| | This journal provides immediate access to some articles. Commentaries Progress on canalization Stephen C. Stearns PMCID: PMC124892 Glycosylation defining cancer malignancy: New wine in an old bottle Senitiroh Hakomori PMCID: PMC124893 How many species of prokaryotes are there? Bess B. Ward PMCID: PMC124894 Appraising the brain's energy budget Marcus E. Raichle and Debra A. Gusnard PMCID: PMC124895 Nuclear-mediated mitochondrial gene regulation and male fertility in higher plants: Light at the end of the tunnel? Roger P. Wise and Daryl R. Pring PMCID: PMC124896 Imprinted gene expression, transplantation medicine, and the “other” human embryonic stem cell Carmen Sapienza PMCID: PMC124897 Physical Sciences Applied Mathematics Numerical operator calculus in higher dimensions Gregory Beylkin and Martin J. Mohlenkamp PMCID: PMC124898 Concentration fluctuations in a mesoscopic oscillating chemical reaction system Hong Qian, Saveez Saffarian, and Elliot L. Elson PMCID: PMC124922 Supply–demand balance and metabolic scaling Jayanth R. Banavar, John Damuth, Amos Maritan, and Andrea Rinaldo PMCID: PMC124956 Applied Physical Sciences Soft, conformable electrical contacts for organic semiconductors: High-resolution plastic circuits by lamination Yueh-Lin Loo, Takao Someya, Kirk W. Baldwin, Zhenan Bao, Peter Ho, Ananth Dodabalapur, Howard E. Katz, and John A. Rogers PMCID: PMC124899 Three-dimensional stellarator codes P. R. Garabedian PMCID: PMC124900 Chemistry De novo determination of peptide structure with solid-state magic-angle spinning NMR spectroscopy Chad M. Rienstra, Lisa Tucker-Kellogg, Christopher P. Jaroniec, Morten Hohwy, Bernd Reif, Michael T. McMahon, Bruce Tidor, Tomás Lozano-Pérez, and Robert G. Griffin PMCID: PMC124901 From the Cover:
The molecular structure of spider dragline silk: Folding and orientation of the protein backbone J. D. van Beek, S. Hess, F. Vollrath, and B. H. Meier PMCID: PMC124902 Engineering In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution β+-sensitive microprobe Frédéric Pain, Laurent Besret, Françoise Vaufrey, Marie-Claude Grégoire, Laurent Pinot, Philippe Gervais, Lydie Ploux, Gilles Bloch, Roland Mastrippolito, Philippe Lanièce, and Philippe Hantraye PMCID: PMC125052 Physics Strongly enhanced field-dependent single-molecule electroluminescence Tae-Hee Lee, Jose I. Gonzalez, and Robert M. Dickson PMCID: PMC124903 Biological Sciences Anthropology Evidence for the control of phytolith formation in Cucurbita fruits by the hard rind (Hr) genetic locus: Archaeological and ecological implications Dolores R. Piperno, Irene Holst, Linda Wessel-Beaver, and Thomas C. Andres PMCID: PMC125074 Applied Biological Sciences Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain Imre Szabo, Xiao-Hong Chen, Li Xin, Martin W. Adler, O. M. Z. Howard, Joost J. Oppenheim, and Thomas J. Rogers PMCID: PMC124904 Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia Lucia Bartoloni, Jean-Louis Blouin, Yanzhen Pan, Corinne Gehrig, Amit K. Maiti, Nathalie Scamuffa, Colette Rossier, Mark Jorissen, Miguel Armengot, Maggie Meeks, Hannah M. Mitchison, Eddie M. K. Chung, Celia D. Delozier-Blanchet, William J. Craigen, and Stylianos E. Antonarakis PMCID: PMC124905 Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo William G. Brodbeck, Jasmine Patel, Gabriela Voskerician, Elizabeth Christenson, Matthew S. Shive, Yasuhide Nakayama, Takehisa Matsuda, Nicholas P. Ziats, and James M. Anderson PMCID: PMC124906 Biochemistry Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects Xiaorong Zhu, An Zhou, Arunangsu Dey, Christina Norrbom, Raymond Carroll, Chunling Zhang, Virginie Laurent, Iris Lindberg, Randi Ugleholdt, Jens J. Holst, and Donald F. Steiner PMCID: PMC124907 Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3 Xiaorong Zhu, Lelio Orci, Raymond Carroll, Christina Norrbom, Mariella Ravazzola, and Donald F. Steiner PMCID: PMC124908 Two sequence motifs from HIF-1α bind to the DNA-binding site of p53 Lars O. Hansson, Assaf Friedler, Stefan Freund, Stefan Rüdiger, and Alan R. Fersht PMCID: PMC124909 The structure of a replication initiator unites diverse aspects of nucleic acid metabolism Ramón Campos-Olivas, John M. Louis, Danielle Clérot, Bruno Gronenborn, and Angela M. Gronenborn PMCID: PMC124910 From the Cover:
