo Maeng, Jeong-Ho Ju, James W. Mack, James M. Gruschus, Ward F. Odenwald, and James A. Ferretti
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3119–3124. Published online 2003 March 7. doi: 10.1073/pnas.0438043100.
PMCID: PMC152256
Non-heme iron protein: A potential target of nitric oxide in acute cardiac allograft rejection
Galen M. Pieper, Nadine L. N. Halligan, Gail Hilton, Eugene A. Konorev, Christopher C. Felix, Allan M. Roza, Mark B. Adams, and Owen W. Griffith
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3125–3130. Published online 2003 March 6. doi: 10.1073/pnas.0636938100.
PMCID: PMC152257
Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase
Zsolt Török, Nelly M. Tsvetkova, Gábor Balogh, Ibolya Horváth, Enikő Nagy, Zoltán Pénzes, Judit Hargitai, Olivier Bensaude, Péter Csermely, John H. Crowe, Bruno Maresca, and László Vígh
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3131–3136. Published online 2003 March 3. doi: 10.1073/pnas.0438003100.
PMCID: PMC152258
The 1.6-Å crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad
Paulene M. Quigley, Konstantin Korotkov, François Baneyx, and Wim G. J. Hol
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3137–3142. Published online 2003 March 5. doi: 10.1073/pnas.0530312100.
PMCID: PMC152259
Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution
Gavin J. Williams, Silvie Domann, Adam Nelson, and Alan Berry
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3143–3148. Published online 2003 March 7. doi: 10.1073/pnas.0635924100.
PMCID: PMC152260
From the Cover:
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis
Yi-Qiang Cheng, Gong-Li Tang, and Ben Shen
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3149–3154. Published online 2003 February 21. doi: 10.1073/pnas.0537286100.
PMCID: PMC152261
Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis
Daisuke Yabe, Ryutaro Komuro, Guosheng Liang, Joseph L. Goldstein, and Michael S. Brown
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3155–3160. Published online 2003 March 6. doi: 10.1073/pnas.0130116100.
PMCID: PMC152262
Biophysics
High-throughput approach for detection of DNA bending and flexibility based on cyclization
Yongli Zhang and Donald M. Crothers
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3161–3166. Published online 2003 March 10. doi: 10.1073/pnas.0530189100.
PMCID: PMC152263
Close identity of a pressure-stabilized intermediate with a kinetic intermediate in protein folding
Ryo Kitahara and Kazuyuki Akasaka
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3167–3172. Published online 2003 March 10. doi: 10.1073/pnas.0630309100.
PMCID: PMC152264
Mechanics of DNA packaging in viruses
Prashant K. Purohit, Jané Kondev, and Rob Phillips
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3173–3178. Published online 2003 March 10. doi: 10.1073/pnas.0737893100.
PMCID: PMC404299
Spectroscopic and morphological studies of human retinal lipofuscin granules
Nicole M. Haralampus-Grynaviski, Laura E. Lamb, Christine M. R. Clancy, Christine Skumatz, Janice M. Burke, Tadeusz Sarna, and John D. Simon
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3179–3184. Published online 2003 February 28. doi: 10.1073/pnas.0630280100.
PMCID: PMC152266
An affibody in complex with a target protein: Structure and coupled folding
Elisabet Wahlberg, Christofer Lendel, Magnus Helgstrand, Peter Allard, Vildan Dincbas-Renqvist, Anders Hedqvist, Helena Berglund, Per-Åke Nygren, and Torleif Härd
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3185–3190. Published online 2003 February 19. doi: 10.1073/pnas.0436086100.
PMCID: PMC152267
Structural basis for recognition by an in vitro evolved affibody
Martin Högbom, Malin Eklund, Per-Åke Nygren, and Pär Nordlund
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3191–3196. Published online 2003 February 25. doi: 10.1073/pnas.0436100100.
PMCID: PMC404300
Watching proteins fold one molecule at a time
Elizabeth Rhoades, Eugene Gussakovsky, and Gilad Haran
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3197–3202. Published online 2003 February 28. doi: 10.1073/pnas.2628068100.
PMCID: PMC152269
An approach to electrical modeling of single and multiple cells
Thiruvallur R. Gowrishankar and James C. Weaver
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3203–3208. Published online 2003 March 7. doi: 10.1073/pnas.0636434100.
