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Volume 105(6);  February 12, 2008
This Week in PNAS
In This Issue
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1775–1776. doi: 10.1073/iti0608105.
PMCID: PMC2538836
Commentaries
Biofortified and bioavailable: The gold standard for plant-based diets
Jeeyon Jeong and Mary Lou Guerinot
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1777–1778. doi: 10.1073/pnas.0712330105.
PMCID: PMC2538837
Macromolecular structures without crystals
Robert M. Glaeser
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1779–1780. doi: 10.1073/pnas.0800032105.
PMCID: PMC2538838
Insects take a bigger bite out of plants in a warmer, higher carbon dioxide world
Evan H. DeLucia, Clare L. Casteel, Paul D. Nabity, and Bridget F. O'Neill
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1781–1782. doi: 10.1073/pnas.0712056105.
PMCID: PMC2538839
Perspective
Tipping elements in the Earth's climate system
Timothy M. Lenton, Hermann Held, Elmar Kriegler, Jim W. Hall, Wolfgang Lucht, Stefan Rahmstorf, and Hans Joachim Schellnhuber
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1786–1793. doi: 10.1073/pnas.0705414105.
PMCID: PMC2538841
Profile
Profile of Hans Joachim Schellnhuber
Kaspar Mossman
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1783–1785. doi: 10.1073/pnas.0800554105.
PMCID: PMC2538840
Physical Sciences
Chemistry
Conformational polymorphism in a heteromolecular single crystal leads to concerted movement akin to collective rack-and-pinion gears at the molecular level
Anatoliy N. Sokolov, Dale C. Swenson, and Leonard R. MacGillivray
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1794–1797. doi: 10.1073/pnas.0706117105.
PMCID: PMC2542860
Plasmonic engineering of singlet oxygen generation
Yongxia Zhang, Kadir Aslan, Michael J. R. Previte, and Chris D. Geddes
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1798–1802. doi: 10.1073/pnas.0709501105.
PMCID: PMC2538842
The nature of O2 activation by the ethylene-forming enzyme 1-aminocyclopropane-1-carboxylic acid oxidase
Liviu M. Mirica and Judith P. Klinman
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1814–1819. doi: 10.1073/pnas.0711626105.
PMCID: PMC2538845
Mathematics
Manifold parametrizations by eigenfunctions of the Laplacian and heat kernels
Peter W. Jones, Mauro Maggioni, and Raanan Schul
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1803–1808. doi: 10.1073/pnas.0710175104.
PMCID: PMC2538843
Physics
Controlling energy transfer between multiple dopants within a single nanoparticle
Jeffrey R. DiMaio, Clément Sabatier, Baris Kokuoz, and John Ballato
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1809–1813. doi: 10.1073/pnas.0711638105.
PMCID: PMC2538844
Sustainability Science
Tipping elements in the Earth's climate system
Timothy M. Lenton, Hermann Held, Elmar Kriegler, Jim W. Hall, Wolfgang Lucht, Stefan Rahmstorf, and Hans Joachim Schellnhuber
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1786–1793. doi: 10.1073/pnas.0705414105.
PMCID: PMC2538841
Biological Sciences
Biochemistry
The nature of O2 activation by the ethylene-forming enzyme 1-aminocyclopropane-1-carboxylic acid oxidase
Liviu M. Mirica and Judith P. Klinman
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1814–1819. doi: 10.1073/pnas.0711626105.
PMCID: PMC2538845
Molecular basis for LDL receptor recognition by PCSK9
Hyock Joo Kwon, Thomas A. Lagace, Markey C. McNutt, Jay D. Horton, and Johann Deisenhofer
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1820–1825. doi: 10.1073/pnas.0712064105.
PMCID: PMC2538846
RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli
Brian P. Anton, Lana Saleh, Jack S. Benner, Elisabeth A. Raleigh, Simon Kasif, and Richard J. Roberts
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1826–1831. doi: 10.1073/pnas.0708608105.
PMCID: PMC2538847
Structural identification of the pathway of long-range communication in an allosteric enzyme
Prafull S. Gandhi, Zhiwei Chen, F. Scott Mathews, and Enrico Di Cera
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1832–1837. doi: 10.1073/pnas.0710894105.