A clogged gutter mechanism for protease inhibitors Evette S. Radisky and Daniel E. Koshland, Jr. PMCID: PMC124911 Riboflavin is a component of the Na+-pumping NADH–quinone oxidoreductase from Vibrio cholerae Blanca Barquera, Weidong Zhou, Joel E. Morgan, and Robert B. Gennis PMCID: PMC124912 Structure of decay-accelerating factor bound to echovirus 7: A virus-receptor complex Yongning He, Feng Lin, Paul R. Chipman, Carol M. Bator, Timothy S. Baker, Menachem Shoham, Richard J. Kuhn, M. Edward Medof, and Michael G. Rossmann PMCID: PMC124913 Absolute requirement of spermidine for growth and cell cycle progression of fission yeast (Schizosaccharomyces pombe) Manas K. Chattopadhyay, Celia White Tabor, and Herbert Tabor PMCID: PMC124914 Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness Nadim Jessani, Yongsheng Liu, Mark Humphrey, and Benjamin F. Cravatt PMCID: PMC124915 Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions Mahesh S. Joshi, T. Bruce Ferguson, Jr., Tae H. Han, Daniel R. Hyduke, James C. Liao, Tienush Rassaf, Nathan Bryan, Martin Feelisch, and Jack R. Lancaster, Jr. PMCID: PMC124916 The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane Alexia Garrigues, Alexandre E. Escargueil, and Stéphane Orlowski PMCID: PMC124917 Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase Christopher S. Brower, Shigeo Sato, Chieri Tomomori-Sato, Takumi Kamura, Arnim Pause, Robert Stearman, Richard D. Klausner, Sohail Malik, William S. Lane, Irina Sorokina, Robert G. Roeder, Joan Weliky Conaway, and Ronald C. Conaway PMCID: PMC124918 Experimental evaluation of topological parameters determining protein-folding rates Erik J. Miller, Kael F. Fischer, and Susan Marqusee PMCID: PMC124919 Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53 Chun-Qi Li, Laura J. Trudel, and Gerald N. Wogan PMCID: PMC124920 Biophysics From the Cover:
The molecular structure of spider dragline silk: Folding and orientation of the protein backbone J. D. van Beek, S. Hess, F. Vollrath, and B. H. Meier PMCID: PMC124902 Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy I. I. Serysheva, S. J. Ludtke, M. R. Baker, W. Chiu, and S. L. Hamilton PMCID: PMC124921 Concentration fluctuations in a mesoscopic oscillating chemical reaction system Hong Qian, Saveez Saffarian, and Elliot L. Elson PMCID: PMC124922 Roles of mutation and recombination in the evolution of protein thermodynamics Yu Xia and Michael Levitt PMCID: PMC124923 The search for local native-like nucleation centers in the unfolded state of β-sheet proteins Gregory V. Nikiforovich and Carl Frieden PMCID: PMC124924 An atomically detailed study of the folding pathways of protein A with the stochastic difference equation Avijit Ghosh, Ron Elber, and Harold A. Scheraga PMCID: PMC124925 On the calculation of absolute macromolecular binding free energies Hengbin Luo and Kim Sharp PMCID: PMC124926 The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy Qing Xie, Weishu Bu, Smita Bhatia, Joan Hare, Thayumanasamy Somasundaram, Arezki Azzi, and Michael S. Chapman PMCID: PMC124927 Smaller is better—but not too small: A physical scale for the design of the mammalian pulmonary acinus Bernard Sapoval, M. Filoche, and E. R. Weibel PMCID: PMC124928 Cell Biology