PMCID: PMC152270
Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-Å x-ray data
Martin Högbom, Marcus Galander, Martin Andersson, Matthias Kolberg, Wulf Hofbauer, Günter Lassmann, Pär Nordlund, and Friedhelm Lendzian
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3209–3214. Published online 2003 March 6. doi: 10.1073/pnas.0536684100.
PMCID: PMC404301
Discrimination of native protein structures using atom–atom contact scoring
Brendan J. McConkey, Vladimir Sobolev, and Marvin Edelman
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3215–3220. Published online 2003 March 11. doi: 10.1073/pnas.0535768100.
PMCID: PMC152272
Cell Biology
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function
Ryo Iwamoto, Satoru Yamazaki, Masanori Asakura, Seiji Takashima, Hidetoshi Hasuwa, Kenji Miyado, Satoshi Adachi, Masafumi Kitakaze, Koji Hashimoto, Gerhard Raab, Daisuke Nanba, Shigeki Higashiyama, Masatsugu Hori, Michael Klagsbrun, and Eisuke Mekada
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3221–3226. Published online 2003 March 5. doi: 10.1073/pnas.0537588100.
PMCID: PMC152273
Myosin isoforms show unique conformations in the actin-bound state
Niels Volkmann, Greta Ouyang, Kathleen M. Trybus, David J. DeRosier, Susan Lowey, and Dorit Hanein
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3227–3232. Published online 2003 February 28. doi: 10.1073/pnas.0536510100.
PMCID: PMC152274
Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence
Anja Krones-Herzig, Eileen Adamson, and Dan Mercola
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3233–3238. Published online 2003 March 10. doi: 10.1073/pnas.2628034100.
PMCID: PMC152275
The topoisomerase IIβ circular clamp arrests transcription and signals a 26S proteasome pathway
Hai Xiao, Yong Mao, Shyamal D. Desai, Nai Zhou, Chun-Yuan Ting, Jaulang Hwang, and Leroy F. Liu
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3239–3244. Published online 2003 March 10. doi: 10.1073/pnas.0736401100.
PMCID: PMC152276
Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway
Sung Hee Baek, Chrissa Kioussi, Paola Briata, Degeng Wang, H. D. Nguyen, Kenneth A. Ohgi, Christopher K. Glass, Anthony Wynshaw-Boris, David W. Rose, and Michael G. Rosenfeld
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3245–3250. Published online 2003 March 10. doi: 10.1073/pnas.0330217100.
PMCID: PMC152277
Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
Hong Zhang, Kuang-Hung Pan, and Stanley N. Cohen
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3251–3256. Published online 2003 March 7. doi: 10.1073/pnas.2627983100.
PMCID: PMC152278
Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor
Lauren D. Wood, Brenda J. Irvin, Giuseppina Nucifora, K. Scott Luce, and Scott W. Hiebert
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3257–3262. Published online 2003 March 7. doi: 10.1073/pnas.0637114100.
PMCID: PMC152279
Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein
Robert F. Kalejta and Thomas Shenk
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3263–3268. Published online 2003 March 7. doi: 10.1073/pnas.0538058100.
PMCID: PMC152280
The spatial targeting and nuclear matrix binding domains of SRm160
Stefan Wagner, Simion Chiosea, and Jeffrey A. Nickerson
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3269–3274. Published online 2003 March 6. doi: 10.1073/pnas.0438055100.
PMCID: PMC152281
From the Cover:
The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling
Zheng Fu, Eliah Aronoff-Spencer, Jonathan M. Backer, and Gary J. Gerfen
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3275–3280. Published online 2003 March 10. doi: 10.1073/pnas.0535975100.
PMCID: PMC152282
The matrix attachment region in the Chinese hamster dihydrofolate reductase origin of replication may be required for local chromatid separation
L. D. Mesner, J. L. Hamlin, and P. A. Dijkwel
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3281–3286. Published online 2003 March 10. doi: 10.1073/pnas.0437791100.
