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Volume 36(13);  August 2008
Chemistry and Synthetic Biology
Systematic analysis of enzymatic DNA polymerization using oligo-DNA templates and triphosphate analogs involving 2′,4′-bridged nucleosides
Masayasu Kuwahara, Satoshi Obika, Jun-ichi Nagashima, Yuki Ohta, Yoshiyuki Suto, Hiroaki Ozaki, Hiroaki Sawai, and Takeshi Imanishi
Nucleic Acids Res. 2008 August; 36(13): 4257–4265. Published online 2008 August. doi: 10.1093/nar/gkn404.
PMCID: PMC2490744
Editorial
Editorial
Nucleic Acids Res. 2008 August; 36(13): 4221. Published online 2008 August. doi: 10.1093/nar/gkn478.
PMCID: PMC2490764
Gene Regulation, Chromatin and Epigenetics
Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk
Carmen Spatuzza, Marco Schiavone, Emanuela Di Salle, Elzbieta Janda, Marco Sardiello, Giuseppe Fiume, Olga Fierro, Marco Simonetta, Notis Argiriou, Raffaella Faraonio, Rosanna Capparelli, Ileana Quinto, and Giuseppe Scala
Nucleic Acids Res. 2008 August; 36(13): 4402–4416. Published online 2008 August. doi: 10.1093/nar/gkn413.
PMCID: PMC2490745
TAp73β and DNp73β activate the expression of the pro-survival caspase-2S
Wen Hong Toh, Emmanuelle Logette, Laurent Corcos, and Kanaga Sabapathy
Nucleic Acids Res. 2008 August; 36(13): 4498–4509. Published online 2008 August. doi: 10.1093/nar/gkn414.
PMCID: PMC2490756
Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
Sutapa Ray, Chang Lee, Tieying Hou, Istvan Boldogh, and Allan R. Brasier
Nucleic Acids Res. 2008 August; 36(13): 4510–4520. Published online 2008 August. doi: 10.1093/nar/gkn419.
PMCID: PMC2490754
Molecular Biology
p73α isoforms drive opposite transcriptional and post-transcriptional regulation of MYCN expression in neuroblastoma cells
Emilie Horvilleur, Matthieu Bauer, David Goldschneider, Xénia Mergui, Alix de La Motte, Jean Bénard, Sétha Douc-Rasy, and David Cappellen
Nucleic Acids Res. 2008 August; 36(13): 4222–4232. Published online 2008 August. doi: 10.1093/nar/gkn394.
PMCID: PMC2490757
Minigene-like inhibition of protein synthesis mediated by hungry codons near the start codon
Eva Jacinto-Loeza, Serafín Vivanco-Domínguez, Gabriel Guarneros, and Javier Hernández-Sánchez
Nucleic Acids Res. 2008 August; 36(13): 4233–4241. Published online 2008 August. doi: 10.1093/nar/gkn395.
PMCID: PMC2490762
Filament formation and robust strand exchange activities of the rice DMC1A and DMC1B proteins
Isao Sakane, Chiaki Kamataki, Yoshimasa Takizawa, Marina Nakashima, Seiichi Toki, Hiroaki Ichikawa, Shukuko Ikawa, Takehiko Shibata, and Hitoshi Kurumizaka
Nucleic Acids Res. 2008 August; 36(13): 4266–4276. Published online 2008 August. doi: 10.1093/nar/gkn405.
PMCID: PMC2490746
The Zur of Xanthomonas campestris functions as a repressor and an activator of putative zinc homeostasis genes via recognizing two distinct sequences within its target promoters
Dong-Liang Huang, Dong-Jie Tang, Qing Liao, Heng-Cong Li, Qi Chen, Yong-Qiang He, Jia-Xun Feng, Bo-Le Jiang, Guang-Tao Lu, Baoshan Chen, and Ji-Liang Tang
Nucleic Acids Res. 2008 August; 36(13): 4295–4309. Published online 2008 August. doi: 10.1093/nar/gkn328.
PMCID: PMC2490734
YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase
Sugopa Sengupta and Valakunja Nagaraja
Nucleic Acids Res. 2008 August; 36(13): 4310–4316. Published online 2008 August. doi: 10.1093/nar/gkn355.
PMCID: PMC2490753
The Ty1 integrase protein can exploit the classical nuclear protein import machinery for entry into the nucleus
Laura M. McLane, Kanika F. Pulliam, Scott E. Devine, and Anita H. Corbett
Nucleic Acids Res. 2008 August; 36(13): 4317–4326. Published online 2008 August. doi: 10.1093/nar/gkn383.
