| | This journal provides immediate access to some articles. From the Academy National Academy of Sciences endorses National Institutes of Health plan for enhanced access to research information Nicholas R. Cozzarelli, Kenneth R. Fulton, and Diane M. Sullenberger PMCID: PMC524081 Commentaries The oncogenic potential of autocrine human growth hormone in breast cancer Michael J. Waters and Becky L. Conway-Campbell PMCID: PMC524049 Smallpox: An ancient disease enters the modern era of virogenomics Grant McFadden PMCID: PMC524071 Counting the cost of a cold-blooded life: Metabolomics of cold acclimation John Browse and B. Markus Lange PMCID: PMC524045 Perspective Regional crustal thickness and precipitation in young mountain chains W. G. Ernst PMCID: PMC524060 Physical Sciences Applied Mathematics Dimensional reduction for a Bayesian filter Alexandre J. Chorin and Paul Krause PMCID: PMC524072 Elementary inequalities that involve two nonnegative vectors or functions Joel E. Cohen, J. H. B. Kemperman, and Gheorghe Zbăganu PMCID: PMC524063 A mathematical model for the scaling of turbulence Grigory Isaakovich Barenblatt and Alexandre J. Chorin PMCID: PMC524076 Chemistry From the Cover:
A rapid bioassay for single bacterial cell quantitation using bioconjugated nanoparticles Xiaojun Zhao, Lisa R. Hilliard, Shelly John Mechery, Yanping Wang, Rahul P. Bagwe, Shouguang Jin, and Weihong Tan PMCID: PMC524056 Geology Ringwoodite lamellae in olivine: Clues to olivine–ringwoodite phase transition mechanisms in shocked meteorites and subducting slabs Ming Chen, Ahmed El Goresy, and Philippe Gillet PMCID: PMC524059 Physics Experimental test of Hatano and Sasa's nonequilibrium steady-state equality E. H. Trepagnier, C. Jarzynski, F. Ritort, G. E. Crooks, C. J. Bustamante, and J. Liphardt PMCID: PMC524055 Biological Sciences Applied Biological Sciences Wolbachia-induced cytoplasmic incompatibility as a means for insect pest population control Sofia Zabalou, Markus Riegler, Marianna Theodorakopoulou, Christian Stauffer, Charalambos Savakis, and Kostas Bourtzis PMCID: PMC524042 Biochemistry INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Arthur L. Horwich Tinsley H. Davis PMCID: PMC524080 INAUGURAL ARTICLE by a Recently Elected Academy Member: Substrate polypeptide presents a load on the apical domains of the chaperonin GroEL Fumihiro Motojima, Charu Chaudhry, Wayne A. Fenton, George W. Farr, and Arthur L. Horwich PMCID: PMC523455 Targeting a binding pocket within the trimer-of-hairpins: Small-molecule inhibition of viral fusion Christopher Cianci, David R. Langley, Douglas D. Dischino, Yaxiong Sun, Kuo-Long Yu, Anne Stanley, Julia Roach, Zhufang Li, Richard Dalterio, Richard Colonno, Nicholas A. Meanwell, and Mark Krystal PMCID: PMC523459 Crystal structure of γ-glutamylcysteine synthetase: Insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis Takao Hibi, Hiroshi Nii, Toru Nakatsu, Akira Kimura, Hiroaki Kato, Jun Hiratake, and Jun'ichi Oda PMCID: PMC523444 Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4 Loretta L. Collins, Yi-Fen Lee, Cynthia A. Heinlein, Ning-Chun Liu, Yei-Tsung Chen, Chih-Rong Shyr, Charles K. Meshul, Hideo Uno, Kenneth A. Platt, and Chawnshang Chang PMCID: PMC524065 Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor Alessandro Vannini, Cinzia Volpari, Gessica Filocamo, Elena Caroli Casavola, Mirko Brunetti, Debora Renzoni, Prasun Chakravarty, Chantal Paolini, Raffaele De Francesco, Paola Gallinari, Christian Steinkühler, and Stefania Di Marco PMCID: PMC524051 Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease Yohei Kirino, Takehiro Yasukawa, Shigeo Ohta, Shigeo Akira, Kaisuke Ishihara, Kimitsuna Watanabe, and Tsutomu Suzuki PMCID: PMC524061 