PMCID: PMC152283
Developmental Biology
Gelsolin is a dorsalizing factor in zebrafish
Jyotshnabala Kanungo, Zbynek Kozmik, Shivalingappa K. Swamynathan, and Joram Piatigorsky
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3287–3292. Published online 2003 March 10. doi: 10.1073/pnas.0634473100.
PMCID: PMC152284
Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster
Sergi Beltran, Enrique Blanco, Florenci Serras, Beatriz Pérez-Villamil, Roderic Guigó, Spyros Artavanis-Tsakonas, and Montserrat Corominas
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3293–3298. Published online 2003 March 7. doi: 10.1073/pnas.0538075100.
PMCID: PMC152285
Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors
Silvia Maretto, Michelangelo Cordenonsi, Sirio Dupont, Paola Braghetta, Vania Broccoli, A. Bassim Hassan, Dino Volpin, Giorgio M. Bressan, and Stefano Piccolo
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3299–3304. Published online 2003 March 7. doi: 10.1073/pnas.0434590100.
PMCID: PMC152286
Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells
Huilin Qi, Dean J. Aguiar, Shelly M. Williams, Alison La Pean, Wei Pan, and Catherine M. Verfaillie
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3305–3310. Published online 2003 March 11. doi: 10.1073/pnas.0532693100.
PMCID: PMC152287
X-inactivation patch size in human female tissue confounds the assessment of tumor clonality
Marco Novelli, Antonio Cossu, Dahmane Oukrif, Alberto Quaglia, Sunil Lakhani, Richard Poulsom, Peter Sasieni, Piera Carta, Marcella Contini, Anna Pasca, Giuseppe Palmieri, Walter Bodmer, Francesco Tanda, and Nick Wright
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3311–3314. Published online 2003 February 27. doi: 10.1073/pnas.0437825100.
PMCID: PMC152288
Maternal induction of ventral fate by zebrafish radar
Samuel Sidi, Carole Goutel, Nadine Peyriéras, and Frédéric M. Rosa
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3315–3320. Published online 2003 February 24. doi: 10.1073/pnas.0530115100.
PMCID: PMC152289
Ecology
On the pattern of discovery of introduced species
Christopher J. Costello and Andrew R. Solow
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3321–3323. Published online 2003 March 3. doi: 10.1073/pnas.0636536100.
PMCID: PMC152290
Evolution
Human specific loss of olfactory receptor genes
Yoav Gilad, Orna Man, Svante Pääbo, and Doron Lancet
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3324–3327. Published online 2003 February 28. doi: 10.1073/pnas.0535697100.
PMCID: PMC152291
Relaxed selective pressure on an essential component of pheromone transduction in primate evolution
Emily R. Liman and Hideki Innan
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3328–3332. Published online 2003 March 11. doi: 10.1073/pnas.0636123100.
PMCID: PMC152292
Cost minimization by helpers in cooperative vertebrates
A. F. Russell, L. L. Sharpe, P. N. M. Brotherton, and T. H. Clutton-Brock
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3333–3338. Published online 2003 March 10. doi: 10.1073/pnas.0636503100.
PMCID: PMC152293
Genetics
Integrating regulatory motif discovery and genome-wide expression analysis
Erin M. Conlon, X. Shirley Liu, Jason D. Lieb, and Jun S. Liu
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3339–3344. Published online 2003 March 7. doi: 10.1073/pnas.0630591100.
PMCID: PMC152294
Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin
Amani Zewail, Michael W. Xie, Yi Xing, Lan Lin, P. Fred Zhang, Wei Zou, Jonathan P. Saxe, and Jing Huang
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3345–3350. Published online 2003 March 3. doi: 10.1073/pnas.0530118100.
PMCID: PMC152295
Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms
Orly Alter, Patrick O. Brown, and David Botstein
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3351–3356. Published online 2003 March 11. doi: 10.1073/pnas.0530258100.
PMCID: PMC152296
An A−71C substitution in a green gene at the second position in the red/green visual-pigment gene array is associated with deutan color-vision deficiency
Hisao Ueyama, Yao-Hua Li, Gui-Lian Fu, Patcharee Lertrit, La-ongsri Atchaneeyasakul, Sanae Oda, Shoko Tanabe, Yasuhiro Nishida, Shinichi Yamade, and Iwao Ohkubo
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3357–3362. Published online 2003 March 7. doi: 10.1073/pnas.0637437100.