PMCID: PMC2490736
A new APE1/Ref-1-dependent pathway leading to reduction of NF-κB and AP-1, and activation of their DNA-binding activity
Kozue Ando, Satoshi Hirao, Yasuaki Kabe, Yuji Ogura, Iwao Sato, Yuki Yamaguchi, Tadashi Wada, and Hiroshi Handa
Nucleic Acids Res. 2008 August; 36(13): 4327–4336. Published online 2008 August. doi: 10.1093/nar/gkn416.
PMCID: PMC2490748
Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression
Liang-Yi Hung, Joseph T. Tseng, Yi-Chao Lee, Weiya Xia, Ying-Nai Wang, Min-Li Wu, Yu-Hsuan Chuang, Chein-Hsien Lai, and Wen-Chang Chang
Nucleic Acids Res. 2008 August; 36(13): 4337–4351. Published online 2008 August. doi: 10.1093/nar/gkn417.
PMCID: PMC2490761
Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells
Takehiko Shiraishi, Ramin Hamzavi, and Peter E. Nielsen
Nucleic Acids Res. 2008 August; 36(13): 4424–4432. Published online 2008 August. doi: 10.1093/nar/gkn401.
PMCID: PMC2490735
The structure of the 5′-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation
Luchezar Karagyozov, Rinesh Godfrey, Sylvia-Annette Böhmer, Astrid Petermann, Sebastian Hölters, Arne Östman, and Frank-D. Böhmer
Nucleic Acids Res. 2008 August; 36(13): 4443–4453. Published online 2008 August. doi: 10.1093/nar/gkn391.
PMCID: PMC2490741
PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility
Camille Godon, Fabrice P. Cordelières, Denis Biard, Nicole Giocanti, Frédérique Mégnin-Chanet, Janet Hall, and Vincent Favaudon
Nucleic Acids Res. 2008 August; 36(13): 4454–4464. Published online 2008 August. doi: 10.1093/nar/gkn403.
PMCID: PMC2490739
RNA
Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites
Nan Li, Alex S. Flynt, H. Rosemary Kim, Lilianna Solnica-Krezel, and James G. Patton
Nucleic Acids Res. 2008 August; 36(13): 4277–4285. Published online 2008 August. doi: 10.1093/nar/gkn388.
PMCID: PMC2490740
Destabilization of the TAR hairpin affects the structure and function of the HIV-1 leader RNA
Martine M. Vrolijk, Marcel Ooms, Alex Harwig, Atze T. Das, and Ben Berkhout
Nucleic Acids Res. 2008 August; 36(13): 4352–4363. Published online 2008 August. doi: 10.1093/nar/gkn364.
PMCID: PMC2490758
Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes
Åsa Segerstolpe, Pär Lundkvist, Yvonne N. Osheim, Ann L. Beyer, and Lars Wieslander
Nucleic Acids Res. 2008 August; 36(13): 4364–4380. Published online 2008 August. doi: 10.1093/nar/gkn384.
PMCID: PMC2490760
p100 increases AT1R expression through interaction with AT1R 3′-UTR
Kirsi Paukku, Nisse Kalkkinen, Olli Silvennoinen, Kimmo K. Kontula, and Jukka Y. A. Lehtonen
Nucleic Acids Res. 2008 August; 36(13): 4474–4487. Published online 2008 August. doi: 10.1093/nar/gkn411.
PMCID: PMC2490763
Structural Biology
A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR
Marcus Resch, Harald Striegl, Eva Maria Henssler, Madhumati Sevvana, Claudia Egerer-Sieber, Emile Schiltz, Wolfgang Hillen, and Yves A. Muller
Nucleic Acids Res. 2008 August; 36(13): 4390–4401. Published online 2008 August. doi: 10.1093/nar/gkn400.
PMCID: PMC2490752
Effect of loop length variation on quadruplex-Watson Crick duplex competition
Niti Kumar, Bankanidhi Sahoo, K. A. S. Varun, Sudipta Maiti, and Souvik Maiti
Nucleic Acids Res. 2008 August; 36(13): 4433–4442. Published online 2008 August. doi: 10.1093/nar/gkn402.
PMCID: PMC2490738
Survey and Summary
See me, feel me: methods to concurrently visualize and manipulate single DNA molecules and associated proteins
Joost van Mameren, Erwin J. G. Peterman, and Gijs J. L. Wuite
Nucleic Acids Res. 2008 August; 36(13): 4381–4389. Published online 2008 August. doi: 10.1093/nar/gkn412.
