| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1775–1776. doi: 10.1073/iti0608105.PMCID: PMC2538836 Commentaries Biofortified and bioavailable: The gold standard for plant-based diets Jeeyon Jeong and Mary Lou Guerinot Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1777–1778. doi: 10.1073/pnas.0712330105.PMCID: PMC2538837 Macromolecular structures without crystals Robert M. Glaeser Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1779–1780. doi: 10.1073/pnas.0800032105.PMCID: PMC2538838 Insects take a bigger bite out of plants in a warmer, higher carbon dioxide world Evan H. DeLucia, Clare L. Casteel, Paul D. Nabity, and Bridget F. O'Neill Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1781–1782. doi: 10.1073/pnas.0712056105.PMCID: PMC2538839 Perspective INAUGURAL ARTICLE by a Recently Elected Academy Member: Tipping elements in the Earth's climate system Timothy M. Lenton, Hermann Held, Elmar Kriegler, Jim W. Hall, Wolfgang Lucht, Stefan Rahmstorf, and Hans Joachim Schellnhuber Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1786–1793. doi: 10.1073/pnas.0705414105.PMCID: PMC2538841 Profile Profile of Hans Joachim Schellnhuber Kaspar Mossman Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1783–1785. doi: 10.1073/pnas.0800554105.PMCID: PMC2538840 Physical Sciences Chemistry Conformational polymorphism in a heteromolecular single crystal leads to concerted movement akin to collective rack-and-pinion gears at the molecular level Anatoliy N. Sokolov, Dale C. Swenson, and Leonard R. MacGillivray Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1794–1797. doi: 10.1073/pnas.0706117105.PMCID: PMC2542860 Plasmonic engineering of singlet oxygen generation Yongxia Zhang, Kadir Aslan, Michael J. R. Previte, and Chris D. Geddes Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1798–1802. doi: 10.1073/pnas.0709501105.PMCID: PMC2538842 The nature of O2 activation by the ethylene-forming enzyme 1-aminocyclopropane-1-carboxylic acid oxidase Liviu M. Mirica and Judith P. Klinman Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1814–1819. doi: 10.1073/pnas.0711626105.PMCID: PMC2538845 Mathematics Manifold parametrizations by eigenfunctions of the Laplacian and heat kernels Peter W. Jones, Mauro Maggioni, and Raanan Schul Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1803–1808. doi: 10.1073/pnas.0710175104.PMCID: PMC2538843 Physics Controlling energy transfer between multiple dopants within a single nanoparticle Jeffrey R. DiMaio, Clément Sabatier, Baris Kokuoz, and John Ballato Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1809–1813. doi: 10.1073/pnas.0711638105.PMCID: PMC2538844 Sustainability Science INAUGURAL ARTICLE by a Recently Elected Academy Member: Tipping elements in the Earth's climate system Timothy M. Lenton, Hermann Held, Elmar Kriegler, Jim W. Hall, Wolfgang Lucht, Stefan Rahmstorf, and Hans Joachim Schellnhuber Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1786–1793. doi: 10.1073/pnas.0705414105.PMCID: PMC2538841 Biological Sciences Biochemistry The nature of O2 activation by the ethylene-forming enzyme 1-aminocyclopropane-1-carboxylic acid oxidase Liviu M. Mirica and Judith P. Klinman Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1814–1819. doi: 10.1073/pnas.0711626105.PMCID: PMC2538845 Molecular basis for LDL receptor recognition by PCSK9 Hyock Joo Kwon, Thomas A. Lagace, Markey C. McNutt, Jay D. Horton, and Johann Deisenhofer Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1820–1825. doi: 10.1073/pnas.0712064105.PMCID: PMC2538846 RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli Brian P. Anton, Lana Saleh, Jack S. Benner, Elisabeth A. Raleigh, Simon Kasif, and Richard J. Roberts Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1826–1831. doi: 10.1073/pnas.0708608105.PMCID: PMC2538847 Structural identification of the pathway of