PMCID: PMC2538848
Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor
Jieyi Wang, Lora A. Tucker, Jason Stavropoulos, Qian Zhang, Yi-Chun Wang, Gail Bukofzer, Amanda Niquette, Jonathan A. Meulbroek, David M. Barnes, Jianwei Shen, Jennifer Bouska, Cherrie Donawho, George S. Sheppard, and Randy L. Bell
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1838–1843. doi: 10.1073/pnas.0708766105.
PMCID: PMC2538849
Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase
Matthew P. Blakeley, Federico Ruiz, Raul Cachau, Isabelle Hazemann, Flora Meilleur, Andre Mitschler, Stephan Ginell, Pavel Afonine, Oscar N. Ventura, Alexandra Cousido-Siah, Michael Haertlein, Andrzej Joachimiak, Dean Myles, and Alberto Podjarny
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1844–1848. doi: 10.1073/pnas.0711659105.
PMCID: PMC2538850
The kernel energy method of quantum mechanical approximation carried to fourth-order terms
Lulu Huang, Lou Massa, and Jerome Karle
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1849–1854. doi: 10.1073/pnas.0711297105.
PMCID: PMC2538851
Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface
Boriana Marintcheva, Assen Marintchev, Gerhard Wagner, and Charles C. Richardson
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1855–1860. doi: 10.1073/pnas.0711919105.
PMCID: PMC2538852
Structure and mechanism of IFN-γ antagonism by an orthopoxvirus IFN-γ-binding protein
Anthony A. Nuara, Leigh J. Walter, Naomi J. Logsdon, Sung Il Yoon, Brandi C. Jones, Jill M. Schriewer, R. Mark Buller, and Mark R. Walter
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1861–1866. doi: 10.1073/pnas.0705753105.
PMCID: PMC2542861
Biophysics
From the Cover:
Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction
Xing Zhang, Ethan Settembre, Chen Xu, Philip R. Dormitzer, Richard Bellamy, Stephen C. Harrison, and Nikolaus Grigorieff
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1867–1872. doi: 10.1073/pnas.0711623105.
PMCID: PMC2542862
Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2
Jesko Koehnke, Xiangshu Jin, Elaine C. Budreck, Shoshana Posy, Peter Scheiffele, Barry Honig, and Lawrence Shapiro
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1873–1878. doi: 10.1073/pnas.0711701105.
PMCID: PMC2538853
Structural changes in the Mn4Ca cluster and the mechanism of photosynthetic water splitting
Yulia Pushkar, Junko Yano, Kenneth Sauer, Alain Boussac, and Vittal K. Yachandra
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1879–1884. doi: 10.1073/pnas.0707092105.
PMCID: PMC2542863
Atomic force microscopy reveals parallel mechanical unfolding pathways of T4 lysozyme: Evidence for a kinetic partitioning mechanism
Qing Peng and Hongbin Li
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1885–1890. doi: 10.1073/pnas.0706775105.
PMCID: PMC2538854
Use of 13Cα chemical shifts for accurate determination of β-sheet structures in solution
Jorge A. Vila, Yelena A. Arnautova, and Harold A. Scheraga
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1891–1896. doi: 10.1073/pnas.0711022105.
PMCID: PMC2542864
Gene expression dynamics in the macrophage exhibit criticality
Matti Nykter, Nathan D. Price, Maximino Aldana, Stephen A. Ramsey, Stuart A. Kauffman, Leroy E. Hood, Olli Yli-Harja, and Ilya Shmulevich
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1897–1900. doi: 10.1073/pnas.0711525105.
PMCID: PMC2538855
Cell Biology
From the Cover:
Cytoplasmic BKCa channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons
Thomas J. Bell, Kevin Y. Miyashiro, Jai-Yoon Sul, Ronald McCullough, Peter T. Buckley, Jeanine Jochems, David F. Meaney, Phil Haydon, Charles Cantor, Thomas D. Parsons, and James Eberwine
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1901–1906. doi: 10.1073/pnas.0711796105.
PMCID: PMC2538856
Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process
Raymond Pfau, Alexandros Tzatsos, Sotirios C. Kampranis, Oksana B. Serebrennikova, Susan E. Bear, and Philip N. Tsichlis
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1907–1912. doi: 10.1073/pnas.0711865105.