PMCID: PMC152297
Transposon telomeres are widely distributed in the Drosophila genus: TART elements in the virilis group
Elena Casacuberta and Mary-Lou Pardue
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3363–3368. Published online 2003 March 7. doi: 10.1073/pnas.0230353100.
PMCID: PMC152298
Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies
James H. Marden, Blanka Rogina, Kristi L. Montooth, and Stephen L. Helfand
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3369–3373. Published online 2003 March 7. doi: 10.1073/pnas.0634985100.
PMCID: PMC152299
Sequences in the Aγ–δ intergenic region are not required for stage-specific regulation of the human β-globin gene locus
Karin M. L. Gaensler, Zemin Zhang, Chin Lin, Suya Yang, Karin Hardt, and Linda Flebbe-Rehwaldt
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3374–3379. Published online 2003 March 10. doi: 10.1073/pnas.0634132100.
PMCID: PMC152300
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse
Tim Wiltshire, Mathew T. Pletcher, Serge Batalov, S. Whitney Barnes, Lisa M. Tarantino, Michael P. Cooke, Hua Wu, Kevin Smylie, Andrey Santrosyan, Neal G. Copeland, Nancy A. Jenkins, Francis Kalush, Richard J. Mural, Richard J. Glynne, Steve A. Kay, Mark D. Adams, and Colin F. Fletcher
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3380–3385. Published online 2003 February 28. doi: 10.1073/pnas.0130101100.
PMCID: PMC152301
Immunology
Antigen presentation by keratinocytes directs autoimmune skin disease
Lian Fan, Brian W. Busser, Traci Q. Lifsted, David Lo, and Terri M. Laufer
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3386–3391. Published online 2003 March 10. doi: 10.1073/pnas.0437899100.
PMCID: PMC152302
Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity
SangKon Oh, Jay A. Berzofsky, Donald S. Burke, Thomas A. Waldmann, and Liyanage P. Perera
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3392–3397. Published online 2003 March 7. doi: 10.1073/pnas.0630592100.
PMCID: PMC152303
Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction
Jan C. Schmollinger, Robert H. Vonderheide, Kara M. Hoar, Britta Maecker, Joachim L. Schultze, F. Stephen Hodi, Robert J. Soiffer, Ken Jung, Marcelo J. Kuroda, Norman L. Letvin, Edward A. Greenfield, Martin Mihm, Jeffery L. Kutok, and Glenn Dranoff
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3398–3403. Published online 2003 March 7. doi: 10.1073/pnas.0530311100.
PMCID: PMC152304
Medical Sciences
Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration
Kenichi Yamahara, Hiroshi Itoh, Tae-Hwa Chun, Yoshihiro Ogawa, Jun Yamashita, Naoki Sawada, Yasutomo Fukunaga, Masakatsu Sone, Takami Yurugi-Kobayashi, Kazutoshi Miyashita, Hirokazu Tsujimoto, Hyun Kook, Robert Feil, David L. Garbers, Franz Hofmann, and Kazuwa Nakao
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3404–3409. Published online 2003 March 5. doi: 10.1073/pnas.0538059100.
PMCID: PMC152305
Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum
John B. Welsh, Lisa M. Sapinoso, Suzanne G. Kern, David A. Brown, Tao Liu, Asne R. Bauskin, Robyn L. Ward, Nicholas J. Hawkins, David I. Quinn, Pamela J. Russell, Robert L. Sutherland, Samuel N. Breit, Christopher A. Moskaluk, Henry F. Frierson, Jr., and Garret M. Hampton
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3410–3415. Published online 2003 March 6. doi: 10.1073/pnas.0530278100.
PMCID: PMC152306
Potent inhibition of scrapie prion replication in cultured cells by bis-acridines
Barnaby C. H. May, Aaron T. Fafarman, Septima B. Hong, Michael Rogers, Leslie W. Deady, Stanley B. Prusiner, and Fred E. Cohen
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3416–3421. Published online 2003 March 7. doi: 10.1073/pnas.2627988100.
PMCID: PMC152307
Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo
Barbara Murdoch, Kristin Chadwick, Matthew Martin, Farbod Shojaei, Kavita V. Shah, Lisa Gallacher, Randall T. Moon, and Mickie Bhatia
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3422–3427. Published online 2003 March 7. doi: 10.1073/pnas.0130233100.