long-range communication in an allosteric enzyme Prafull S. Gandhi, Zhiwei Chen, F. Scott Mathews, and Enrico Di Cera Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1832–1837. doi: 10.1073/pnas.0710894105.PMCID: PMC2538848 Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor Jieyi Wang, Lora A. Tucker, Jason Stavropoulos, Qian Zhang, Yi-Chun Wang, Gail Bukofzer, Amanda Niquette, Jonathan A. Meulbroek, David M. Barnes, Jianwei Shen, Jennifer Bouska, Cherrie Donawho, George S. Sheppard, and Randy L. Bell Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1838–1843. doi: 10.1073/pnas.0708766105.PMCID: PMC2538849 Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase Matthew P. Blakeley, Federico Ruiz, Raul Cachau, Isabelle Hazemann, Flora Meilleur, Andre Mitschler, Stephan Ginell, Pavel Afonine, Oscar N. Ventura, Alexandra Cousido-Siah, Michael Haertlein, Andrzej Joachimiak, Dean Myles, and Alberto Podjarny Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1844–1848. doi: 10.1073/pnas.0711659105.PMCID: PMC2538850 The kernel energy method of quantum mechanical approximation carried to fourth-order terms Lulu Huang, Lou Massa, and Jerome Karle Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1849–1854. doi: 10.1073/pnas.0711297105.PMCID: PMC2538851 Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface Boriana Marintcheva, Assen Marintchev, Gerhard Wagner, and Charles C. Richardson Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1855–1860. doi: 10.1073/pnas.0711919105.PMCID: PMC2538852 Structure and mechanism of IFN-γ antagonism by an orthopoxvirus IFN-γ-binding protein Anthony A. Nuara, Leigh J. Walter, Naomi J. Logsdon, Sung Il Yoon, Brandi C. Jones, Jill M. Schriewer, R. Mark Buller, and Mark R. Walter Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1861–1866. doi: 10.1073/pnas.0705753105.PMCID: PMC2542861 Biophysics From the Cover: Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction Xing Zhang, Ethan Settembre, Chen Xu, Philip R. Dormitzer, Richard Bellamy, Stephen C. Harrison, and Nikolaus Grigorieff Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1867–1872. doi: 10.1073/pnas.0711623105.PMCID: PMC2542862 Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2 Jesko Koehnke, Xiangshu Jin, Elaine C. Budreck, Shoshana Posy, Peter Scheiffele, Barry Honig, and Lawrence Shapiro Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1873–1878. doi: 10.1073/pnas.0711701105.PMCID: PMC2538853 Structural changes in the Mn4Ca cluster and the mechanism of photosynthetic water splitting Yulia Pushkar, Junko Yano, Kenneth Sauer, Alain Boussac, and Vittal K. Yachandra Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1879–1884. doi: 10.1073/pnas.0707092105.PMCID: PMC2542863 Atomic force microscopy reveals parallel mechanical unfolding pathways of T4 lysozyme: Evidence for a kinetic partitioning mechanism Qing Peng and Hongbin Li Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1885–1890. doi: 10.1073/pnas.0706775105.PMCID: PMC2538854 Use of 13Cα chemical shifts for accurate determination of β-sheet structures in solution Jorge A. Vila, Yelena A. Arnautova, and Harold A. Scheraga Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1891–1896. doi: 10.1073/pnas.0711022105.PMCID: PMC2542864 Gene expression dynamics in the macrophage exhibit criticality Matti Nykter, Nathan D. Price, Maximino Aldana, Stephen A. Ramsey, Stuart A. Kauffman, Leroy E. Hood, Olli Yli-Harja, and Ilya Shmulevich Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1897–1900. doi: 10.1073/pnas.0711525105.PMCID: PMC2538855 Cell Biology From the Cover: Cytoplasmic BKCa channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons Thomas J. Bell, Kevin Y. Miyashiro, Jai-Yoon Sul, Ronald McCullough, Peter T. Buckley, Jeanine Jochems, David F. Meaney, Phil Haydon, Charles Cantor, Thomas D. Parsons, and James