PMCID: PMC2538857
Emergent decision-making in biological signal transduction networks
Tomáš Helikar, John Konvalina, Jack Heidel, and Jim A. Rogers
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1913–1918. doi: 10.1073/pnas.0705088105.
PMCID: PMC2538858
Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing
Zhao-Qiu Wu and Xiaoqi Liu
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1919–1924. doi: 10.1073/pnas.0712063105.
PMCID: PMC2538859
Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway
Adriane Regina Todeschini, Jose Nilson Dos Santos, Kazuko Handa, and Sen-itiroh Hakomori
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1925–1930. doi: 10.1073/pnas.0709619104.
PMCID: PMC2538860
Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network
Olivier C. Pertz, Yingchun Wang, Feng Yang, Wei Wang, Laurie J. Gay, Marina A. Gristenko, Therese R. Clauss, David J. Anderson, Tao Liu, Kenneth J. Auberry, David G. Camp, II, Richard D. Smith, and Richard L. Klemke
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1931–1936. doi: 10.1073/pnas.0706545105.
PMCID: PMC2542865
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis
Nicole Baptiste-Okoh, Anthony M. Barsotti, and Carol Prives
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1937–1942. doi: 10.1073/pnas.0711800105.
PMCID: PMC2538861
Enterococcus faecalis from newborn babies regulate endogenous PPARγ activity and IL-10 levels in colonic epithelial cells
Alexandra Are, Linda Aronsson, Shugui Wang, Gediminas Greicius, Yuan Kun Lee, Jan-Åke Gustafsson, Sven Pettersson, and Velmurugesan Arulampalam
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1943–1948. doi: 10.1073/pnas.0711734105.
PMCID: PMC2538862
Developmental Biology
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
Tatsuya Kobayashi, Jun Lu, Bradley S. Cobb, Stephen J. Rodda, Andrew P. McMahon, Ernestina Schipani, Matthias Merkenschlager, and Henry M. Kronenberg
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1949–1954. doi: 10.1073/pnas.0707900105.
PMCID: PMC2538863
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development
Frances A. High, Min Min Lu, Warren S. Pear, Kathleen M. Loomes, Klaus H. Kaestner, and Jonathan A. Epstein
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1955–1959. doi: 10.1073/pnas.0709663105.
PMCID: PMC2538864
Ecology
From the Cover:
Sharply increased insect herbivory during the Paleocene–Eocene Thermal Maximum
Ellen D. Currano, Peter Wilf, Scott L. Wing, Conrad C. Labandeira, Elizabeth C. Lovelock, and Dana L. Royer
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1960–1964. doi: 10.1073/pnas.0708646105.
PMCID: PMC2538865
Influence of ocean winds on the pelagic ecosystem in upwelling regions
Ryan R. Rykaczewski and David M. Checkley, Jr
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1965–1970. doi: 10.1073/pnas.0711777105.
PMCID: PMC2538866
Increased plant growth from nitrogen addition should conserve phosphorus in terrestrial ecosystems
Michael P. Perring, Lars O. Hedin, Simon A. Levin, Megan McGroddy, and Claire de Mazancourt
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1971–1976. doi: 10.1073/pnas.0711618105.
PMCID: PMC2542866
Coexisting generalist herbivores occupy unique nutritional feeding niches
Spencer T. Behmer and Anthony Joern
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1977–1982. doi: 10.1073/pnas.0711870105.
PMCID: PMC2538867
Evolution
From the Cover:
Discovery of a rare arboreal forest-dwelling flying reptile (Pterosauria, Pterodactyloidea) from China
Xiaolin Wang, Alexander W. A. Kellner, Zhonghe Zhou, and Diogenes de Almeida Campos
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1983–1987. doi: 10.1073/pnas.0707728105.
PMCID: PMC2538868
Paternal effects on offspring fitness in a multimale primate society
M. J. E. Charpentier, R. C. Van Horn, J. Altmann, and S. C. Alberts
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1988–1992. doi: 10.1073/pnas.0711219105.