The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans James F. Morley, Heather R. Brignull, Jill J. Weyers, and Richard I. Morimoto PMCID: PMC124929 Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis Carsten Willam, Norma Masson, Ya-Min Tian, S. Aleema Mahmood, Michael I. Wilson, Roy Bicknell, Kai-Uwe Eckardt, Patrick H. Maxwell, Peter J. Ratcliffe, and Christopher W. Pugh PMCID: PMC124930 Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo Leonard James and Robert N. Eisenman PMCID: PMC124931 Increasing plant susceptibility to Agrobacterium infection by overexpression of the Arabidopsis nuclear protein VIP1 Tzvi Tzfira, Manjusha Vaidya, and Vitaly Citovsky PMCID: PMC124932 C1qRp defines a new human stem cell population with hematopoietic and hepatic potential Guénahel H. Danet, Jennifer L. Luongo, Gary Butler, Min Min Lu, Andrea J. Tenner, M. Celeste Simon, and Dominique A. Bonnet PMCID: PMC124933 Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells Undine Lauf, Ben N. G. Giepmans, Patricia Lopez, Sébastien Braconnot, Shu-Chih Chen, and Matthias M. Falk PMCID: PMC124935 Mechanisms of polarization of the shape of fibroblasts and epitheliocytes: Separation of the roles of microtubules and Rho-dependent actin–myosin contractility T. Omelchenko, J. M. Vasiliev, I. M. Gelfand, H. H. Feder, and E. M. Bonder PMCID: PMC124937 Developmental Biology Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer Maria P. De Miguel, Linzhao Cheng, Eric C. Holland, Mark J. Federspiel, and Peter J. Donovan PMCID: PMC124938 Neuregulin-1 promotes formation of the murine cardiac conduction system Stacey Rentschler, Jennifer Zander, Kathleen Meyers, David France, Rebecca Levine, George Porter, Scott A. Rivkees, Gregory E. Morley, and Glenn I. Fishman PMCID: PMC124940 Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish Percy Lee, Katsutoshi Goishi, Alan J. Davidson, Robert Mannix, Leonard Zon, and Michael Klagsbrun PMCID: PMC124944 Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure Sara C. Ahlgren, Vijaya Thakur, and Marianne Bronner-Fraser PMCID: PMC124946 Early restriction of peripheral and proximal cell lineages during formation of the lung Anne-Karina T. Perl, Susan E. Wert, Andras Nagy, Corrinne G. Lobe, and Jeffrey A. Whitsett PMCID: PMC124949 The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation Zhan Yin, Jennifer Haynie, Xiaoming Yang, Baoguang Han, Songsak Kiatchoosakun, Joseph Restivo, Saying Yuan, Nanduri R. Prabhakar, Karl Herrup, Ronald A. Conlon, Brian D. Hoit, Michiko Watanabe, and Yu-Chung Yang PMCID: PMC124951 Ecology From the Cover:
Estimating prokaryotic diversity and its limits Thomas P. Curtis, William T. Sloan, and Jack W. Scannell PMCID: PMC124953 A trophic cascade regulates salt marsh primary production Brian Reed Silliman and Mark D. Bertness PMCID: PMC124954 Supply–demand balance and metabolic scaling Jayanth R. Banavar, John Damuth, Amos Maritan, and Andrea Rinaldo PMCID: PMC124956 Evidence for the control of phytolith formation in Cucurbita fruits by the hard rind (Hr) genetic locus: Archaeological and ecological implications Dolores R. Piperno, Irene Holst, Linda Wessel-Beaver, and Thomas C. Andres PMCID: PMC125074 Evolution Intracellular gene transfer: Reduced hydrophobicity facilitates gene transfer for subunit 2 of cytochrome c oxidase Daniel O. Daley, Rachel Clifton, and James Whelan PMCID: PMC124958 The metapopulation genetic algorithm: An efficient solution for the problem of large phylogeny estimation Alan R. Lemmon and Michel C. Milinkovitch PMCID: PMC124960 Tracing the LINEs of human evolution Igor Ovchinnikov, Adrienne Rubin, and Gary D. Swergold PMCID: PMC124962 Waddington's canalization revisited: Developmental stability and evolution Mark L. Siegal and Aviv Bergman PMCID: PMC124963 Sympatric speciation by sexual conflict Sergey Gavrilets and David Waxman PMCID: PMC124966 A strong signature of balancing selection in the 5′ cis-regulatory region of CCR5 Michael J. Bamshad, Srinivas Mummidi, Enrique Gonzalez, Seema S. Ahuja, Diane M. Dunn, W. Scott Watkins, Stephen Wooding, Anne C. Stone, Lynn B. Jorde, Robert B. Weiss, and Sunil K. Ahuja PMCID: PMC124967 A hemocyanin from the Onychophora and the emergence of respiratory proteins Kristina Kusche, Hilke Ruhberg, and Thorsten Burmester PMCID: PMC124969 Genetics Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism Haruko Takeda, Marika Takami, Tomoko Oguni, Takehito Tsuji, Kazuhiro Yoneda, Hiroaki Sato, Naoya Ihara, Tomohito Itoh, Srinivas R. Kata, Yuji Mishina, James E. Womack, Yasuo Moritomo, Yoshikazu Sugimoto, and Tetsuo Kunieda PMCID: PMC124971 Assigning numbers to the arrows: Parameterizing a gene regulation network by using accurate expression kinetics Michal Ronen, Revital Rosenberg, Boris I. Shraiman, and Uri Alon PMCID: PMC124972 Patterned variation in murine MHC promoters N. Avrion Mitchison and Jürgen Roes PMCID: PMC124974 Somatic stem cells and the kinetics of mutagenesis and carcinogenesis John Cairns PMCID: PMC124976 Clusters of transcription-coupled repair in the human genome Jordi Surrallés, María J. Ramírez, Ricard Marcos, Adayapalam T. Natarajan, and Leon H. F. Mullenders PMCID: PMC124978 High-resolution SNP mapping by denaturing HPLC Knud Nairz, Hugo Stocker, Benno Schindelholz, and Ernst Hafen PMCID: PMC124979 A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila Cornelia Kiefer, Emerich Sumser, Mathias F. Wernet, and Johannes von Lintig PMCID: PMC124981 Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice Vijay K. Yechoor, Mary-Elizabeth Patti, Robert Saccone, and C. Ronald Kahn PMCID: PMC124982 Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3′ end processing in Drosophila Béatrice Benoit, François Juge, Florence Iral, Agnès Audibert, and Martine Simonelig PMCID: PMC124984 Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages Patrick Onyango, Shan Jiang, Hiroshi Uejima, Michael J. Shamblott, John D. Gearhart, Hengmi Cui, and Andrew P. Feinberg PMCID: PMC124986 Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast Denise Hanway, Jodie K. Chin, Gang Xia, Guy Oshiro, Elizabeth A. Winzeler, and Floyd E. Romesberg PMCID: PMC124988 Global analysis of stress-regulated mRNA turnover by using cDNA arrays Jinshui Fan, Xiaoling Yang, Wengong Wang, William H. Wood, III, Kevin G. Becker, and Myriam Gorospe PMCID: PMC124989 Immunology Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction Jae-Hyuck Shim, Heung-Kyu Lee, Eun-Ju Chang, Wook-Jin Chae, Jin-Hwan Han, Duck-Jong Han, Tomohiro Morio, Jung-Jin Yang, Alfred Bothwell, and Sang-Kyou Lee PMCID: PMC124991 In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production Liying Guo, Jane Hu-Li, Jinfang Zhu, Cynthia J. Watson, Michael J. Difilippantonio, Christophe Pannetier, and William E. Paul PMCID: PMC124993 Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations Yasuhiro Nagata, Satoru Ono, Mitsutoshi Matsuo, Sacha Gnjatic, Danila Valmori, Gerd Ritter, Wendy Garrett, Lloyd J. Old, and Ira Mellman PMCID: PMC124995 Medical Sciences A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease Zhenning He and J. Eric Russell PMCID: PMC124997 The crystal structure of human CD21: Implications for Epstein–Barr virus and C3d binding Andrea E. Prota, David R. Sage, Thilo Stehle, and Joyce D. Fingeroth PMCID: PMC124999 Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancer Sanaz Memarzadeh, Katherine R. Kozak, Lisbeth Chang, Sathima Natarajan, Peter Shintaku, Srinivasa T. Reddy, and Robin Farias-Eisner PMCID: PMC125001 Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis Robert E. Fleming, John R. Ahmann, Mary C. Migas, Abdul Waheed, H. Phillip Koeffler, Hiroshi Kawabata, Robert S. Britton, Bruce R. Bacon, and William S. Sly PMCID: PMC125003 Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury Anna K. Junk, Antonios Mammis, Sean I. Savitz, Manjeet Singh, Steven Roth, Samit Malhotra, Pearl S. Rosenbaum, Anthony Cerami, Michael Brines, and Daniel M. Rosenbaum PMCID: PMC125005 Increased expression of urokinase during atherosclerotic lesion development causes arterial constriction and lumen loss, and accelerates lesion growth Mårten Falkenberg, Clifford Tom, Mary Beth DeYoung, Shan Wen, Ruth Linnemann, and David A. Dichek PMCID: PMC125007 Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease C. Dirk Keene, Cecilia M. P. Rodrigues, Tacjana Eich, Manik S. Chhabra, Clifford J. Steer, and Walter C. Low PMCID: PMC125009 KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein Murat Gunel, Maxwell S. H. Laurans, Dana Shin, Michael L. DiLuna, Jennifer Voorhees, Keith Choate, Carol Nelson-Williams, and Richard P. Lifton PMCID: PMC125011 Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-α Frederick Y. Wu, Qi-Qun Tang, Honglin Chen, Colette ApRhys, Christopher Farrell, Jianmeng Chen, Masahiro Fujimuro, M. Daniel Lane, and Gary S. Hayward PMCID: PMC125013 High diversity and rapid changeover of expressed var genes during the acute phase of Plasmodium falciparum infections in human volunteers Jennifer Peters, Elizabeth Fowler, Michelle Gatton, Nanhua Chen, Allan Saul, and Qin Cheng PMCID: PMC125014 Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia Donald A. McClain, William A. Lubas, Robert C. Cooksey, Mark Hazel, Glendon J. Parker, Dona C. Love, and John A. Hanover PMCID: PMC125016 Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop Sergei Roumiantsev, Neil P. Shah, Mercedes E. Gorre, John Nicoll, Bradley B. Brasher, Charles L. Sawyers, and Richard A. Van Etten PMCID: PMC125018 An anti-transferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells Patrick P. Ng, Jay S. Dela Cruz, David N. Sorour, James M. Stinebaugh, Seung-Uon Shin, Daniel S. Shin, Sherie L. Morrison, and Manuel L. Penichet PMCID: PMC125019 Increased peripheral expansion of naive CD4+ T cells in vivo after IL-2 treatment of patients with HIV infection Ven Natarajan, Richard A. Lempicki, Irini Sereti, Yunden Badralmaa, Joseph W. Adelsberger, Julia A. Metcalf, Darue A. Prieto, Randy Stevens, Michael W. Baseler, Joseph A. Kovacs, and H. Clifford Lane PMCID: PMC125022 Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression Yoichiro Kakugawa, Tadashi Wada, Kazunori Yamaguchi, Hideaki Yamanami, Kiyoaki Ouchi, Ikuro Sato, and Taeko Miyagi PMCID: PMC125023 NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes Jingfeng Li, Alexei Protopopov, Fuli Wang, Vera Senchenko, Valentin Petushkov, Olga Vorontsova, Lev Petrenko, Veronika Zabarovska, Olga Muravenko, Eleonora Braga, Lev Kisselev, Michael I. Lerman, Vladimir Kashuba, George Klein, Ingemar Ernberg, Claes Wahlestedt, and Eugene R. Zabarovsky PMCID: PMC125025 From the Cover:
Adipose tissue mass can be regulated through the vasculature Maria A. Rupnick, Dipak Panigrahy, Chen-Yu Zhang, Susan M. Dallabrida, Bradford B. Lowell, Robert Langer, and M. Judah Folkman PMCID: PMC125027 Microbiology Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza Gary K. Geiss, Mirella Salvatore, Terrence M. Tumpey, Victoria S. Carter, Xiuyan Wang, Christopher F. Basler, Jeffery K. Taubenberger, Roger E. Bumgarner, Peter Palese, Michael G. Katze, and Adolfo García-Sastre PMCID: PMC125029 A single Photorhabdus gene, makes caterpillars floppy (mcf), allows Escherichia coli to persist within and kill insects P. J. Daborn, N. Waterfield, C. P. Silva, C. P. Y. Au, S. Sharma, and