Eberwine Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1901–1906. doi: 10.1073/pnas.0711796105.PMCID: PMC2538856 Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process Raymond Pfau, Alexandros Tzatsos, Sotirios C. Kampranis, Oksana B. Serebrennikova, Susan E. Bear, and Philip N. Tsichlis Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1907–1912. doi: 10.1073/pnas.0711865105.PMCID: PMC2538857 Emergent decision-making in biological signal transduction networks Tomáš Helikar, John Konvalina, Jack Heidel, and Jim A. Rogers Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1913–1918. doi: 10.1073/pnas.0705088105.PMCID: PMC2538858 Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing Zhao-Qiu Wu and Xiaoqi Liu Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1919–1924. doi: 10.1073/pnas.0712063105.PMCID: PMC2538859 Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway Adriane Regina Todeschini, Jose Nilson Dos Santos, Kazuko Handa, and Sen-itiroh Hakomori Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1925–1930. doi: 10.1073/pnas.0709619104.PMCID: PMC2538860 Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network Olivier C. Pertz, Yingchun Wang, Feng Yang, Wei Wang, Laurie J. Gay, Marina A. Gristenko, Therese R. Clauss, David J. Anderson, Tao Liu, Kenneth J. Auberry, David G. Camp, II, Richard D. Smith, and Richard L. Klemke Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1931–1936. doi: 10.1073/pnas.0706545105.PMCID: PMC2542865 A role for caspase 2 and PIDD in the process of p53-mediated apoptosis Nicole Baptiste-Okoh, Anthony M. Barsotti, and Carol Prives Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1937–1942. doi: 10.1073/pnas.0711800105.PMCID: PMC2538861 Enterococcus faecalis from newborn babies regulate endogenous PPARγ activity and IL-10 levels in colonic epithelial cells Alexandra Are, Linda Aronsson, Shugui Wang, Gediminas Greicius, Yuan Kun Lee, Jan-Åke Gustafsson, Sven Pettersson, and Velmurugesan Arulampalam Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1943–1948. doi: 10.1073/pnas.0711734105.PMCID: PMC2538862 Developmental Biology Dicer-dependent pathways regulate chondrocyte proliferation and differentiation Tatsuya Kobayashi, Jun Lu, Bradley S. Cobb, Stephen J. Rodda, Andrew P. McMahon, Ernestina Schipani, Matthias Merkenschlager, and Henry M. Kronenberg Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1949–1954. doi: 10.1073/pnas.0707900105.PMCID: PMC2538863 Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development Frances A. High, Min Min Lu, Warren S. Pear, Kathleen M. Loomes, Klaus H. Kaestner, and Jonathan A. Epstein Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1955–1959. doi: 10.1073/pnas.0709663105.PMCID: PMC2538864 Ecology From the Cover: Sharply increased insect herbivory during the Paleocene–Eocene Thermal Maximum Ellen D. Currano, Peter Wilf, Scott L. Wing, Conrad C. Labandeira, Elizabeth C. Lovelock, and Dana L. Royer Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1960–1964. doi: 10.1073/pnas.0708646105.PMCID: PMC2538865 Influence of ocean winds on the pelagic ecosystem in upwelling regions Ryan R. Rykaczewski and David M. Checkley, Jr Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1965–1970. doi: 10.1073/pnas.0711777105.PMCID: PMC2538866 Increased plant growth from nitrogen addition should conserve phosphorus in terrestrial ecosystems Michael P. Perring, Lars O. Hedin, Simon A. Levin, Megan McGroddy, and Claire de Mazancourt Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1971–1976. doi: 10.1073/pnas.0711618105.PMCID: PMC2542866 Coexisting generalist herbivores occupy unique nutritional feeding niches Spencer T. Behmer and Anthony Joern Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1977–1982. doi: 10.1073/pnas.0711870105.PMCID: PMC2538867 Evolution From the Cover: Discovery of a rare arboreal forest-dwelling