PMCID: PMC2538869
Extraordinary intraspecific diversity in oyster sperm bindin
G. W. Moy, S. A. Springer, S. L. Adams, W. J. Swanson, and V. D. Vacquier
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1993–1998. doi: 10.1073/pnas.0711862105.
PMCID: PMC2538870
Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei
De-Hua Lai, Hassan Hashimi, Zhao-Rong Lun, Francisco J. Ayala, and Julius Lukeš
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 1999–2004. doi: 10.1073/pnas.0711799105.
PMCID: PMC2538871
Genetics
Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina
Wesley D. Swingley, Min Chen, Patricia C. Cheung, Amber L. Conrad, Liza C. Dejesa, Jicheng Hao, Barbara M. Honchak, Lauren E. Karbach, Ahmet Kurdoglu, Surobhi Lahiri, Stephen D. Mastrian, Hideaki Miyashita, Lawrence Page, Pushpa Ramakrishna, Soichirou Satoh, W. Matthew Sattley, Yuichiro Shimada, Heather L. Taylor, Tatsuya Tomo, Tohru Tsuchiya, Zi T. Wang, Jason Raymond, Mamoru Mimuro, Robert E. Blankenship, and Jeffrey W. Touchman
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2005–2010. doi: 10.1073/pnas.0709772105.
PMCID: PMC2538872
Immunology
Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation
Maria I. Lioudyno, J. Ashot Kozak, Aubin Penna, Olga Safrina, Shenyuan L. Zhang, Debasish Sen, Jack Roos, Kenneth A. Stauderman, and Michael D. Cahalan
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2011–2016. doi: 10.1073/pnas.0706122105.
PMCID: PMC2538873
A role for leptin in sustaining lymphopoiesis and myelopoiesis
Kate Claycombe, Louis E. King, and Pamela J. Fraker
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2017–2021. doi: 10.1073/pnas.0712053105.
PMCID: PMC2538874
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
Ling Xue, Hector Nolla, Akira Suzuki, Tak W. Mak, and Astar Winoto
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2022–2027. doi: 10.1073/pnas.0712059105.
PMCID: PMC2538875
Natural glucocorticoids induce expansion of all developmental stages of murine bone marrow granulocytes without inhibiting function
Mark D. Trottier, Matthew M. Newsted, Louis E. King, and Pamela J. Fraker
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2028–2033. doi: 10.1073/pnas.0712003105.
PMCID: PMC2538876
Epitope-specific TCRβ repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides
Nicole L. La Gruta, Paul G. Thomas, Andrew I. Webb, Michelle A. Dunstone, Tania Cukalac, Peter C. Doherty, Anthony W. Purcell, Jamie Rossjohn, and Stephen J. Turner
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2034–2039. doi: 10.1073/pnas.0711682102.
PMCID: PMC2538877
Structure and specificity of lamprey monoclonal antibodies
Brantley R. Herrin, Matthew N. Alder, Kenneth H. Roux, Christina Sina, Götz R. A. Ehrhardt, Jeremy A. Boydston, Charles L. Turnbough, Jr, and Max D. Cooper
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2040–2045. doi: 10.1073/pnas.0711619105.
PMCID: PMC2542867
Medical Sciences
Aerosol immunization with NYVAC and MVA vectored vaccines is safe, simple, and immunogenic
Max Corbett, Willy M. Bogers, Jonathan L. Heeney, Stefan Gerber, Christian Genin, Arnaud Didierlaurent, Herman Oostermeijer, Rob Dubbes, Gerco Braskamp, Stéphanie Lerondel, Carmen E. Gomez, Mariano Esteban, Ralf Wagner, Ivanella Kondova, Petra Mooij, Sunita Balla-Jhagjhoorsingh, Niels Beenhakker, Gerrit Koopman, Sjoerd van der Burg, Jean-Pierre Kraehenbuhl, and Alain Le Pape
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2046–2051. doi: 10.1073/pnas.0705191105.
PMCID: PMC2538878
Lithium delays progression of amyotrophic lateral sclerosis
Francesco Fornai, Patrizia Longone, Luisa Cafaro, Olga Kastsiuchenka, Michela Ferrucci, Maria Laura Manca, Gloria Lazzeri, Alida Spalloni, Natascia Bellio, Paola Lenzi, Nicola Modugno, Gabriele Siciliano, Ciro Isidoro, Luigi Murri, Stefano Ruggieri, and Antonio Paparelli
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2052–2057. doi: 10.1073/pnas.0708022105.