PMCID: PMC152308
Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes
Zhiyong Wang, Enrico Moro, Kalman Kovacs, Run Yu, and Shlomo Melmed
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3428–3432. Published online 2003 March 7. doi: 10.1073/pnas.0638052100.
PMCID: PMC152309
The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors
Carl E. Mackewicz, Charles S. Craik, and Jay A. Levy
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3433–3438. Published online 2003 March 6. doi: 10.1073/pnas.0630379100.
PMCID: PMC152310
Therapeutic photobiomodulation for methanol-induced retinal toxicity
J. T. Eells, M. M. Henry, P. Summerfelt, M. T. T. Wong-Riley, E. V. Buchmann, M. Kane, N. T. Whelan, and H. T. Whelan
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3439–3444. Published online 2003 March 7. doi: 10.1073/pnas.0534746100.
PMCID: PMC152311
Enhanced insulin sensitivity in mice lacking ganglioside GM3
Tadashi Yamashita, Akira Hashiramoto, Martin Haluzik, Hiroki Mizukami, Shoshannah Beck, Aaron Norton, Mari Kono, Shuichi Tsuji, Jose Luis Daniotti, Norbert Werth, Roger Sandhoff, Konrad Sandhoff, and Richard L. Proia
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3445–3449. Published online 2003 March 10. doi: 10.1073/pnas.0635898100.
PMCID: PMC152312
Long-term correction of globotriaosylceramide storage in Fabry mice by recombinant adeno-associated virus-mediated gene transfer
Jinhee Park, Gary J. Murray, Advait Limaye, Jane M. Quirk, Monique P. Gelderman, Roscoe O. Brady, and Pankaj Qasba
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3450–3454. Published online 2003 March 6. doi: 10.1073/pnas.0537900100.
PMCID: PMC152313
Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases
Mathias Chamaillard, Dana Philpott, Stephen E. Girardin, Habib Zouali, Suzanne Lesage, Fabrice Chareyre, The Hung Bui, Marco Giovannini, Ulrich Zaehringer, Virginie Penard-Lacronique, Philippe J. Sansonetti, Jean-Pierre Hugot, and Gilles Thomas
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3455–3460. Published online 2003 March 7. doi: 10.1073/pnas.0530276100.
PMCID: PMC152314
Microbiology
Kinetics of size changes of individual Bacillus thuringiensis spores in response to changes in relative humidity
Andrew J. Westphal, P. Buford Price, Terrance J. Leighton, and Katherine E. Wheeler
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3461–3466. Published online 2003 February 12. doi: 10.1073/pnas.232710999.
PMCID: PMC152315
The impact of parietal cells on Helicobacter pylori tropism and host pathology: An analysis using gnotobiotic normal and transgenic mice
Andrew J. Syder, Jung D. Oh, Janaki L. Guruge, David O'Donnell, Maria Karlsson, Jason C. Mills, Britta M. Björkholm, and Jeffrey I. Gordon
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3467–3472. Published online 2003 March 10. doi: 10.1073/pnas.0230380100.
PMCID: PMC152316
Link between immune response and parasite synchronization in malaria
Igor M. Rouzine and F. Ellis McKenzie
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3473–3478. Published online 2003 March 5. doi: 10.1073/pnas.262796299.
PMCID: PMC152317
Neuroscience
Persistence and brain circuitry
Debra A. Gusnard, John M. Ollinger, Gordon L. Shulman, C. Robert Cloninger, Joseph L. Price, David C. Van Essen, and Marcus E. Raichle
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3479–3484. Published online 2003 March 7. doi: 10.1073/pnas.0538050100.
PMCID: PMC152318
Control of neurotransmitter release by an internal gel matrix in synaptic vesicles
David Reigada, Ismael Díez-Pérez, Pau Gorostiza, Albert Verdaguer, Inmaculada Gómez de Aranda, Oriol Pineda, Jaume Vilarrasa, Jordi Marsal, Joan Blasi, Jordi Aleu, and Carles Solsona
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3485–3490. Published online 2003 March 10. doi: 10.1073/pnas.0336914100.