flying reptile (Pterosauria, Pterodactyloidea) from China Xiaolin Wang, Alexander W. A. Kellner, Zhonghe Zhou, and Diogenes de Almeida Campos Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1983–1987. doi: 10.1073/pnas.0707728105.PMCID: PMC2538868 Paternal effects on offspring fitness in a multimale primate society M. J. E. Charpentier, R. C. Van Horn, J. Altmann, and S. C. Alberts Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1988–1992. doi: 10.1073/pnas.0711219105.PMCID: PMC2538869 Extraordinary intraspecific diversity in oyster sperm bindin G. W. Moy, S. A. Springer, S. L. Adams, W. J. Swanson, and V. D. Vacquier Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1993–1998. doi: 10.1073/pnas.0711862105.PMCID: PMC2538870 Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei De-Hua Lai, Hassan Hashimi, Zhao-Rong Lun, Francisco J. Ayala, and Julius Lukeš Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1999–2004. doi: 10.1073/pnas.0711799105.PMCID: PMC2538871 Genetics Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina Wesley D. Swingley, Min Chen, Patricia C. Cheung, Amber L. Conrad, Liza C. Dejesa, Jicheng Hao, Barbara M. Honchak, Lauren E. Karbach, Ahmet Kurdoglu, Surobhi Lahiri, Stephen D. Mastrian, Hideaki Miyashita, Lawrence Page, Pushpa Ramakrishna, Soichirou Satoh, W. Matthew Sattley, Yuichiro Shimada, Heather L. Taylor, Tatsuya Tomo, Tohru Tsuchiya, Zi T. Wang, Jason Raymond, Mamoru Mimuro, Robert E. Blankenship, and Jeffrey W. Touchman Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2005–2010. doi: 10.1073/pnas.0709772105.PMCID: PMC2538872 Immunology Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation Maria I. Lioudyno, J. Ashot Kozak, Aubin Penna, Olga Safrina, Shenyuan L. Zhang, Debasish Sen, Jack Roos, Kenneth A. Stauderman, and Michael D. Cahalan Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2011–2016. doi: 10.1073/pnas.0706122105.PMCID: PMC2538873 A role for leptin in sustaining lymphopoiesis and myelopoiesis Kate Claycombe, Louis E. King, and Pamela J. Fraker Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2017–2021. doi: 10.1073/pnas.0712053105.PMCID: PMC2538874 Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice Ling Xue, Hector Nolla, Akira Suzuki, Tak W. Mak, and Astar Winoto Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2022–2027. doi: 10.1073/pnas.0712059105.PMCID: PMC2538875 Natural glucocorticoids induce expansion of all developmental stages of murine bone marrow granulocytes without inhibiting function Mark D. Trottier, Matthew M. Newsted, Louis E. King, and Pamela J. Fraker Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2028–2033. doi: 10.1073/pnas.0712003105.PMCID: PMC2538876 Epitope-specific TCRβ repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides Nicole L. La Gruta, Paul G. Thomas, Andrew I. Webb, Michelle A. Dunstone, Tania Cukalac, Peter C. Doherty, Anthony W. Purcell, Jamie Rossjohn, and Stephen J. Turner Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2034–2039. doi: 10.1073/pnas.0711682102.PMCID: PMC2538877 Structure and specificity of lamprey monoclonal antibodies Brantley R. Herrin, Matthew N. Alder, Kenneth H. Roux, Christina Sina, Götz R. A. Ehrhardt, Jeremy A. Boydston, Charles L. Turnbough, Jr, and Max D. Cooper Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2040–2045. doi: 10.1073/pnas.0711619105.PMCID: PMC2542867 Medical Sciences Aerosol immunization with NYVAC and MVA vectored vaccines is safe, simple, and immunogenic Max Corbett, Willy M. Bogers, Jonathan L. Heeney, Stefan Gerber, Christian Genin, Arnaud Didierlaurent, Herman Oostermeijer, Rob Dubbes, Gerco Braskamp, Stéphanie Lerondel, Carmen E. Gomez, Mariano Esteban, Ralf Wagner, Ivanella Kondova, Petra Mooij, Sunita Balla-Jhagjhoorsingh, Niels Beenhakker, Gerrit Koopman, Sjoerd van der Burg, Jean-Pierre Kraehenbuhl, and Alain