PMCID: PMC2538879
From the Cover:
Microneedles permit transdermal delivery of a skin-impermeant medication to humans
Daniel P. Wermeling, Stan L. Banks, David A. Hudson, Harvinder S. Gill, Jyoti Gupta, Mark R. Prausnitz, and Audra L. Stinchcomb
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2058–2063. doi: 10.1073/pnas.0710355105.
PMCID: PMC2538880
PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model
Ming Du, Xiaoli Liu, Ellen M. Welch, Samit Hirawat, Stuart W. Peltz, and David M. Bedwell
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2064–2069. doi: 10.1073/pnas.0711795105.
PMCID: PMC2538881
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
Cai-Hong Yun, Kristen E. Mengwasser, Angela V. Toms, Michele S. Woo, Heidi Greulich, Kwok-Kin Wong, Matthew Meyerson, and Michael J. Eck
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2070–2075. doi: 10.1073/pnas.0709662105.
PMCID: PMC2538882
Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia
Su-Jiang Zhang, Li-Yuan Ma, Qiu-Hua Huang, Guo Li, Bai-Wei Gu, Xiao-Dong Gao, Jing-Yi Shi, Yue-Ying Wang, Li Gao, Xun Cai, Rui-Bao Ren, Jiang Zhu, Zhu Chen, and Sai-Juan Chen
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2076–2081. doi: 10.1073/pnas.0711824105.
PMCID: PMC2538883
Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice
Fredrik Johansson, Farah Kramer, Shelley Barnhart, Jenny E. Kanter, Tomas Vaisar, Rachel D. Merrill, Linda Geng, Kazuhiro Oka, Lawrence Chan, Alan Chait, Jay W. Heinecke, and Karin E. Bornfeldt
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2082–2087. doi: 10.1073/pnas.0709958105.
PMCID: PMC2538884
The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development
Paul G. Matteson, Jigar Desai, Ron Korstanje, Gloria Lazar, Tanya E. Borsuk, Jarod Rollins, Sindhuja Kadambi, Jamie Joseph, Taslima Rahman, Jason Wink, Rym Benayed, Beverly Paigen, and James H. Millonig
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2088–2093. doi: 10.1073/pnas.0705657105.
PMCID: PMC2538885
Liver X receptor β (LXRβ): A link between β-sitosterol and amyotrophic lateral sclerosis–Parkinson's dementia
Hyun-Jin Kim, Xiaotang Fan, Chiara Gabbi, Konstantin Yakimchuk, Paolo Parini, Margaret Warner, and Jan-Åke Gustafsson
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2094–2099. doi: 10.1073/pnas.0711599105.
PMCID: PMC2542868
A vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4+ T cell depletion in SHIV-infected macaques
Vincent Vieillard, Roger Le Grand, Jean Dausset, and Patrice Debré
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2100–2104. doi: 10.1073/pnas.0711629105.
PMCID: PMC2542869
A causal role for ERG in neoplastic transformation of prostate epithelium
Olga Klezovitch, Michael Risk, Ilsa Coleman, Jared M. Lucas, Manda Null, Lawrence D. True, Peter S. Nelson, and Valeri Vasioukhin
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2105–2110. doi: 10.1073/pnas.0711711105.
PMCID: PMC2538886
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
Jian-Fu Chen, Elizabeth P. Murchison, Ruhang Tang, Thomas E. Callis, Mariko Tatsuguchi, Zhongliang Deng, Mauricio Rojas, Scott M. Hammond, Michael D. Schneider, Craig H. Selzman, Gerhard Meissner, Cam Patterson, Gregory J. Hannon, and Da-Zhi Wang
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2111–2116. doi: 10.1073/pnas.0710228105.