PMCID: PMC152319
Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels
Francisco J. Urbano, Erika S. Piedras-Rentería, Kisun Jun, Hee-Sup Shin, Osvaldo D. Uchitel, and Richard W. Tsien
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3491–3496. Published online 2003 March 6. doi: 10.1073/pnas.0437991100.
PMCID: PMC152320
Neuroglobin protects the brain from experimental stroke in vivo
Yunjuan Sun, Kunlin Jin, Alyson Peel, Xiao Ou Mao, Lin Xie, and David A. Greenberg
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3497–3500. Published online 2003 March 5. doi: 10.1073/pnas.0637726100.
PMCID: PMC152321
The power of human brain magnetoencephalographic signals can be modulated up or down by changes in an attentive visual task
Yanqing Chen, Anil K. Seth, Joseph A. Gally, and Gerald M. Edelman
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3501–3506. Published online 2003 March 7. doi: 10.1073/pnas.0337630100.
PMCID: PMC152322
From the Cover:
The impact of the certainty context on the process of choice
John Dickhaut, Kevin McCabe, Jennifer C. Nagode, Aldo Rustichini, Kip Smith, and José V. Pardo
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3536–3541. Published online 2003 March 7. doi: 10.1073/pnas.0530279100.
PMCID: PMC404302
Physiology
Kinetics of size changes of individual Bacillus thuringiensis spores in response to changes in relative humidity
Andrew J. Westphal, P. Buford Price, Terrance J. Leighton, and Katherine E. Wheeler
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3461–3466. Published online 2003 February 12. doi: 10.1073/pnas.232710999.
PMCID: PMC152315
An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node
Sebastian K. G. Maier, Ruth E. Westenbroek, T. T. Yamanushi, H. Dobrzynski, Mark R. Boyett, William A. Catterall, and Todd Scheuer
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3507–3512. Published online 2003 March 11. doi: 10.1073/pnas.2627986100.
PMCID: PMC152323
Plant Biology
Intein-mediated assembly of a functional β-glucuronidase in transgenic plants
Jianjun Yang, George C. Fox, Jr., and Tina V. Henry-Smith
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3513–3518. Published online 2003 March 10. doi: 10.1073/pnas.0635899100.
PMCID: PMC152324
Interplay of the Arabidopsis nonhost resistance gene NHO1 with bacterial virulence
Li Kang, Jianxiong Li, Tiehan Zhao, Fangming Xiao, Xiaoyan Tang, Roger Thilmony, ShengYang He, and Jian-Min Zhou
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3519–3524. Published online 2003 March 7. doi: 10.1073/pnas.0637377100.
PMCID: PMC152325
Increasing vitamin C content of plants through enhanced ascorbate recycling
Zhong Chen, Todd E. Young, Jun Ling, Su-Chih Chang, and Daniel R. Gallie
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3525–3530. Published online 2003 March 6. doi: 10.1073/pnas.0635176100.
PMCID: PMC152326
Social Sciences
Anthropology
The evolution of altruistic punishment
Robert Boyd, Herbert Gintis, Samuel Bowles, and Peter J. Richerson
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3531–3535. Published online 2003 March 11. doi: 10.1073/pnas.0630443100.
PMCID: PMC152327
Economic Sciences
From the Cover:
The impact of the certainty context on the process of choice
John Dickhaut, Kevin McCabe, Jennifer C. Nagode, Aldo Rustichini, Kip Smith, and José V. Pardo
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3536–3541. Published online 2003 March 7. doi: 10.1073/pnas.0530279100.
PMCID: PMC404302
Corrections
Correction
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3542. Published online 2003 March 4. doi: 10.1073/pnas.0630528100.
PMCID: PMC152227
Corrects: Christopher J. Hupfeld, et al. β-Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of β2 adrenergic receptor Gαs signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2003 January 7; 100(1): 161–166.
Correction
Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3542. Published online 2003 February 26. doi: 10.1073/pnas.0630139100.
PMCID: PMC152228
Corrects: Katarzyna Lundmark, et al. Transmissibility of systemic amyloidosis by a prion-like mechanism. Proc Natl Acad Sci U S A. 2002 May 14; 99(10): 6979–6984.
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