Le Pape Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2046–2051. doi: 10.1073/pnas.0705191105.PMCID: PMC2538878 Lithium delays progression of amyotrophic lateral sclerosis Francesco Fornai, Patrizia Longone, Luisa Cafaro, Olga Kastsiuchenka, Michela Ferrucci, Maria Laura Manca, Gloria Lazzeri, Alida Spalloni, Natascia Bellio, Paola Lenzi, Nicola Modugno, Gabriele Siciliano, Ciro Isidoro, Luigi Murri, Stefano Ruggieri, and Antonio Paparelli Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2052–2057. doi: 10.1073/pnas.0708022105.PMCID: PMC2538879 From the Cover: Microneedles permit transdermal delivery of a skin-impermeant medication to humans Daniel P. Wermeling, Stan L. Banks, David A. Hudson, Harvinder S. Gill, Jyoti Gupta, Mark R. Prausnitz, and Audra L. Stinchcomb Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2058–2063. doi: 10.1073/pnas.0710355105.PMCID: PMC2538880 PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model Ming Du, Xiaoli Liu, Ellen M. Welch, Samit Hirawat, Stuart W. Peltz, and David M. Bedwell Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2064–2069. doi: 10.1073/pnas.0711795105.PMCID: PMC2538881 The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP Cai-Hong Yun, Kristen E. Mengwasser, Angela V. Toms, Michele S. Woo, Heidi Greulich, Kwok-Kin Wong, Matthew Meyerson, and Michael J. Eck Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2070–2075. doi: 10.1073/pnas.0709662105.PMCID: PMC2538882 Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia Su-Jiang Zhang, Li-Yuan Ma, Qiu-Hua Huang, Guo Li, Bai-Wei Gu, Xiao-Dong Gao, Jing-Yi Shi, Yue-Ying Wang, Li Gao, Xun Cai, Rui-Bao Ren, Jiang Zhu, Zhu Chen, and Sai-Juan Chen Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2076–2081. doi: 10.1073/pnas.0711824105.PMCID: PMC2538883 Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice Fredrik Johansson, Farah Kramer, Shelley Barnhart, Jenny E. Kanter, Tomas Vaisar, Rachel D. Merrill, Linda Geng, Kazuhiro Oka, Lawrence Chan, Alan Chait, Jay W. Heinecke, and Karin E. Bornfeldt Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2082–2087. doi: 10.1073/pnas.0709958105.PMCID: PMC2538884 The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development Paul G. Matteson, Jigar Desai, Ron Korstanje, Gloria Lazar, Tanya E. Borsuk, Jarod Rollins, Sindhuja Kadambi, Jamie Joseph, Taslima Rahman, Jason Wink, Rym Benayed, Beverly Paigen, and James H. Millonig Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2088–2093. doi: 10.1073/pnas.0705657105.PMCID: PMC2538885 Liver X receptor β (LXRβ): A link between β-sitosterol and amyotrophic lateral sclerosis–Parkinson's dementia Hyun-Jin Kim, Xiaotang Fan, Chiara Gabbi, Konstantin Yakimchuk, Paolo Parini, Margaret Warner, and Jan-Åke Gustafsson Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2094–2099. doi: 10.1073/pnas.0711599105.PMCID: PMC2542868 A vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4+ T cell depletion in SHIV-infected macaques Vincent Vieillard, Roger Le Grand, Jean Dausset, and Patrice Debré Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2100–2104. doi: 10.1073/pnas.0711629105.PMCID: PMC2542869 A causal role for ERG in neoplastic transformation of prostate epithelium Olga Klezovitch, Michael Risk, Ilsa Coleman, Jared M. Lucas, Manda Null, Lawrence D. True, Peter S. Nelson, and Valeri Vasioukhin Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2105–2110. doi: 10.1073/pnas.0711711105.PMCID: PMC2538886 Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure Jian-Fu Chen, Elizabeth P. Murchison, Ruhang Tang, Thomas E. Callis, Mariko Tatsuguchi, Zhongliang Deng, Mauricio Rojas, Scott M. Hammond, Michael D. Schneider, Craig H. Selzman, Gerhard Meissner, Cam Patterson, Gregory J. Hannon, and Da-Zhi Wang Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2111–2116. doi: 10.1073/pnas.0710228105.PMCID: PMC2542870 Microbiology Symbiotic gut microbes modulate human metabolic phenotypes Min Li, Baohong Wang, Menghui Zhang, Mattias Rantalainen, Shengyue Wang, Haokui Zhou, Yan Zhang, Jian Shen, Xiaoyan Pang, Meiling Zhang, Hua Wei, Yu Chen, Haifeng Lu, Jian Zuo, Mingming Su, Yunping Qiu, Wei Jia, Chaoni Xiao, Leon M. Smith, Shengli Yang, Elaine Holmes, Huiru Tang, Guoping Zhao, Jeremy K. Nicholson, Lanjuan Li, and Liping Zhao Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2117–2122. doi: 10.1073/pnas.0712038105.PMCID: PMC2538887 Superinfection as a driver of genomic diversification in antigenically variant pathogens James E. Futse, Kelly A. Brayton, Michael J. Dark, Donald P. Knowles, Jr., and Guy H. Palmer Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2123–2127. doi: 10.1073/pnas.0710333105.PMCID: PMC2538888 The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features Henning Seedorf, W. Florian Fricke, Birgit Veith, Holger Brüggemann, Heiko Liesegang, Axel Strittmatter, Marcus Miethke, Wolfgang Buckel, Julia Hinderberger, Fuli Li, Christoph Hagemeier, Rudolf K. Thauer, and Gerhard Gottschalk Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2128–2133. doi: 10.1073/pnas.0711093105.PMCID: PMC2542871 A moderately thermophilic ammonia-oxidizing crenarchaeote from a hot spring Roland Hatzenpichler, Elena V. Lebedeva, Eva Spieck, Kilian Stoecker, Andreas Richter, Holger Daims, and Michael Wagner Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2134–2139. doi: 10.1073/pnas.0708857105.PMCID: PMC2538889 Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes Erika Assarsson, Jason A. Greenbaum, Magnus Sundström, Lana Schaffer, Jennifer A. Hammond, Valerie Pasquetto, Carla Oseroff, R. Curtis Hendrickson, Elliot J. Lefkowitz, David C. Tscharke, John Sidney, Howard M. Grey, Steven R. Head, Bjoern Peters, and Alessandro Sette Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2140–2145. doi: 10.1073/pnas.0711573105.PMCID: PMC2542872 Translation initiation factor a/eIF2(-γ) counteracts 5′ to 3′ mRNA decay in the archaeon Sulfolobus solfataricus David Hasenöhrl, Tania Lombo, Vladimir Kaberdin, Paola Londei, and Udo Bläsi Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2146–2150. doi: 10.1073/pnas.0708894105.PMCID: PMC2538890 Centromere anatomy in the multidrug-resistant pathogen Enterococcus faecium Andrew Derome, Christian Hoischen, Malte Bussiek, Ruth Grady, Malgorzata Adamczyk, Barbara Kędzierska, Stephan Diekmann, Daniela Barillà, and Finbarr Hayes Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2151–2156. doi: 10.1073/pnas.0704681105.PMCID: PMC2538891 Neuroscience The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels Curtis F. Barrett and Richard W. Tsien Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2157–2162. doi: 10.1073/pnas.0710501105.PMCID: PMC2538892 Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in l-DOPA treatment of an animal model of Parkinsonism Xiaoqun Zhang, Per E. Andren, Paul Greengard, and Per Svenningsson Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2163–2168. doi: 10.1073/pnas.0711839105.PMCID: PMC2538893 Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons Hongmei Li, Yingbei Chen, Adrienne F. Jones, Richard H. Sanger, Leon P. Collis, Richard Flannery, Ewan C. McNay, Tingxi Yu, Robert Schwarzenbacher, Blaise Bossy, Ella Bossy-Wetzel, Michael V. L. Bennett, Marc Pypaert, John A. Hickman, Peter J. S. Smith, J. Marie Hardwick, and Elizabeth A. Jonas Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2169–2174. doi: 10.1073/pnas.0711647105.PMCID: PMC2542873 Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons Mitsuko Hayashi, Andrea Raimondi, Eileen O'Toole, Summer Paradise, Chiara Collesi, Ottavio Cremona, Shawn M. Ferguson, and Pietro De Camilli Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2175–2180. doi: 