PMCID: PMC2542870
Microbiology
Symbiotic gut microbes modulate human metabolic phenotypes
Min Li, Baohong Wang, Menghui Zhang, Mattias Rantalainen, Shengyue Wang, Haokui Zhou, Yan Zhang, Jian Shen, Xiaoyan Pang, Meiling Zhang, Hua Wei, Yu Chen, Haifeng Lu, Jian Zuo, Mingming Su, Yunping Qiu, Wei Jia, Chaoni Xiao, Leon M. Smith, Shengli Yang, Elaine Holmes, Huiru Tang, Guoping Zhao, Jeremy K. Nicholson, Lanjuan Li, and Liping Zhao
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2117–2122. doi: 10.1073/pnas.0712038105.
PMCID: PMC2538887
Superinfection as a driver of genomic diversification in antigenically variant pathogens
James E. Futse, Kelly A. Brayton, Michael J. Dark, Donald P. Knowles, Jr., and Guy H. Palmer
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2123–2127. doi: 10.1073/pnas.0710333105.
PMCID: PMC2538888
The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features
Henning Seedorf, W. Florian Fricke, Birgit Veith, Holger Brüggemann, Heiko Liesegang, Axel Strittmatter, Marcus Miethke, Wolfgang Buckel, Julia Hinderberger, Fuli Li, Christoph Hagemeier, Rudolf K. Thauer, and Gerhard Gottschalk
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2128–2133. doi: 10.1073/pnas.0711093105.
PMCID: PMC2542871
A moderately thermophilic ammonia-oxidizing crenarchaeote from a hot spring
Roland Hatzenpichler, Elena V. Lebedeva, Eva Spieck, Kilian Stoecker, Andreas Richter, Holger Daims, and Michael Wagner
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2134–2139. doi: 10.1073/pnas.0708857105.
PMCID: PMC2538889
Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes
Erika Assarsson, Jason A. Greenbaum, Magnus Sundström, Lana Schaffer, Jennifer A. Hammond, Valerie Pasquetto, Carla Oseroff, R. Curtis Hendrickson, Elliot J. Lefkowitz, David C. Tscharke, John Sidney, Howard M. Grey, Steven R. Head, Bjoern Peters, and Alessandro Sette
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2140–2145. doi: 10.1073/pnas.0711573105.
PMCID: PMC2542872
Translation initiation factor a/eIF2(-γ) counteracts 5′ to 3′ mRNA decay in the archaeon Sulfolobus solfataricus
David Hasenöhrl, Tania Lombo, Vladimir Kaberdin, Paola Londei, and Udo Bläsi
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2146–2150. doi: 10.1073/pnas.0708894105.
PMCID: PMC2538890
Centromere anatomy in the multidrug-resistant pathogen Enterococcus faecium
Andrew Derome, Christian Hoischen, Malte Bussiek, Ruth Grady, Malgorzata Adamczyk, Barbara Kędzierska, Stephan Diekmann, Daniela Barillà, and Finbarr Hayes
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2151–2156. doi: 10.1073/pnas.0704681105.
PMCID: PMC2538891
Neuroscience
The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels
Curtis F. Barrett and Richard W. Tsien
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2157–2162. doi: 10.1073/pnas.0710501105.
PMCID: PMC2538892
Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in l-DOPA treatment of an animal model of Parkinsonism
Xiaoqun Zhang, Per E. Andren, Paul Greengard, and Per Svenningsson
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2163–2168. doi: 10.1073/pnas.0711839105.
PMCID: PMC2538893
Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons
Hongmei Li, Yingbei Chen, Adrienne F. Jones, Richard H. Sanger, Leon P. Collis, Richard Flannery, Ewan C. McNay, Tingxi Yu, Robert Schwarzenbacher, Blaise Bossy, Ella Bossy-Wetzel, Michael V. L. Bennett, Marc Pypaert, John A. Hickman, Peter J. S. Smith, J. Marie Hardwick, and Elizabeth A. Jonas
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2169–2174. doi: 10.1073/pnas.0711647105.
PMCID: PMC2542873
Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons
Mitsuko Hayashi, Andrea Raimondi, Eileen O'Toole, Summer Paradise, Chiara Collesi, Ottavio Cremona, Shawn M. Ferguson, and Pietro De Camilli
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2175–2180. doi: 10.1073/pnas.0712171105.