PMCID: PMC2490750
Genomics
Effect of polymorphisms within probe–target sequences on olignonucleotide microarray experiments
David Benovoy, Tony Kwan, and Jacek Majewski
Nucleic Acids Res. 2008 August; 36(13): 4417–4423. Published online 2008 August. doi: 10.1093/nar/gkn409.
PMCID: PMC2490733
Methods Online
Expanded molecular diversity generation during directed evolution by trinucleotide exchange (TriNEx)
Amy J. Baldwin, Kathy Busse, Alan M. Simm, and D. Dafydd Jones
Nucleic Acids Res. 2008 August; 36(13): e77. Published online 2008 August. doi: 10.1093/nar/gkn358.
PMCID: PMC2490759
Linking the functions of unrelated proteins using a novel directed evolution domain insertion method
Wayne R. Edwards, Kathy Busse, Rudolf K. Allemann, and D. Dafydd Jones
Nucleic Acids Res. 2008 August; 36(13): e78. Published online 2008 August. doi: 10.1093/nar/gkn363.
PMCID: PMC2490766
Primase-based whole genome amplification
Ying Li, Hyun-Jin Kim, Chunyang Zheng, Wing Huen A. Chow, Jeonghwa Lim, Brendan Keenan, Xiaojing Pan, Bertrand Lemieux, and Huimin Kong
Nucleic Acids Res. 2008 August; 36(13): e79. Published online 2008 August. doi: 10.1093/nar/gkn377.
PMCID: PMC2490742
Impact of whole genome amplification on analysis of copy number variants
T. J. Pugh, A. D. Delaney, N. Farnoud, S. Flibotte, M. Griffith, H. I. Li, H. Qian, P. Farinha, R. D. Gascoyne, and M. A. Marra
Nucleic Acids Res. 2008 August; 36(13): e80. Published online 2008 August. doi: 10.1093/nar/gkn378.
PMCID: PMC2490749
Quick identification of Type I restriction enzyme isoschizomers using newly developed pTypeI and reference plasmids
Junichi Ryu and Edward Rowsell
Nucleic Acids Res. 2008 August; 36(13): e81. Published online 2008 August. doi: 10.1093/nar/gkn056.
PMCID: PMC2490747
Long-range, high-throughput haplotype determination via haplotype-fusion PCR and ligation haplotyping
Daniel J. Turner, Chris Tyler-Smith, and Matthew E. Hurles
Nucleic Acids Res. 2008 August; 36(13): e82. Published online 2008 August. doi: 10.1093/nar/gkn373.
PMCID: PMC2490767
Conditional gene vectors regulated in cis
Dagmar Pich, Sibille Humme, Mark-Peter Spindler, Aloys Schepers, and Wolfgang Hammerschmidt
Nucleic Acids Res. 2008 August; 36(13): e83. Published online 2008 August. doi: 10.1093/nar/gkn273.
PMCID: PMC2490737
Computational Biology
Global investigation of protein–protein interactions in yeast Saccharomyces cerevisiae using re-occurring short polypeptide sequences
S. Pitre, C. North, M. Alamgir, M. Jessulat, A. Chan, X. Luo, J. R. Green, M. Dumontier, F. Dehne, and A. Golshani
Nucleic Acids Res. 2008 August; 36(13): 4286–4294. Published online 2008 August. doi: 10.1093/nar/gkn390.
PMCID: PMC2490765
MOPAT: a graph-based method to predict recurrent cis-regulatory modules from known motifs
Jianfei Hu, Haiyan Hu, and Xiaoman Li
Nucleic Acids Res. 2008 August; 36(13): 4488–4497. Published online 2008 August. doi: 10.1093/nar/gkn407.
PMCID: PMC2490743
Nucleic Acid Enzymes
Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase
Gregory Sowd, Ming Lei, and Patricia L. Opresko
Nucleic Acids Res. 2008 August; 36(13): 4242–4256. Published online 2008 August. doi: 10.1093/nar/gkn385.
PMCID: PMC2490755
TbMP42 is a structure-sensitive ribonuclease that likely follows a metal ion catalysis mechanism
Moritz Niemann, Michael Brecht, Elke Schlüter, Kerstin Weitzel, Martin Zacharias, and H. Ulrich Göringer
Nucleic Acids Res. 2008 August; 36(13): 4465–4473. Published online 2008 August. doi: 10.1093/nar/gkn410.
PMCID: PMC2490751
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