10.1073/pnas.0712171105.PMCID: PMC2538894 Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation Saul L. Miller, Kim Celone, Kristina DePeau, Eli Diamond, Bradford C. Dickerson, Dorene Rentz, Maija Pihlajamäki, and Reisa A. Sperling Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2181–2186. doi: 10.1073/pnas.0706818105.PMCID: PMC2538895 Robust but delayed thalamocortical activation of dendritic-targeting inhibitory interneurons Zhenjun Tan, Hang Hu, Z. Josh Huang, and Ariel Agmon Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2187–2192. doi: 10.1073/pnas.0710628105.PMCID: PMC2538896 Pharmacology Commensal microbiota is fundamental for the development of inflammatory pain F. A. Amaral, D. Sachs, V. V. Costa, C. T. Fagundes, D. Cisalpino, T. M. Cunha, S. H. Ferreira, F. Q. Cunha, T. A. Silva, J. R. Nicoli, L. Q. Vieira, D. G. Souza, and M. M. Teixeira Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2193–2197. doi: 10.1073/pnas.0711891105.PMCID: PMC2538897 Physiology Remodeling of ryanodine receptor complex causes “leaky” channels: A molecular mechanism for decreased exercise capacity Andrew M. Bellinger, Steven Reiken, Miroslav Dura, Peter W. Murphy, Shi-Xian Deng, Donald W. Landry, David Nieman, Stephan E. Lehnart, Mahendranauth Samaru, Alain LaCampagne, and Andrew R. Marks Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2198–2202. doi: 10.1073/pnas.0711074105.PMCID: PMC2538898 TASK channel deletion in mice causes primary hyperaldosteronism Lucinda A. Davies, Changlong Hu, Nick A. Guagliardo, Neil Sen, Xiangdong Chen, Edmund M. Talley, Robert M. Carey, Douglas A. Bayliss, and Paula Q. Barrett Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2203–2208. doi: 10.1073/pnas.0712000105.PMCID: PMC2538899 When pliers become fingers in the monkey motor system M. A. Umiltà, L. Escola, I. Intskirveli, F. Grammont, M. Rochat, F. Caruana, A. Jezzini, V. Gallese, and G. Rizzolatti Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2209–2213. doi: 10.1073/pnas.0705985105.PMCID: PMC2538900 Plant Biology Resetting of FLOWERING LOCUS C expression after epigenetic repression by vernalization Candice C. Sheldon, Melissa J. Hills, Clare Lister, Caroline Dean, Elizabeth S. Dennis, and W. James Peacock Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2214–2219. doi: 10.1073/pnas.0711453105.PMCID: PMC2542874 Signaling of cell fate determination by the TPD1 small protein and EMS1 receptor kinase Gengxiang Jia, Xiaodong Liu, Heather A. Owen, and Dazhong Zhao Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2220–2225. doi: 10.1073/pnas.0708795105.PMCID: PMC2538901 Self-assembly of the plant cell wall requires an extensin scaffold Maura C. Cannon, Kimberly Terneus, Qi Hall, Li Tan, Yumei Wang, Benjamin L. Wegenhart, Liwei Chen, Derek T. A. Lamport, Yuning Chen, and Marcia J. Kieliszewski Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2226–2231. doi: 10.1073/pnas.0711980105.PMCID: PMC2538902 Mechanistic duality of transcription factor function in phytochrome signaling Bassem Al-Sady, Elise A. Kikis, Elena Monte, and Peter H. Quail Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2232–2237. doi: 10.1073/pnas.0711675105.PMCID: PMC2538903 Population Biology Decreases in dengue transmission may act to increase the incidence of dengue hemorrhagic fever Yoshiro Nagao and Katia Koelle Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2238–2243. doi: 10.1073/pnas.0709029105.PMCID: PMC2538904 Ambient temperature predicts sex ratios and male longevity Ralph Catalano, Tim Bruckner, and Kirk R. Smith Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2244–2247. doi: 10.1073/pnas.0710711104.PMCID: PMC2538905 Psychology Perceptual learning depends on perceptual constancy Patrick Garrigan and Philip J. Kellman Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2248–2253. doi: 10.1073/pnas.0711878105.PMCID: PMC2538906 |