R. H. ffrench-Constant PMCID: PMC125031 The total influenza vaccine failure of 1947 revisited: Major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic Edwin D. Kilbourne, Catherine Smith, Ian Brett, Barbara A. Pokorny, Bert Johansson, and Nancy Cox PMCID: PMC125033 Identification of quantitative trait loci controlling acute virulence in Toxoplasma gondii Chunlei Su, Daniel K. Howe, J. P. Dubey, James W. Ajioka, and L. David Sibley PMCID: PMC125035 Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis Kevin Pethe, Pablo Bifani, Hervé Drobecq, Christian Sergheraert, Anne-Sophie Debrie, Camille Locht, and Franco D. Menozzi PMCID: PMC125037 Neurobiology From the Cover:
Cerebral energetics and spiking frequency: The neurophysiological basis of fMRI Arien J. Smith, Hal Blumenfeld, Kevin L. Behar, Douglas L. Rothman, Robert G. Shulman, and Fahmeed Hyder PMCID: PMC125038 From the Cover:
Total neuroenergetics support localized brain activity: Implications for the interpretation of fMRI Fahmeed Hyder, Douglas L. Rothman, and Robert G. Shulman PMCID: PMC125040 Mistargeting hippocampal axons by expression of a truncated Eph receptor Yong Yue, Zhi-Yong Chen, Nick W. Gale, Jan Blair-Flynn, Tian-Jing Hu, Xin Yue, Margaret Cooper, David P. Crockett, George D. Yancopoulos, Lino Tessarollo, and Renping Zhou PMCID: PMC125042 Graded contribution of the Gβγ binding domains to GIRK channel activation Rona Sadja, Noga Alagem, and Eitan Reuveny PMCID: PMC125044 Sex differences in the neural basis of emotional memories Turhan Canli, John E. Desmond, Zuo Zhao, and John D. E. Gabrieli PMCID: PMC125046 Ephrin-A5 restricts topographically specific arborization in the chick retinotectal projection in vivo Takashi Sakurai, Eric Wong, Uwe Drescher, Hideaki Tanaka, and Daniel G. Jay PMCID: PMC125048 Effects of aging on central and peripheral mammalian clocks Shin Yamazaki, Marty Straume, Hajime Tei, Yoshiyuki Sakaki, Michael Menaker, and Gene D. Block PMCID: PMC125050 In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution β+-sensitive microprobe Frédéric Pain, Laurent Besret, Françoise Vaufrey, Marie-Claude Grégoire, Laurent Pinot, Philippe Gervais, Lydie Ploux, Gilles Bloch, Roland Mastrippolito, Philippe Lanièce, and Philippe Hantraye PMCID: PMC125052 α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease C. Lo Bianco, J-L. Ridet, B. L. Schneider, N. Déglon, and P. Aebischer PMCID: PMC125054 Brain monoglyceride lipase participating in endocannabinoid inactivation T. P. Dinh, D. Carpenter, F. M. Leslie, T. F. Freund, I. Katona, S. L. Sensi, S. Kathuria, and D. Piomelli PMCID: PMC125056 Reduced fear expression after lesions of the ventral hippocampus Kirsten G. Kjelstrup, Frode A. Tuvnes, Hill-Aina Steffenach, Robert Murison, Edvard I. Moser, and May-Britt Moser PMCID: PMC125057 A unified model of NMDA receptor-dependent bidirectional synaptic plasticity Harel Z. Shouval, Mark F. Bear, and Leon N Cooper PMCID: PMC125058 Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice Tony Wyss-Coray, Fengrong Yan, Amy Hsiu-Ti Lin, John D. Lambris, Jessy J. Alexander, Richard J. Quigg, and Eliezer Masliah PMCID: PMC125059 Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease Ronald B. DeMattos, Mark A. O'dell, Maia Parsadanian, Jennie W. Taylor, Judith A. K. Harmony, Kelly R. Bales, Steven M. Paul, Bruce J. Aronow, and David M. Holtzman PMCID: PMC125060 Pharmacology Tetracyclines affect prion infectivity Gianluigi Forloni, Selina Iussich, Tazeen Awan, Laura Colombo, Nadia Angeretti, Laura Girola, Ilaria Bertani, Giorgio Poli, Maria Caramelli, Maria Grazia Bruzzone, Laura Farina, Lucia Limido, Giacomina Rossi, Giorgio Giaccone, James W. Ironside, Orso Bugiani, Mario Salmona, and Fabrizio Tagliavini PMCID: PMC125061 Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics Paraskevi Giannakakou, Michel Nakano, Kyriacos C. Nicolaou, Aurora O'Brate, Jian Yu, Mikhail V. Blagosklonny, Urs F. Greber, and Tito Fojo PMCID: PMC125062 Physiology Substrate-dependent reversal of anion transport site orientation in the human red blood cell anion-exchange protein, AE1 Philip A. Knauf, Foon-Yee Law, Tze-Wah Vivian Leung, Austin U. Gehret, and Martha L. Perez PMCID: PMC125063 Plant Biology Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants Jack R. Peart, Rui Lu, Ari Sadanandom, Isabelle Malcuit, Peter Moffett, David C. Brice, Leif Schauser, Daniel A. W. Jaggard, Shunyuan Xiao, Mark J. Coleman, Max Dow, Jonathan D. G. Jones, Ken Shirasu, and David C. Baulcombe PMCID: PMC125064 Comprehensive analysis of gene expression in Nicotiana tabacum leaves acclimated to oxidative stress Eva Vranová, Sopapan Atichartpongkul, Raimundo Villarroel, Marc Van Montagu, Dirk Inzé, and Wim Van Camp PMCID: PMC125065 Sucrose-mediated transcriptional regulation of sucrose symporter activity in the phloem Matthew W. Vaughn, Gregory N. Harrington, and Daniel R. Bush PMCID: PMC125066 Tissue-specific silencing of a transgene in rice A. Klöti, X. He, I. Potrykus, T. Hohn, and J. Fütterer PMCID: PMC125067 A pentatricopeptide repeat-containing gene restores fertility to cytoplasmic male-sterile plants Stéphane Bentolila, Antonio A. Alfonso, and Maureen R. Hanson PMCID: PMC125068 C-terminal domain phosphatase-like family members (AtCPLs) differentially regulate Arabidopsis thaliana abiotic stress signaling, growth, and development Hisashi Koiwa, Adam W. Barb, Liming Xiong, Fang Li, Michael G. McCully, Byeong-ha Lee, Irina Sokolchik, Jianhua Zhu, Zhizhong Gong, Muppala Reddy, Altanbadralt Sharkhuu, Yuzuki Manabe, Shuji Yokoi, Jian-Kang Zhu, Ray A. Bressan, and Paul M. Hasegawa PMCID: PMC125069 Repression of stress-responsive genes by FIERY2, a novel transcriptional regulator in Arabidopsis Liming Xiong, Hojoung Lee, Manabu Ishitani, Yuko Tanaka, Becky Stevenson, Hisashi Koiwa, Ray A. Bressan, Paul M. Hasegawa, and Jian-Kang Zhu PMCID: PMC125070 Population Biology Mitochondrial DNA and the origins of the domestic horse Thomas Jansen, Peter Forster, Marsha A. Levine, Hardy Oelke, Matthew Hurles, Colin Renfrew, Jürgen Weber, and Klaus Olek PMCID: PMC125071 Psychology (Biological Sciences) Amplitude envelope onsets and developmental dyslexia: A new hypothesis Usha Goswami, Jennifer Thomson, Ulla Richardson, Rhona Stainthorp, Diana Hughes, Stuart Rosen, and Sophie K. Scott PMCID: PMC125072 The role of the parietal cortex in visual feature binding Keith M. Shafritz, John C. Gore, and René Marois PMCID: PMC125073 Social Sciences Social Sciences Can patient self-management help explain the SES health gradient? Dana P. Goldman and James P. Smith PMCID: PMC125075 Emergency response to a smallpox attack: The case for mass vaccination Edward H. Kaplan, David L. Craft, and Lawrence M. Wein PMCID: PMC125076 Corrections Proc Natl Acad Sci U S A. 2002 August 6; 99(16): 10941. doi: 10.1073/pnas.162346299.PMCID: PMC124889 Corrects: Liesbeth M. Veenendaal, et al. In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors. Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7866–7871. Proc Natl Acad Sci U S A. 2002 August 6; 99(16): 10941. doi: 10.1073/pnas.162346399.PMCID: PMC124890 Corrects: Andy Wong, et al. FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl. Proc Natl Acad Sci U S A. 2002 May 14; 99(10): 6684–6689. Proc Natl Acad Sci U S A. 2002 August 6; 99(16): 10941. doi: 10.1073/pnas.162295699.PMCID: PMC124891 Corrects: Alexander Grishaev, et al. CLOUDS, a protocol for deriving a molecular proton density via NMR. Proc Natl Acad Sci U S A. 2002 May 14; 99(10): 6707–6712. |