Biophysics Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin Seiji Takeuchi, Wengeng Zhang, Kazumasa Wakamatsu, Shosuke Ito, Vincent J. Hearing, Kenneth H. Kraemer, and Douglas E. Brash PMCID: PMC524044 Shape control through molecular segregation in giant surfactant aggregates Monique Dubois, Vladimir Lizunov, Annette Meister, Thadeus Gulik-Krzywicki, Jean Marc Verbavatz, Emile Perez, Joshua Zimmerberg, and Thomas Zemb PMCID: PMC523443 Three-body interactions improve the prediction of rate and mechanism in protein folding models M. R. Ejtehadi, S. P. Avall, and S. S. Plotkin PMCID: PMC524050 The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis Sagar D. Khare, Michael Caplow, and Nikolay V. Dokholyan PMCID: PMC524068 Cell Biology Cell division and cell survival in the absence of survivin Dun Yang, Alana Welm, and J. Michael Bishop PMCID: PMC524069 Upstream binding factor association induces large-scale chromatin decondensation Danyang Chen, Andrew S. Belmont, and Sui Huang PMCID: PMC524054 RNA polymerase I remains intact without subunit exchange through multiple rounds of transcription in Saccharomyces cerevisiae David A. Schneider and Masayasu Nomura PMCID: PMC524078 Developmental Biology Ciona intestinalis Hox gene cluster: Its dispersed structure and residual colinear expression in development Tetsuro Ikuta, Natsue Yoshida, Nori Satoh, and Hidetoshi Saiga PMCID: PMC524048 Ecology Forecast and control of epidemics in a globalized world L. Hufnagel, D. Brockmann, and T. Geisel PMCID: PMC524041 Cross-scale interactions, nonlinearities, and forecasting catastrophic events Debra P. C. Peters, Roger A. Pielke, Sr., Brandon T. Bestelmeyer, Craig D. Allen, Stuart Munson-McGee, and Kris M. Havstad PMCID: PMC523446 Ammonia-oxidizing bacteria respond to multifactorial global change Hans-Peter Horz, Adrian Barbrook, Christopher B. Field, and Brendan J. M. Bohannan PMCID: PMC524064 Genetics Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3 Christopher M. Seabury, Rodney L. Honeycutt, Alejandro P. Rooney, Natalie D. Halbert, and James N. Derr PMCID: PMC524052 Molecular triangulation: Bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease Michael Krauthammer, Charles A. Kaufmann, T. Conrad Gilliam, and Andrey Rzhetsky PMCID: PMC523448 Immunology IL-15/IL-15Rα-mediated avidity maturation of memory CD8+ T cells SangKon Oh, Liyanage P. Perera, Donald S. Burke, Thomas A. Waldmann, and Jay A. Berzofsky PMCID: PMC524066 Medical Sciences Development of a polyclonal antiserum for the detection of the isoforms of the receptors for human growth hormone-releasing hormone on tumors Gabor L. Toller, Judit E. Horvath, Andrew V. Schally, Gabor Halmos, Jozsef L. Varga, Kate Groot, David Chism, and Marta Zarandi PMCID: PMC524040 From the Cover:
Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone Svetlana Mukhina, Hichem C. Mertani, Ke Guo, Kok-Onn Lee, Peter D. Gluckman, and Peter E. Lobie PMCID: PMC524067 Bacteriolytic therapy can generate a potent immune response against experimental tumors Nishant Agrawal, Chetan Bettegowda, Ian Cheong, Jean-Francois Geschwind, Charles G. Drake, Edward L. Hipkiss, Mitsuaki Tatsumi, Long H. Dang, Luis A. Diaz, Jr., Martin Pomper, Mohammad Abusedera, Richard L. Wahl, Kenneth W. Kinzler, Shibin Zhou, David L. Huso, and Bert Vogelstein PMCID: PMC523456 Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial Nan Chiang, Edmund A. Bermudez, Paul M. Ridker, Shelley Hurwitz, and Charles N. Serhan PMCID: PMC523452 Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice Timothy S. Fenske, Gina Pengue, Vikram Mathews, Piia T. Hanson, Sarah E. Hamm, Noor Riaz, and Timothy A. Graubert PMCID: PMC524043 Microbiology From the Cover:
The host response to smallpox: Analysis of the gene expression program in peripheral blood cells in a nonhuman primate model Kathleen H. Rubins, Lisa E. Hensley, Peter B. Jahrling, Adeline R. Whitney, Thomas W. Geisbert, John W. Huggins, Art Owen, James W. LeDuc, Patrick O. Brown, and David A. Relman PMCID: PMC523453 From the Cover:
Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox Peter B. Jahrling, Lisa E. Hensley, Mark J. Martinez, James W. LeDuc, Kathleen H. Rubins, David A. Relman, and John W. Huggins PMCID: PMC523454 Neuroscience The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development Robert Lu, Houping Wang, Zhe Liang, Li Ku, William T. O'Donnell, Wen Li, Stephen T. Warren, and Yue Feng PMCID: PMC524058 Visualization of a functionally enhanced GFP-tagged galanin R2 receptor in PC12 cells: Constitutive and ligand-induced internalization Sheng Xia, Svend Kjær, Kang Zheng, Ping-Sheng Hu, Li Bai, Jun-Yong Jia, Rudolf Rigler, Aladdin Pramanik, Tao Xu, Tomas Hökfelt, and Zhi-Qing David Xu PMCID: PMC524062 Nonvesicular release of acetylcholine is required for axon targeting in the Drosophila visual system Hong Yang and Sam Kunes PMCID: PMC524039 Deletion of the synaptic protein interaction site of the N-type (CaV2.2) calcium channel inhibits secretion in mouse pheochromocytoma cells Amy B. Harkins, Anne L. Cahill, James F. Powers, Arthur S. Tischler, and Aaron P. Fox PMCID: PMC524046 Pharmacology Regulation of the endogenous VEGF-A gene by exogenous designed regulatory proteins Kiyoshi Tachikawa, Oliver Schröder, Gerhard Frey, Steven P. Briggs, and Takashi Sera PMCID: PMC523457 Physiology Transforming growth factor β-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation Joseph M. Scandura, Piernicola Boccuni, Joan Massagué, and Stephen D. Nimer PMCID: PMC524079 Multiple sequences in the C terminus of MaxiK channels are involved in expression, movement to the cell surface, and apical localization Sang-Ho Kwon and William B. Guggino PMCID: PMC524057 Plant Biology From the Cover:
A prominent role for the CBF cold response pathway in configuring the low-temperature metabolome of Arabidopsis Daniel Cook, Sarah Fowler, Oliver Fiehn, and Michael F. Thomashow PMCID: PMC524070 Engineering high-level aluminum tolerance in barley with the ALMT1 gene Emmanuel Delhaize, Peter R. Ryan, Diane M. Hebb, Yoko Yamamoto, Takayuki Sasaki, and Hideaki Matsumoto PMCID: PMC524075 Nucleotide diversity and linkage disequilibrium in loblolly pine Garth R. Brown, Geoffrey P. Gill, Robert J. Kuntz, Charles H. Langley, and David B. Neale PMCID: PMC524047 Population Biology Most species are not driven to extinction before genetic factors impact them Derek Spielman, Barry W. Brook, and Richard Frankham PMCID: PMC524053 Psychology Left insula activation: A marker for language attainment in bilinguals Michael W. L. Chee, Chun Siong Soon, Hwee Ling Lee, and Christophe Pallier PMCID: PMC523445 Corrections Proc Natl Acad Sci U S A. 2004 October 19; 101(42): 15271. doi: 10.1073/pnas.0406713101.PMCID: PMC524073 Corrects: Luiz F. Zerbini, et al. NF-κB-mediated repression of growth arrest- and DNA-damage-inducible proteins 45α and γ is essential for cancer cell survival. Proc Natl Acad Sci U S A. 2004 September 14; 101(37): 13618–13623. Proc Natl Acad Sci U S A. 2004 October 19; 101(42): 15271. doi: 10.1073/pnas.0406730101.PMCID: PMC524077 Corrects: Colin A. Bill, et al. Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration. Proc Natl Acad Sci U S A. 2004 July 27; 101(30): 11135–11140. Retraction Proc Natl Acad Sci U S A. 2004 October 19; 101(42): 15271. doi: 10.1073/pnas.0406725101.PMCID: PMC524074 Retracts: Jeffrey R. Martens, et al. Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy. Proc Natl Acad Sci U S A. 1998 March 3; 95(5): 2664–2669. |