PMCID: PMC2538894
Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation
Saul L. Miller, Kim Celone, Kristina DePeau, Eli Diamond, Bradford C. Dickerson, Dorene Rentz, Maija Pihlajamäki, and Reisa A. Sperling
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2181–2186. doi: 10.1073/pnas.0706818105.
PMCID: PMC2538895
Robust but delayed thalamocortical activation of dendritic-targeting inhibitory interneurons
Zhenjun Tan, Hang Hu, Z. Josh Huang, and Ariel Agmon
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2187–2192. doi: 10.1073/pnas.0710628105.
PMCID: PMC2538896
Pharmacology
Commensal microbiota is fundamental for the development of inflammatory pain
F. A. Amaral, D. Sachs, V. V. Costa, C. T. Fagundes, D. Cisalpino, T. M. Cunha, S. H. Ferreira, F. Q. Cunha, T. A. Silva, J. R. Nicoli, L. Q. Vieira, D. G. Souza, and M. M. Teixeira
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2193–2197. doi: 10.1073/pnas.0711891105.
PMCID: PMC2538897
Physiology
Remodeling of ryanodine receptor complex causes “leaky” channels: A molecular mechanism for decreased exercise capacity
Andrew M. Bellinger, Steven Reiken, Miroslav Dura, Peter W. Murphy, Shi-Xian Deng, Donald W. Landry, David Nieman, Stephan E. Lehnart, Mahendranauth Samaru, Alain LaCampagne, and Andrew R. Marks
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2198–2202. doi: 10.1073/pnas.0711074105.
PMCID: PMC2538898
TASK channel deletion in mice causes primary hyperaldosteronism
Lucinda A. Davies, Changlong Hu, Nick A. Guagliardo, Neil Sen, Xiangdong Chen, Edmund M. Talley, Robert M. Carey, Douglas A. Bayliss, and Paula Q. Barrett
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2203–2208. doi: 10.1073/pnas.0712000105.
PMCID: PMC2538899
When pliers become fingers in the monkey motor system
M. A. Umiltà, L. Escola, I. Intskirveli, F. Grammont, M. Rochat, F. Caruana, A. Jezzini, V. Gallese, and G. Rizzolatti
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2209–2213. doi: 10.1073/pnas.0705985105.
PMCID: PMC2538900
Plant Biology
Resetting of FLOWERING LOCUS C expression after epigenetic repression by vernalization
Candice C. Sheldon, Melissa J. Hills, Clare Lister, Caroline Dean, Elizabeth S. Dennis, and W. James Peacock
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2214–2219. doi: 10.1073/pnas.0711453105.
PMCID: PMC2542874
Signaling of cell fate determination by the TPD1 small protein and EMS1 receptor kinase
Gengxiang Jia, Xiaodong Liu, Heather A. Owen, and Dazhong Zhao
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2220–2225. doi: 10.1073/pnas.0708795105.
PMCID: PMC2538901
Self-assembly of the plant cell wall requires an extensin scaffold
Maura C. Cannon, Kimberly Terneus, Qi Hall, Li Tan, Yumei Wang, Benjamin L. Wegenhart, Liwei Chen, Derek T. A. Lamport, Yuning Chen, and Marcia J. Kieliszewski
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2226–2231. doi: 10.1073/pnas.0711980105.
PMCID: PMC2538902
Mechanistic duality of transcription factor function in phytochrome signaling
Bassem Al-Sady, Elise A. Kikis, Elena Monte, and Peter H. Quail
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2232–2237. doi: 10.1073/pnas.0711675105.
PMCID: PMC2538903
Population Biology
Decreases in dengue transmission may act to increase the incidence of dengue hemorrhagic fever
Yoshiro Nagao and Katia Koelle
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2238–2243. doi: 10.1073/pnas.0709029105.
PMCID: PMC2538904
Ambient temperature predicts sex ratios and male longevity
Ralph Catalano, Tim Bruckner, and Kirk R. Smith
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2244–2247. doi: 10.1073/pnas.0710711104.
PMCID: PMC2538905
Psychology
Perceptual learning depends on perceptual constancy
Patrick Garrigan and Philip J. Kellman
Proc Natl Acad Sci U S A. 2008 February 12; 105(6): 2248–2253. doi: 10.1073/pnas.0711878105.
PMCID: PMC2538906
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